Crystal structure and spectroscopic study of di-μ(1,1)-azido-di-μ(0,0-nitrato)tetrakis(3,5-lutidine)dicopper(II), [Cu(N3) (NO3) (3,5-lutidine)2]2

A mixed ligand 12 complex of copper(II) azide with 3,5-lutidine, namely di-(1,1)-azido-di(0,0)-nitrato)tetrakis(3,5-lutidine)dicopper(II) has been prepared and characterized by X-ray crystallographic and spectroscopic methods. The dimeric molecule, which possesses a crystallographic inversion center, contains two(1,1) bridging azido ligands. Each copper(II) atom in the cyclic Cu₂N₂ unit is further coordinated by two oxygen atoms from two(0,0-nitrato) bridges at Cu-O distances of 2.465(3) and 2.568(3) Å and two nitrogen atoms from the lutidine molecules [Cu-N=2.003(3) and 2.012(3) Å] to give a distorted tetragonal bipyramid. Both azido ligands are linear [N-N-N angle=179.0(4) and asymmetric N-N=1.207(4) and N-N=1.135(5) Å]. The azido bridges produce a rather short Cu Cu distance of 3.013(2) Å. Infrared and electronic data are presented and discussed.     

Solvent Effects on the Structure-Activity Relationship of Pharmacological Active 3-Substituted-5,5-Diphenylhydantoins

Absorption spectra of eight 3-substituted-5,5-diphenylhydantoins have been recorded in fourteen solvents in the range 200–400 nm. The effect of solvent dipolarity/polarizability and solvent/solute hydrogen bonding interactions are analyzed by means of the linear solvation energy relationship (LSER) concept proposed by Kamlet and Taft. The lipophilic activity of the investigated hydantoins was estimated by the calculation of log ₁₀ P values with the Advanced Chemistry Development Software. The calculated values of log ₁₀ P were correlated with the ratio of the contributions of specific solvent interactions, and, by employing the linear dependence thus obtained, the pharmacological activity of the studied hydantoin derivatives is discussed.     

Prediction of soil organic carbon partition coefficients by soil column liquid chromatography

To avoid the limitation of the widely used prediction methods of soil organic carbon partition coefficients (KOC) from hydrophobic parameters, e.g., the n-octanol/water partition coefficients (KOW) and the reversed phase high performance liquid chromatographic (RP-HPLC) retention factors, the soil column liquid chromatographic (SCLC) method was developed for KOC prediction. The real soils were used as the packing materials of RP-HPLC columns, and the correlations between the retention factors of organic compounds on soil columns (ksoil) and KOC measured by batch equilibrium method were studied. Good correlations were achieved between ksoil and KOC for three types of soils with different properties. All the square of the correlation coefficients (R2) of the linear regression between log ksoil and log KOC were higher than 0.89 with standard deviations of less than 0.21. In addition, the prediction of KOC from KOW and the RP-HPLC retention factors on cyanopropyl (CN) stationary phase (kCN) was comparatively evaluated for the three types of soils. The results show that the prediction of KOC from kCN and KOW is only applicable to some specific types of soils. The results obtained in the present study proved that the SCLC method is appropriate for the KOC prediction for different types of soils, however the applicability of using hydrophobic parameters to predict KOC largely depends on the properties of soil concerned.     

钇离子及其阳离子卟啉配合物与金黄色葡萄球菌的相互作用

用LKB-2277生物活性检测系统考察了Y~(3+)，TMP及其阳离子型钇卟啉配合物 {[Y(TMP)(H_2O)_3]Cl, TMP = 5, 10, 15, 20-四（4-甲氧基苯基）卟啉}对金黄色 葡萄球菌全程代谢作用的影响，测定了Y~(3+)，TMP和[Y(TMP)(H_2O)_3]Cl对金黄 色葡萄球菌作用的产热曲线，根据产热曲线求算了金黄色葡萄球菌在Y~(3+)，TMP ，[Y(TMP)(H_2O)_3]Cl作用下生长代谢的速率常数k_1，k_2，抑制率I_1，I_2，和 半抑制浓度IC_(50)~1，IC_(50)~2等热动力学参数。实验结果表明：Y~(3+)，[Y (TMP)(H_2O)_3]Cl对金黄色葡萄球菌的生长代谢有双向调节作用，在低浓度下表现 为刺激作用，高浓度为抑制作用，而TMP对金黄色葡萄球菌的生长代谢主要为抑制 作用，在低浓度下表现为刺激作用，高浓度为抑制作用，而TMP对金黄色葡萄球菌 的生长代谢主要为抑制作用，对金黄色葡萄球菌的抑制作用[Y(TMP)(H_2O)_3]Cl > TMP > Y~(3+)。     

Solubility and Flory Huggins parameters of SBES, poly(styrene-b-butene/ethylene-b-styrene) triblock copolymer, determined by intrinsic viscosity

Solubility parameter and Flory Huggins interaction parameter of a triblock SBES have been obtained from intrinsic viscosity measurements. The solubility of the block copolymer in all solvents (methyl-cyclohexane, cyclohexane, cyclopentane, toluene and benzene) was found good except in the case of n-hexane. The results obtained are similar to other found in literature for SBR and SBS rubbers, and indicate that cyclohexane and cyclopentane and methylcyclohexane are the most compatible solvents for this kind of polymer.     

Study on the Binding Effect between Cordycepin and Calf Thymus DNA by Circular Dichroism

DNA works as hereditary material and plays vital role in life science. The study of the binding of small molecules complex to DNA has been the focus of intense investigation, owning to their stereo and sequence specific interaction with the double helix1-…     

STABILITY OF POLY（N,N＇-METHYLENEBISACRYLAMIDE-co-4-VINYLPYRIDINE） MICROGEL DISPERSION AND ADJUSTMENT OF THE HYDROPHOBICITY IN THE MICROGELS

In the UV-Vis spectra of pure light-scattering systems, there is an exponential relationship between absorbance and wavelength （A = Kλ^-n）. Here, the exponent n is named as flocculation-coagulation parameter. In the present paper, the effects of different additives on the stability of poly（N,N＇-methylenebisacrylamide-co-4-vinylpyridine） （poly（Bis-co-4-VP）） microgel dispersion were studied in detail via this parameter. The results showed that the stability of the dispersion mainly comes from the ionization of pyridine groups, making the microgel positively charged on its surface. This was confirmed by the measurement of Zeta potential and the result of conductometric titration. The result of fluorescence analysis indicated that the hydrophobicity in the microgels is enhanced with the increase in total 4-VP unit content.     

Retention of ionizable compounds on HPLC. Modelling retention for neutral and ionizable compounds by linear solvation energy relationships

Summary A global LSER model that relates HPLC retention to mobile phase composition and pH is tested for a varied group of solutes, both neutral and ionizable, in a polymeric column and methanol-water mobile phases. It is compared to the local LSER model developed only for a given mobile phase, i.e., a fixed organic modifier content, and to the global LSER model set only for neutral solutes. The global LSER model for neutral and ionizable solutes requires a few supplementary parameters over the other models tested, but it accounts for retention under any experimental conditions for a given column and methanol-water mobile phases, describing properly the interactions established in the HPLC system (hydrophobicity, hydrogen-bond acidity and basicity, dipolarity/polarizability…). This paper is number 13 of a series with the same general title: “Retention of Ionizable Compounds on HPLC” published in various journals.     

Characterization of a convection-based support microstructure through a flow resistance parameter

Modern convection-based supports differ substantially in pore size, porosity, and microstructure topology. Due to such variability, it is challenging to evaluate the contribution of a particular microstructure topology on flow resistance. We demonstrated that the flow resistance parameter ($\varphi$) introduced decades ago can be used as a criterion to evaluate the effect of microstructure topology on a pressure drop when the pore size is used as a characteristic support dimension. Furthermore, the $\varphi$ value of simple cubic packing was calculated over the entire range of open porosity and compared to the $\varphi$ values determined for pressure drop models derived for particular convection-based supports and experimental values of various convection-based supports from the literature. It was shown that different convection-based supports become clustered into distinct groups when plotted according to their $\varphi$ and open porosity values, allowing their discrimination.