Comparison of structure fingerprint and molecular interaction field based methods in explaining biological similarity of small molecules in cell-based screens

In this work, we calculated the pair wise chemical similarity for a subset of small molecules screened against the NCI60 cancer cell line panel. Four different compound similarity calculation methods were used: Brutus, GRIND, Daylight and UNITY. The chemical similarity scores of each method were related to the biological similarity data set. The same was done also for combinations of methods. In the end, we had an estimate of biological similarity for a given chemical similarity score or combinations thereof. The data from above was used to identify chemical similarity ranges where combining two or more methods (data fusion) led to synergy. The results were also applied in ligand-based virtual screening using the DUD data set. In respect to their ability to enrich biologically similar compound pairs, the ranking of the four methods in descending performance is UNITY, Daylight, Brutus and GRIND. Combining methods resulted always in positive synergy within a restricted range of chemical similarity scores. We observed no negative synergy. We also noted that combining three or four methods had only limited added advantage compared to combining just two. In the virtual screening, using the estimated biological similarity for ranking compounds produced more consistent results than using the methods in isolation.     

半导体激光牙科治疗仪

采用ＧａＡｌＡｓ激光二极管作为激光源，电子定时，功率实时监测，ＬＥＤ红光指示，硬光纤偶合输出，工作波长８３０ｎｍ，输出功率１３０ｍＷ，属于低功率激光，主要产生刺激调理作用，消炎止痛，抗感染，改善血液循环，增强机体免疫功能     

瞄准制导仪中的调制盘光学系统分析

瞄准制导仪中的调制盘光学系统包含有光束投射系统、光束投影系统和旋转调制盘。基于旋转调制盘图案设计的原理,分析了瞄准制导仪中内、外调制图案与光学系统的配合问题。较详细地分析了激光束投射系统和投影系统。     

空心束虚阴极激励微波的主模式的研究

把虚阴极振荡激励微波的过程看成是一个时空振荡电流元激励微波的过程,在薄电荷层近似下,求得空心束虚阴极激励微波的主模式关系,并讨论了束几何位形与微波输出功率之间的关系。我们所确定的主模式与实验和粒子模拟的结果相符。     

The principle of virtual work in mechanical and electromechanical systems

Summary The principle of virtual work is applied to electromechanical systems as the foundation of a unifying concept for modelling mechatronical systems. After the presentation of an important result in the field of mechanics, the expansion of the principle on electrical networks and electromechanical systems is shown. The use of the principle of virtual work in the domain of electromechanics yields an analogous form to the central equation of mechanics which is valid for holonomic and nonholonomic systems. The electrotechnical part of the system is confined to networks. The derivation of the mathematical model is demonstrated on the example of a simple electromechanical oscillation circuit. In addition, the physical systems are separately treated, taking into account the explicit constraints on the basis of the Lagrangian multiplier method.     

同轴虚阴极振荡器实验研究

 介绍了中国工程物理研究院应用电子学研究所关于同轴虚阴极振荡器实验的最新进展。实验结果表明，带阳极反射板结构的同轴虚阴极振荡器比不带阳极反射板结构的同轴虚阴极振荡器输出微波功率更高，频谱更纯。在二极管电压350 kV，电流23 kA条件下，输出微波峰值功率500 MW，能量转换效率约6.2%，工作频率为3.3 GHz。对实验结果进行了理论分析。     

Virtual Source of a Swallowtail Beam

By applying a virtual source method, the exact and the paraxial solutions of the Swallowtail beams (SBs) that are governed by the inhomogeneous Helmholtz equation are introduced. The paraxial SBs generated experimentally possess both self-accelerating and self-focusing features. The parameters controlling the field distributions are discussed in theory. From the spectral representation of the Swallowtail wave, in the appropriate limit, the first four terms of the nonparaxial correction series for the (1+2)-dimensional Swallowtail waves that simplify to the SBs are obtained.     

虚边界元法的应用及其求解方法

由弹性力学问题的虚边界元方法出发，给出若干算例，对基在接触，塑性，蠕变等非线性问题中的应用，做了进一步探讨，提出了相应的求解方案。     

软岩流变的一种新的试验研究方法

 研制了用于软岩流变的蠕变-松弛耦合试验仪，探讨了利用单级 加载和逐级加载两种方式确定软岩流变参数和长期强度的蠕变-松弛耦 合试验原理. 有关的具体试验表明，该仪器操作简便, 稳定性好，所得 结果客观、可靠，可在工程中推广应用.     

剪切弯曲下短深梁位移数值计算精度的研究

分析了短深梁位移的基本解，评述了有限元解法中关于高次分布力简化为节点力的问题。使用虚功原理和位移线性插值推导了满足二次分布力作用的精确节点力分配公式。通过矩形截面悬臂梁自由终端受集中载荷的算例，阐明了提高短深梁位移计算精度的途径。