Synthesis and characterization of insulin-5-Fu conjugate,enabling insulin as multi-drug carrier via dendritic approach

To enable insulin as multi-drug carrier, we designed and synthesized dendritic linker molecule bearing three 5-Fluorouracil residues at the branch ends. The new conjugate showed excellent water solubility. The stabilities under different conditions were investigated. The results showed that the conjugate was a potential prodrug to release free 5-Fu.     

模糊数学在城镇经济发展条件评价中的应用

本文应用模糊数学理论，对城镇在区域经济发展中的地位进行了定量的综合评价研究，文中的实例分析表明该模型的建立与应用是有效可行的．     

Capillary electrophoresis with direct chemiluminescence detection for the analysis of catecholamines in human urine

A rapid and sensitive method for the analysis of three catecholamines by capillary electrophoresis(CE)with directchemiluminescence(CL)detection is described.The detection limits(S/N=3)were 1.3*10-8g/mL for isoprenaline,1.0*10-8g/mL for epinephrine and 2.8*10-8g/mL for dopamine.The proposed method was successfully applied to theanalysis of catecholamines in urine samples of cigarette smokers and nonsmokers.The results showed that there is a close relationbetween the release of dopamine in human body fluids and cigarette smoking/nonsmoking.     

Structural Study of Inclusion Complex of Andrographolide with β-Cyclodextrin Prepared under Microwave Irradiation

Andrographolide (Andro) (Figure 1) is a diterpene lactone isolated from Andrographis paniculate Nees1. It has showed several biological activities including analgesic, antipyretic and anti-inflammatory effects2. However, its poor water solubility and unstability towards oxygen restrained its application. In pharmaceutics, b-CD is used to increase solubility and stability3. We have prepared the inclusion compound of Andro/b-CD (Figure 2) under microwave irradiation4. It has been found…     

DSC and NMR Study on the Inclusion Complex of Lappaconitine with b-Cyclodextrin

Lappaconitine (Figure 1) is a diterpenoid alkaloid, naturally occurring in roots and rhizomes of Aconitum and delphinium1. Lap reveals bradycardic and hypotensive activity2. But its application is restrained owing to its poor water solubility, toxicity and side effects on humans. In a number of pharmaceutical studies, b-CD has been reported to interact with many drug molecules to form inclusion complexes for improving the water solubility of drugs, and reducing their toxicity3. We have p…     

Novel Stereoselective Synthesis of (E)-a,b-Unsaturated Esters by the Tandem Reaction of Deprotonation-Oxidation-Wittig Reaction from Phosphonium and Arsonium Salt

Wittigreactionisoneofthemostimportantmethodfortheformationofcarbon-carbondoublebondandhasbeenwidelyusedinthesynthesisofnaturalproducts1,2.Recentlyitwasfoundthatalcoholscanundergoinsituoxidation-Wittigreactionwithphosponiumylidestogivecorrespondingolefinationproducts,whichhasgreatpotentialutilitiesinorganicsynthesis3.Tosimplifytheprocedureofthereactionfurther,weconsideredtocombinethedeprotonationofylide,oxidationofalcoholandWittigreactionintoonetandemreaction.Weutilizedphosphoniumorarsoniumsal…     

全息光学透镜研制中的理论初步分析

在研制全息光学透镜过程中,我们对不同全息乳胶特性进行了研究,除在单色光下再现外,又尝试了白光的再现,并取得了初步效果。在研制全息光学透镜时,采取了两种类型,即共轴型和离轴型,所用的光路中有会聚光束、平行光束。     

一元二次方程问题中几个易忽视的隐含条件

一元二次方程问题中,往往有一些容易被忽视的条件隐含其中,解题时若忽视这些隐含条件,则可导致错解.本文列举并剖析此类问题中的常见错解,希望引起大家的注意. 一、用判别式解题时忽视二次项系数不为零 例1 已知关于x的一元二次方程(m 2)x2 2x-1=0有两个不相等的实数根,求m的取值范围. (2000年云南省中考题) 锗解由题意得△=22-4(m 2)·(-1)>0,∴m>-3. 剖析本题错在只考虑方程有两个不相     

Zm环上线性组合引理的证明

本文证明了样本空间Ω=Z^nm上m值随机变量Z，与k个互相独立且分布均匀的m值随机变量Y1，…，Yh统计独立的充分必要条件，是Z与Y1，…，Yh的所有非零线性组合λ1Y1 … λhYh统计独立，其中λi∈Zm，i=1，…，m．     

A Movable Mass Spectroscopy Sampling Apparatus for Measuring Spatial Distribution of Neutral Radicals in Silane Plasma

A movable mass spectroscopy gas sampling apparatus has been established and a straight-line fit of silane depletion fraction f is proposed. The spatial density distributions of SiHn (n=0-3) radicals in silane radio frequency glow discharge have been measured by a mass spectrometer. The experimental results demonstrate that the densities of the neutral radicals have the peak value near the middle position of electrodes, and the densities of SiH2 and SiH3 are higher than those of Si and SiH in silane plasma. This reveals that SiH2 and SiH3 may be the primary precursors in forming the a-Si:H film.