THE ACTION MODE OF CISPLATIN ON DNA-SYNTHESIS AND CHARACTERIZATION OF N7 N1 CROSS-LINKAGE MODEL COMPOUND OF PLATINUM AND GUANOSINE |
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| Authors: | Qu Yun Tang Wenxia Dai Anbang |
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| Institution: | Coordination Chemistry Research Institute of Nanjing University, Nanjing |
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| Abstract: | The title Pt-Guo compound was synthesized and isolated by the reaction between cis-Pt(NH3)2(H2O)2]·(NO3)2 and guanosine of mol ratio1:1 in a neutral aqueous solution followed by careful purification with partial crystalization and recrystallizatlon from water at 0℃.The compound was characterized by elemental analysis, molecular weight determination, DTA, and C NMRspectroscopy and its formulawas found to be 3)2>8(GuoH-1)7 (OH)2] (NO3)7 8H2O.The isolation of the compound provides direct evidence for the intrastrand cross-linkage between cisplatin and DNAthrough N7, N1 atoms of two adjacent guanines. |
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