（3-氧代苯并异噻唑啉-2-基）羧酸烷酯的合成及抑菌活性研究

以1,2-苯并异噻唑啉-2（3H）-酮为原料,通过＂一锅法＂制备了8种（3-氧代苯并异噻唑啉-2-基）羧酸烷酯,结构经IR、1H NMR和元素分析确认。抑菌活性实验表明,化合物在浓度为2mg/L时对亚心型扁藻、球等鞭金藻和蛋白核小球藻的生长都有抑制活性,其中部分化合物（2c～2h）对球等鞭金藻和蛋白核小球藻的生长有优良...     

Mannich Base Derivatives of 1,2-Benzisothiazolin-3-one: Syntheses,Crystal Structures and Bioactivities

Twelve Mannich base derivatives of 1,2-benzisothiazolin-3-one were synthesized by the reaction of 1,2-benzisothiazol-3(2H)-one(BIT) with different amines and formaldehyde. All the compounds were characterized by elemental analysis, IR spectroscopy, MS and 1H NMR. The crystal structure for 2,2'-methylenebis(benzo[d]isothiazol-3(2H)-one)(3) has been determined by X-ray single-crystal structure analysis. Compound 3(C15H10N2O2S2) crystallizes in the monoclinic system, space group C2/c with a = 25.052(8), b = 4.510(1), c = 11.948(4) , β = 100.992(4)o, V = 1325.2(7) 3, Mr = 314.37, Dc = 1.576 Mg·m-3, μ = 0.25 mm-1, F(000) = 648, Z = 4, R = 0.034 and wR = 0.087. The preliminary biological test indicated that the compounds(2b, 2c) showed growth inhibitory activity against the gram-positive and gram-negative bacteria.