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81.
《中国化学快报》2020,31(5):1168-1172
Near-infrared (NIR) light-triggered photothermal therapy (PTT) is a promising treatment strategy for treating cancer. The combination of nanotechnology and NIR has been widely applied. However, the therapeutic efficacy of the drug-delivery system depends on their ability to avoid phagocytosis of endothelial system, cross the biological barriers, prolong circulation life, localize and rapidly release the therapeutic at target sites. In this work, we designed a platelet membrane (PM)-camouflaged hollow mesoporous bismuth selenide nanoparticles (BS NPs) loading with indocyanine green (ICG) (PM@BS-ICG NPs) to achieve the above advantages. PM-coating has active tumor-targeting ability which could prevent drug leakage and provide drug long circulation, causing drug delivery systems to accumulate in tumor sites effectively. Moreover, as a type of the photothermal sensitizers, BS NPs are used as the inner cores to improve ICG stability and are served as scaffolds to enhance the hardness of this drug delivery system. For one hand, the thermal vibration of BS NPs under NIR laser irradiation causes tumor inhibition through hyperthermia. For another hand, this hyperthermia process could damage PM and let ICG rapid release from PM@BS-ICG NPs. The in vitro and in vivo results showed that this biomimetic nano-drug delivery system exhibits obvious antitumor activity which has good application prospect. 相似文献
82.
TheBeckInannrearrangement,theacid-mediatedisomerizationofoximestoamides,wasfirstdiscoveredinl886l.Asoneoftheoldestandmostfamiliartransformationsinorganicchemistry,ithasbeenwidelystudiedandagreatvarietyofmethodstoconductthistfansformationhavebeenreported'.However,mostofthesemethodswerecarriedoutbyusingalargeamountofsolventswithlongreactiontime.Whatismore,thepriorpreparationofthecorrespondingketoximesisusuallyrequired,whichmakestheseprocessesinconvenientandlessattractive.Bytakingadvantageofboth… 相似文献
83.
Mahrour A. Lacroix M. Nketsa-Tabiri J. Calderon N. Gagnon M. 《Radiation Physics and Chemistry》1998,52(1-6):81-84
This study was undertaken to determine if a combined treatment (marinating in natural plant extracts or vacuum) with irradiation could have a synergetic effect, in order to reduce the dose required for complete elimination of Salmonella on fresh poultry. The effect of these combined treatments on the shelf-life extension was also evaluated. The fresh chicken legs were irradiated at 0, 3 and 5 kGy. The poultry underwent microbial analysis(mesophilic and Salmonella detection). For each treatment, the total microbial count decreased with increase of irradiation dose. The marinating treatment have a synergistic effect with irradiation treatment to reduce the total microbial count and controlling the proliferation during storage at 4°C. Irradiation of fresh chicken pieces with a dose of 3 kGy appears to be able to extend the microbial shelf-life by a factor of 2. When the chicken is marinating and irradiated at 3 kGy or when irradiated at 5 kGy without marinating, the microbial shelf-life is extended by a factor of 7 to 8. No Salmonella was found during all the experiment in the chicken in air and marinated. However, a presence of Salmonella was found in samples irradiated at 5 kGy under vacuum, in unirradiated samples and samples irradiated at 3kGy in air and under vacuum. 相似文献
84.
The boxes contained kiwifruits were irradiated with cobalt-60 γ-rays at different dosages (0.6 , 1.8 and 3.6 KGy) and stored in a room ventilated at night, the natural ambient air being used as cool source.The results showed that the treatment which fruits irradiated with 0.6 KGy was the best after 85 days. It gave the normal-fruit rate of 95.10%, fruit flesh hardness of 4.10 Kg · cm-2, fresh and plump fruits, good quality and less Vc loss. 相似文献
85.
Shyh-Horng Chiou 《中国化学会会志》1989,36(5):435-442
A rapid peptide-bond hydrolysis by means of microwave irradiation is introduced for the facile preparation of protein hydrolysates used for amino acid analysis. The optimal hydrolysis condition has been determined using several enzymes with known amino acid compositions. The effects of hydrolysis time on the recovery of various labile and hydrophobic amino acids are also exemplified in the microwave heating of standard amino acids. The method has been applied to the complete amino acid analysis with a single nonvolatile solvent of methanesulfonic acid with good recovery of tryptophan and half-cystine. It provides a radical expedition of protein and peptide hydrolysis via commercial microwave ovens and specially-designed Teflon-Pyrex tubes, circumventing the tedious procedures using vacuum-sealed pyrex lubes heating at 110°C for more than 24 h. This novel type of microwave chemistry associated with rapid peptide-bond cleavage is of great potential in the automation of the complete process of amino acid analysis starting from the preparation of protein hydrolysates. 相似文献
86.
羧甲基纤维素系列高分子表面活性剂超声合成的研究 总被引:27,自引:2,他引:27
研究了在超声波作用下羧甲基纤维素的降解反应及CMC与具有不同亲水亲油比值的活性大单体「烷基醇(酚)聚氧乙烯醚丙烯酸酯及第三单体」的超声共聚反应。经萃取提纯的共聚产物用IR,^13C NMR和UV等方法进行表证,证实通过超声反应制得了二元和三元共聚物。 相似文献
87.
Xue Yuan HU Xue Sen FAN Xin Ying ZHANG Gui Rong QU Yan Zhen LI School of Chemical Environmental Sciences Henan Key Laboratory for Environmental Pollution Control Henan Normal University Xinxiang Chongqing University of Medical Sciences Chongqing 《中国化学快报》2005,(7)
Construction of tetrahydropyran rings has attracted a great deal of interests in organic synthesis in recent years1, since tetrahydropyran moiety constitutes a structural unit in a number of natural products2. In addition, tetrahydropyran derivatives possess wide range of biological activities and pharmacological properties, such as anticancer activity3 and antihypersensitivity4. Many methods for the preparation of such compounds have already been developed5. Among them, condensation of α, β… 相似文献
88.
Rahman Hosseinzadeh Ali Sharifi Kourosh Tabar-Heydar Farshid Mohsenzadeh 《Monatshefte für Chemie / Chemical Monthly》2002,133(11):1413-1415
Summary. N,N-Dimethylhydrazones of ketones and aldehydes undergo facile cleavage to the corresponding carbonyl compounds upon exposure
to microwaves in water containing a catalytic amount of PdCl2–SnCl2 in high yields.
Corresponding authors. E-mail: rahman@umz.ac.ir
Received December 27, 2001. Accepted (revised) February 6, 2002 相似文献
89.
An efficient method for the oxidation of benzylic alcohols with [hydroxy(tosyloxy)iodo]benzene under solvent-free microwave irradiation conditions is described. 相似文献
90.