Synthesis and characterization of insulin-5-Fu conjugate,enabling insulin as multi-drug carrier via dendritic approach

To enable insulin as multi-drug carrier, we designed and synthesized dendritic linker molecule bearing three 5-Fluorouracil residues at the branch ends. The new conjugate showed excellent water solubility. The stabilities under different conditions were investigated. The results showed that the conjugate was a potential prodrug to release free 5-Fu.     

双腔双波长交叉锁模钛宝石飞秒激光器的研究

本文建立了一台双光束泵浦的双腔双波长交叉锁模Ti:Sapphire激光器,实现了中心波长为755nm和845nm的双波长同步锁模输出,得到了脉宽分别为28fs和34fs的锁模脉冲.     

温度对CP43内色素分子间能量传递的影响

对CP43进行不同温度处理5分钟，采用锁模Ar^ 激光器输出的514.5nm的皮秒光脉冲作为激励光，通过探测CP43的荧光光谱特性，来研究色素分子间的能量传递。分析表明，20℃处理后，CP43内Chla671向Chla679和Chla682同时传递能量，并且Chla679也向Chla682传递能量，Chla682获得的能量是Chla679获得能量的1.5倍。42℃处理后，Chla671向Chla679和Chla679向Chla682的能量传递加速，最终能量几乎全部由Chla682接收。48℃处理后，Chla679向Chla682的能量传递减慢，甚至断裂，Chla671将能量分别传递给Chla679和Chla682，但是Chla682接收到的能量略多于Chla679色素分子。60℃处理后，造成了Chla671向Chla679能量传递截止，Chla671向Chla682的能量传递发生了部分截止，因此Chla671的能量部分传递Chla682。不同温度处理后的荧光强度变化表明，Chla671接收到的能量受到蛋白空间构象的影响，在48℃处理后，接收到的能量是最多的，60℃处理后，接收到的能量最少。     

Capillary electrophoresis with direct chemiluminescence detection for the analysis of catecholamines in human urine

A rapid and sensitive method for the analysis of three catecholamines by capillary electrophoresis(CE)with directchemiluminescence(CL)detection is described.The detection limits(S/N=3)were 1.3*10-8g/mL for isoprenaline,1.0*10-8g/mL for epinephrine and 2.8*10-8g/mL for dopamine.The proposed method was successfully applied to theanalysis of catecholamines in urine samples of cigarette smokers and nonsmokers.The results showed that there is a close relationbetween the release of dopamine in human body fluids and cigarette smoking/nonsmoking.     

Structural Study of Inclusion Complex of Andrographolide with β-Cyclodextrin Prepared under Microwave Irradiation

Andrographolide (Andro) (Figure 1) is a diterpene lactone isolated from Andrographis paniculate Nees1. It has showed several biological activities including analgesic, antipyretic and anti-inflammatory effects2. However, its poor water solubility and unstability towards oxygen restrained its application. In pharmaceutics, b-CD is used to increase solubility and stability3. We have prepared the inclusion compound of Andro/b-CD (Figure 2) under microwave irradiation4. It has been found…     

线性常微分方程(组)的算子方法介绍及其研究展望

综述了线性微分方程(组)的算子方法,侧重地介绍了作者所发展的一系列方法和重要的结果与解公式.提出了算子方法研究的几点展望.     

DSC and NMR Study on the Inclusion Complex of Lappaconitine with b-Cyclodextrin

Lappaconitine (Figure 1) is a diterpenoid alkaloid, naturally occurring in roots and rhizomes of Aconitum and delphinium1. Lap reveals bradycardic and hypotensive activity2. But its application is restrained owing to its poor water solubility, toxicity and side effects on humans. In a number of pharmaceutical studies, b-CD has been reported to interact with many drug molecules to form inclusion complexes for improving the water solubility of drugs, and reducing their toxicity3. We have p…     

Novel Stereoselective Synthesis of (E)-a,b-Unsaturated Esters by the Tandem Reaction of Deprotonation-Oxidation-Wittig Reaction from Phosphonium and Arsonium Salt

Wittigreactionisoneofthemostimportantmethodfortheformationofcarbon-carbondoublebondandhasbeenwidelyusedinthesynthesisofnaturalproducts1,2.Recentlyitwasfoundthatalcoholscanundergoinsituoxidation-Wittigreactionwithphosponiumylidestogivecorrespondingolefinationproducts,whichhasgreatpotentialutilitiesinorganicsynthesis3.Tosimplifytheprocedureofthereactionfurther,weconsideredtocombinethedeprotonationofylide,oxidationofalcoholandWittigreactionintoonetandemreaction.Weutilizedphosphoniumorarsoniumsal…     

ISO/TC43/WG1/ISO/TC43/SC1,ISO/TC43系列会议简介

一、概况 受国家技术监督局委派,我于1991年12月7—14日赴澳大利亚悉尼出席ISO/TC43(声学委员会)、TC43/SC1(噪声分会)、TC43/WG1(听阈工作组)会议。各会在悉尼北区的“标准楼(Standards House)举行。本次系列会议时间为12月5日—12日。 二、TC43/WG1会议 1987年4月初,我在巴黎召开的OIML(国际法制计量组织)的《声学、听力、振动》指导秘书处会上,曾发表了关于有关听力的国际标准中应把标准年龄由     

聚酰亚胺对多官能团环氧树脂的增韧作用

本文选择不同比例的聚酰亚胺(PEI)与多官能团的环氧树脂(MY0510)和 NovoIak 树脂(DEN431)共混,以3,3′—二氨基二苯亚砜(DDS)为固化剂,制备一系列的共混物样品。通过三点弯曲试验、扫描电镜和动态力学热分析分别测定共混物的应力强度因子(K_(1c))和临界应变能松驰速率(G_(1c))、形态结构和玻璃化转变温度。当加入 PEI 时,共混物的 K_(1C)和 G_(1C)都有显著的提高,即增加了环氧树脂的韧性。虽然所有共混物只有一个Tg 峰,但电镜的观察结果说明为两相结构。当 PEI 的含量为10%时,PEI 开始从分散相转变为连续相。后固化作用使 Tg 提高了6—20℃,同时也有利于 K_(1C)和 G_(1C)。