THE ACTION MODE OF CISPLATIN ON DNA-SYNTHESIS AND CHARACTERIZATION OF N7 N1 CROSS-LINKAGE MODEL COMPOUND OF PLATINUM AND GUANOSINE

The title Pt-Guo compound was synthesized and isolated by the reaction between cis-[Pt(NH3)2(H2O)2](NO3)2 and guanosine of mol ratio1:1 in a neutral aqueous solution followed by careful purification with partial crystalization and recrystallizatlon from water at 0℃.The compound was characterized by elemental analysis,molecular weight determination,DTA,and C NMR spectroscopy and its formulawas found to be [8(GuoH-1)7 (OH)2] (NO3)7 8H2O.The isolation of the compound provides direct evidence for the intrastrand cross-linkage between cisplatin and DNA through N7,N1 atoms of two adjacent guanines.     

气相色谱法研究配位化合物的热稳定性(Ⅶ)——Ni(Ⅱ)、Co(Ⅱ)草酸配合物的热分解及产物的催化性能

镍(Ⅱ)、钴(Ⅱ)草酸配合物在氢气中热分解时产生CO₂和CO,并发生加氢催化反应.CoC₃O₄和NiC₂O₄的分解产物CO₂加氢活性很快降低;K₂O等具有分散金属的作用。CoC₂O₄/Al₂O₃和K₂^{[Co(C₂O₄)₂]}/Al₂O₃体系具有Al₂(C₃O₄)₃的分解特征。C₂O₄^2-在Al₂O₃表面能形成表面配合物,在Al₂O₃表面Co(Ⅱ)的还原较为困难。