NIR light-induced tumor phototherapy using ICG delivery system based on platelet-membrane-camouflaged hollow bismuth selenide nanoparticles |
| |
| Institution: | 1. School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China;2. School of Pharmacy, Xinxiang Medical University, Xinxiang 453000, China;3. Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou 450001, China;2. Department of Chemistry, Xinxiang Medical University, Xinxiang, Henan 453003, PR China;3. School of Chemistry and Materials Science, University of Science and Technology of China, Hefei 230026, PR China;1. Department of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA;2. Department of Pharmaceutics, School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education, Shanghai 201203, PR China;1. Department of Radiology, Shanghai Tenth People''s Hospital, School of Medicine, Tongji University, Shanghai, 200072, China;2. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai, 201620, China;3. Department of Ophthalmology, Shanghai Tenth People''s Hospital, School of Medicine, Tongji University, Shanghai, 200072, China;1. Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Henan Key Laboratory of Green Chemical Media and Reactions, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, PR China;2. Department of Chemistry and Laboratory of Advanced Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200438, PR China |
| |
| Abstract: | Near-infrared (NIR) light-triggered photothermal therapy (PTT) is a promising treatment strategy for treating cancer. The combination of nanotechnology and NIR has been widely applied. However, the therapeutic efficacy of the drug-delivery system depends on their ability to avoid phagocytosis of endothelial system, cross the biological barriers, prolong circulation life, localize and rapidly release the therapeutic at target sites. In this work, we designed a platelet membrane (PM)-camouflaged hollow mesoporous bismuth selenide nanoparticles (BS NPs) loading with indocyanine green (ICG) (PM@BS-ICG NPs) to achieve the above advantages. PM-coating has active tumor-targeting ability which could prevent drug leakage and provide drug long circulation, causing drug delivery systems to accumulate in tumor sites effectively. Moreover, as a type of the photothermal sensitizers, BS NPs are used as the inner cores to improve ICG stability and are served as scaffolds to enhance the hardness of this drug delivery system. For one hand, the thermal vibration of BS NPs under NIR laser irradiation causes tumor inhibition through hyperthermia. For another hand, this hyperthermia process could damage PM and let ICG rapid release from PM@BS-ICG NPs. The in vitro and in vivo results showed that this biomimetic nano-drug delivery system exhibits obvious antitumor activity which has good application prospect. |
| |
| Keywords: | Platelet membrane Biomimetic nanoplatform Photothermal therapy Tumor-targeting Near-infrared laser irradiation |
| 本文献已被 维普 ScienceDirect 等数据库收录！ |
|
