| Study on the Binding Effect between Cordycepin and Calf Thymus DNA by Circular Dichroism |
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| 作者姓名： | Jian Ya LING Jian Qun LIN Guo Ying ZHANG[ ] Chang Kai ZHANG |
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| 作者单位： | Jian Ya LING1*，Jian Qun LIN1*，Guo Ying ZHANG2，3，Chang Kai ZHANG1 1State Key Laboratory of Microbial Technology，Shandong University，Jinan 250100 2Traditional Chinese Medicine of Shandong University，Jinan 250014 3School of Environmental Science and Engineering，Shandong University，Jinan 250100 |
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| 摘 要： | DNA works as hereditary material and plays vital role in life science. The study of the binding of small molecules complex to DNA has been the focus of intense investigation, owning to their stereo and sequence specific interaction with the double helix1-…
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| 关 键 词： | 蛹虫草菌素 DNA粘合物 CT-DNA 结构 分光光谱分析 循环二色性 |
| 收稿时间： | 05 10 2006 12:00AM |
Study on the Binding Effect between Cordycepin and Calf Thymus DNA by Circular Dichroism |
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| Jian Ya LING Jian Qun LIN Guo Ying ZHANG, Chang Kai ZHANG.Study on the Binding Effect between Cordycepin and Calf Thymus DNA by Circular Dichroism[J].Chinese Chemical Letters,2006,17(10):1351-1352. |
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| Authors: | Jian Ya LING Jian Qun LIN Guo Ying ZHANG Chang Kai ZHANG |
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| Abstract: | Binding of cordycepin to the double helical DNA with a high affinity was investigated by CD spectra in this paper. The results proved that uncoiling, unbinding and denaturation of DNA proceeded continuously upon the increase of the concentration of cordycepin. |
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| Keywords: | Cordycepin DNA-binding CT-DNA conformation spectroscopic technique |
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