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301.
微量热法研究β-环糊精与3-烷氧基-2-羟丙基三甲基溴化铵的相互作用 总被引:2,自引:2,他引:2
在 2 98 .15K下用微量热法研究了 β 环糊精与 3 烷氧基 2 羟丙基三甲基溴化铵在水溶液中的包结作用 .实验表明 ,随着疏水链CnH2n + 1O中碳原子数目n的增加 (n =8,12 ,14 ) ,主 -客体包合物的化学计量比由 1∶1为主变为 2∶1为主 .各包合物都比较稳定 ,对应于n =8,12 ,14所得实验稳定常数分别为 :β1=1.0 8× 10 -3 dm3 ·mol-1,β1=2 8.66× 10 3 dm3 ·mol-1,β2 =14 1.9× 10 3 dm6·mol-2 .形成包合物的过程都是焓、熵共同驱动的过程 .包合物标准形成焓 (ΔH )和标准形成熵(ΔS )随着CnH2n+ 1O中碳原子数目n的增加而减小 .从主、客体的微观结构及包合物形成前后表面活性剂离子周围溶剂分子排列结构的变化出发对实验结果进行了讨论 相似文献
302.
主体环糊精聚合物(β-CDE)与客体疏水改性丙烯酰胺共聚物P(AM/POEA)构成超分子结构的高分子识别体系. 这种客体聚合物是含有少量疏水体(xPOEA<0.01)的水溶性聚合物, NMR测定结果表明β-CDE和P(AM/POEA)的主客体相互作用是通过环糊精空腔和疏水体POEA形成包结络合物进行的. 在P(AM/POEA)聚合物水溶液中加入β-CDE, 由于主客体聚合物相互作用出现粘度的大幅上升, 增粘的幅度可通过改变聚合物浓度和疏水体含量来调节, 同时对盐浓度和温度的影响也进行了研究. 通过透射电镜直观观察的结果表明, 此类缔合聚合物体系的主客体相互作用生成实心球状多分子聚集体. 相似文献
303.
Stanislaw Miertus Vladimir Frecer Emo Chiellini Federica Chiellini Roberto Solaro Jacopo Tomasi 《Journal of inclusion phenomena and macrocyclic chemistry》1998,32(1):23-46
Using a simple molecular mechanics approach interaction energy profiles of simple probes (C, CH4, C6H6, H2O, NH4
+, and HCOO-) passing through the center of the -CD ring cavity along the main molecular symmetry axis were first evaluated. Molecular Electrostatic Potential (MEP) values along the same path were also evaluated. The effect of the flexibility of the host -CD molecule together with solute-solvent (H2O) interactions have been represented by averaging structures of MD calculations for -CD alone and -CD surrounded by 133 H2O molecules. The effect of various substitutions of -CD has also been evaluated. Small symmetric hydrophobic probes (such as C, CH4, C6H6) are predicted to form stable inclusion complexes with non-substituted and substituted -CDs, the probe position typically being near the cavity center. The stability of the inclusion complexes will increase with increasing size and aliphatic character of the probe. Small polar and charged probes (such as H2O, NH4
+, HCOO-) are predicted to prefer the interaction with the solvent (water) in the bulk phase rather than the formation of inclusion complexes with non-substituted and substituted -CDs. Guest–host interactions in the stable inclusion complexes with hydrophobic probes are almost entirely dominated by dispersion interactions. The MEP reaches magnitudes close to zero in the center of the non-substituted -CD ring cavity and in most of the studied substituted -CDs and shows maximum positive or negative values outside of the cavity, near the ring faces. Substitution of -CD by neutral substituents leads to enhanced binding of hydrophobic probes and significant changes in the MEP profile along the -CD symmetry axis. 相似文献
304.
305.
Cristina Negro Paula Escamilla Rosaria Bruno Dr. Jesus Ferrando-Soria Dr. Donatella Armentano Dr. Emilio Pardo 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(24):e202200034
The combination of high crystallinity and rich host-guest chemistry in metal-organic frameworks (MOFs), have situated them in an advantageous position, with respect to traditional porous materials, to gain insight on specific weak noncovalent supramolecular interactions. In particular, sulfur σ-hole interactions are known to play a key role in the biological activity of living beings as well as on relevant molecular recognitions processes. However, so far, they have been barely explored. Here, we describe both how the combination of the intrinsic features of MOFs, especially the possibility of using single-crystal X-ray crystallography (SCXRD), can be an extremely valuable tool to gain insight on sulfur σ-hole interactions, and how their rational exploitation can be enormously useful in the efficient removal of harmful organic molecules from aquatic ecosystems. Thus, we have used a MOF, prepared from the amino acid L-methionine and possessing channels decorated with −CH2CH2SCH3 thioalkyl chains, to remove a family of organic dyes at very low concentrations (10 ppm) from water. This MOF is able to efficiently capture the four dyes in a very fast manner, reaching within five minutes nearly the maximum removal. Remarkably, the crystal structure of the different organic dyes within MOFs channels could be determined by SCXRD. This has enabled us to directly visualize the important role sulfur σ-hole interactions play on the removal of organic dyes from aqueous solutions, representing one of the first studies on the rational exploitation of σ-hole interactions for water remediation. 相似文献
306.
Xander Schaapkens Roy N. van Sluis Eduard O. Bobylev Prof. Dr. Joost N. H. Reek Dr. Tiddo J. Mooibroek 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(55):13719-13724
The sialic acid N-acetylneuraminic acid (Neu5Ac) and its derivatives are involved in many biological processes including cell-cell recognition and infection by influenza. Molecules that can recognize Neu5Ac might thus be exploited to intervene in or monitor such events. A key obstacle in this development is the sparse availability of easily prepared molecules that bind to this carbohydrate in its natural solvent; water. Here, we report that the carbohydrate binding pocket of an organic soluble [Pd2L4]4+ cage could be equipped with guanidinium-terminating dendrons to give the water soluble [Pd2L4][NO3]16 cage 7 . It was shown by means of NMR spectroscopy that 7 binds selectively to anionic monosaccharides and strongest to Neu5Ac with Ka=24 M−1. The cage had low to no affinity for the thirteen neutral saccharides studied. Aided by molecular modeling, the selectivity for anionic carbohydrates such as Neu5Ac could be rationalized by the presence of charge assisted hydrogen bonds and/or the presence of a salt bridge with a guanidinium solubilizing arm of 7 . Establishing that a simple coordination cage such as 7 can already selectively bind to Neu5Ac in water paves the way to improve the stability, affinity and/or selectivity properties of M2L4 cages for carbohydrates and other small molecules. 相似文献
307.
冠醚的发现开创了一门新的学科--超分子化学。本院开设的“综合化学实验”首次引入这类物质的合成和表征,通过醚化反应合成了典型的冠类化合物--苯并21冠7(B21C7),然后与二级铵盐通过主客体相互作用形成配合物(简称准轮烷);最后采用核磁共振滴定法研究其络合能力。通过本实验的实施,不仅提升了学生的基本实验操作能力,巩固了专业知识的理解,训练了学生的大型仪器测试分析能力;而且拓宽了学生的科研视野,提高了他们的探索创新意识。建议纳入本科高年级和研究生低年级的“综合化学实验”课程。 相似文献
308.
Cucurbit[n]urils, the pumpkin shaped macrocyclic host molecules possessing a hydrophobic cavity and two identical carbonyl portals, have drawn a lot of attention in recent years due to their high-affinity yet dynamic molecular recognition properties in water. The reversible and stimuli-responsive nature of their host-guest complexes imparts “smart” features leading to materials with intriguing optical, mechanical and morphological properties. In this review, we focus on the design of cucurbituril based luminescent materials in aqueous media as well in solid or film state. The design principles of fluorescent complexes, small assemblies as well as supramolecular polymers along with their stimuli-responsive properties and applications in diverse areas such as optoelectronic devices, light harvesting, anti-counterfeiting and information technology, cell imaging, etc are highlighted with selected examples from recent literature. We also discuss examples of room temperature phosphorescent materials derived from purely organic luminogens in the presence of cucurbiturils. 相似文献
309.
Clve D. Mboyi Ons Amamou Paul Fleurat-Lessard Julien Roger Hlne Cattey Charles H. Devillers Michel Meyer Taoufik Boubaker Jean-Cyrille Hierso 《Molecules (Basel, Switzerland)》2021,26(9)
The carbon-carbon cross-coupling of phenyl s-tetrazine (Tz) units at their ortho-phenyl positions allows the formation of constrained bis(tetrazines) with original tweezer structures. In these compounds, the face-to-face positioning of the central tetrazine cores is reinforced by π-stacking of the electron-poor nitrogen-containing heteroaromatic moieties. The resulting tetra-aromatic structure can be used as a weak coordinating ligand with cationic silver. This coordination generates a set of bis(tetrazine)-silver(I) coordination complexes tolerating a large variety of counter anions of various geometries, namely, PF6−, BF4−, SbF6−, ClO4−, NTf2−, and OTf−. These compounds were characterized in the solid state by single-crystal X-ray diffraction (XRD) and diffuse reflectance spectroscopy, and in solution by 1H-NMR, mass spectrometry, electroanalysis, and UV-visible absorption spectrophotometry. The X-ray crystal structure of complexes {[Ag(3)][PF6]}∞ (4) and {[Ag(3)][SbF6]}∞ (6), where 3 is 3,3′-[(1,1′-biphenyl)-2,2′-diyl]-6,6′-bis(phenyl)-1,2,4,5-tetrazine, revealed the formation of 1D polymeric chains, characterized by an evolution to a large opening of the original tweezer and a coordination of silver(I) via two chelating nitrogen atom and some C=C π-interactions. Electrochemical and UV spectroscopic properties of the original tweezer and of the corresponding silver complexes are reported and compared. 1H-NMR titrations with AgNTf2 allowed the determination of the stoichiometry and apparent stability of two solution species, namely [Ag(3)]+ and [Ag(3)2]2+, that formed in CDCl3/CD3OD 2:1 v/v mixtures. 相似文献
310.
A water-soluble cyclophane dimer having two disulfide groups as a reduction-responsive cleavable bond as well as several acidic and basic functional groups as a pH-responsive ionizable group 1 was successfully synthesized. It was found that 1 showed pH-dependent guest-binding behavior. That is, 1 strongly bound an anionic guest, 6-p-toluidinonaphthalene-2-sulfonate (TNS) with binding constant (K/M−1) for 1:1 host-guest complexes of 9.6 × 104 M−1 at pH 3.8, which was larger than those at pH 7.4 and 10.7 (6.0 × 104 and 2.4 × 104 M−1, respectively), indicating a favorable electrostatic interaction between anionic guest and net cationic 1. What is more, release of the entrapped guest molecules by 1 was easily controlled by pH stimulus. Large favorable enthalpies (ΔH) for formation of host-guest complexes were obtained under the pH conditions employed, suggesting that electrostatic interaction between anionic TNS and 1 was the most important driving force for host-guest complexation. Such contributions of ΔH for formation of host-guest complexes decreased along with increased pH values from acidic to basic solutions. Upon addition of dithiothreitol (DTT) as a reducing reagent to an aqueous PBS buffer (pH 7.4) containing 1 and TNS, the fluorescence intensity originating from the bound guest molecules decreased gradually. A treatment of 1 with DTT gave 2, having less guest-binding affinity by the cleavage of disulfide bonds of 1. Consequently, almost all entrapped guest molecules by 1 were released from the host. Moreover, such reduction-responsive cleavage of 1 and release of bound guest molecules was performed more rapidly in aqueous buffer at pH 10.7. 相似文献