Identification of key classification features of early cervical squamous cell carcinoma

Despite the tremendous progress in molecular analysis of pan-cancer, little is known regarding molecular classification of cervical squamous cell carcinoma. In this study, we adopted a multi-omics approach to identify potential key classification features of cervical squamous cell carcinoma. Specifically, we analyzed mRNA, and microRNA (miRNA) expression data, as well as DNA methylation and copy number variation in cervical squamous cell carcinoma cases, using datasets obtained from The Cancer Genome Atlas (TCGA). Moreover, we identified molecules in each dimension, as well as integrated and clustered filtered classification features, and used them to distinguish different subtypes. The resulting key classification features were used to establish a classification model for cervical squamous cell carcinoma. Our results revealed two cervical squamous cell carcinoma subtypes, with significant differences across clinical survival levels, as well as 8 key classification features of cervical squamous cell carcinomas. These findings are expected to provide important references for early classification of cervical squamous cell carcinoma and identification of classification markers.     

Metabolic characterization of the early stage of hepatic fibrosis in rat using GC‐TOF/MS and multivariate data analyses

The aim of this study was to explore the changes in the urine metabolic spectrum in rats with the early stage of liver fibrosis using gas chromatography–time of flight/mass spectrometry (GC‐TOF/MS), try to search for potential biomarkers and elucidate the probably metabonomic pathogenesis. The early stage of liver fibrosis was established with a single subcutaneous injection of carbon tetrachloride twice each week for 4 weeks continuously. At the end of the experiment, GC‐TOF/MS technology with multivariate statistical approaches such as principal component analysis, partial least squares‐discriminant analysis and orthogonal partial least squares‐discriminant analysis was used to analyze the changes in the metabolic spectrum trajectory and identify potential biomarkers. Twelve potential biomarkers in the model group, such as succinic acid, threonine and lactose, were selected, which indicate that the metabonomic pathogenesis of the early stage of liver fibrosis may be related to disorders of energy metabolism, amino acid metabolism and fatty acid metabolism.     

快脉冲直线变压器驱动源模块的原理及实验

 介绍了直线型变压器驱动源（LTD）产生快脉冲的基本原理及技术优势，阐述了快脉冲LTD模块设计的要点，设计了输出脉冲上升时间小于100 ns的快脉冲LTD模块，并进行了初步的实验研究。实验得到该LTD模块充电±16 kV时，短路放电的电流峰值为23.7 kA，电流振荡1/4周期为69.6 ns；充电±50 kV驱动0.85 Ω负载时，电流峰值为41.4 kA，上升时间为36.8 ns（10%~90%）和60.8 ns（0~100%）。     

A PREDATOR-PREY SYSTEM WITH STAGE STRUCTURE AND HARVESTING FOR PREDATOR

In this paper, we consider a predator-prey system with stage structure and harvesting (where the predator population has two stages, an immature stage and a mature stage with harvesting, and the growth of the prey population is of Lotka-Volterra nature). We obtain the conditions of the globally asymptotic stability for three nonne-gative equilibria of this system.     

On the iterative solution of the algebraic equations in fully implicit Runge-Kutta methods

This paper deals with the iterative solution of stage equations which arise when some fully implicit Runge-Kutta methods, in particular those based on Gauss, Radau and Lobatto points, are applied to stiff ordinary differential equations. The error behaviour in the iterates generated by Newton-type and, particularly, by single-Newton schemes which are proposed for the solution of stage equations is studied. We consider stiff systems y'(t) = f(t,y(t)) which are dissipative with respect to a scalar product and satisfy a condition on the relative variation of the Jacobian of f(t,y) with respect to y, similar to the condition considered by van Dorsselaer and Spijker in [7] and [17]. We prove new convergence results for the single-Newton iteration and derive estimates of the iteration error that are independent of the stiffness. Finally, some numerical experiments which confirm the theoretical results are presented. This revised version was published online in June 2006 with corrections to the Cover Date.     

Welcher Weg? A Trajectory Representation of a Quantum Young’s Diffraction Experiment

The double slit problem is idealized by simplifying each slit by a point source. A composite reduced action for the two correlated point sources is developed. Contours of the reduced action, trajectories and loci of transit times are developed in the region near the two point sources. The trajectory through any point in Euclidean 3-space also passes simultaneously through both point sources.     

检验两个部分线性模型中非参函数相等

We propose the test statistic to check whether the nonparametric func-tions in two partially linear models are equality or not in this paper. We estimate the nonparametric function both in null hypothesis and the alternative by the local linear method, where we ignore the parametric components, and then estimate the parameters by the two stage method. The test statistic is derived, and it is shown to be asymptotically normal under the null hypothesis.     

一类具有阶段结构和时滞的非自治捕食系统

本文研究一类具有阶段结构和时滞的非自治捕食系统解的渐近性质 ,在适当条件下 ,得到系统是持续生存的且全局渐近稳定的     

大剂量补充微量元素治疗“胃溃疡型腺癌伴广泛转移”一例

阐述了一例胃底溃疡型腺癌伴周边器官淋巴组织广泛转移患者，行“贲门MT术”姑息治疗后，经九个月大剂量多种微量元素制剂补充达到很好的临床效果。