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A series of 4-aryl-6-aryloxymethylmorpholin-3-one derivatives were synthesized very efficiently from readily available starting compounds in two steps. Ring opening reactions of epoxides with aniline compounds on alumina gave corresponding β-aminoalcohols (3). The resulting β-aminoalcohols were reacted with 2-chloroacetyl chloride to yield the desired 4-aryl-6-aryloxymethylmorpholin-3-one derivatives (5). All compounds 5 were assayed for inhibitory activity against A549 lung cancer cell growth, and the inhibitory effect of the novel morpholin-3-ones on cell viability was dose-dependent. 相似文献
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通过硝酮与烯烃化合物的1, 32偶极环加成反应合成了许多天然产物, 如生物碱、B2内酰胺、生物素、氨基糖等。该综述介绍了这一国际前沿研究领域的进展。 相似文献