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921.
A three-dimensional extension of two-dimensional digital image correlation has been developed. The technique uses digital image volumes generated through high-resolution X-ray tomography of samples with microarchitectural detail, such as the trabecular bone tissue found within the skeleton. Image texture within the material is used for displacement field measurement by subvolume tracking. Strain fields are calculated from the displacement fields by gradient estimation techniques. Estimates of measurement precision were developed through correlation of repeat unloaded data sets for a simple sum-of-squares displacement-only correlation formulation. Displacement vector component errors were normally distributed, with a standard deviation of 0.035 voxels (1.22 m). Strain tensor component errors were also normally distributed, with a standard deviation of approximately 0.0003. The method was applied to two samples taken from the thigh bone near the knee. Strains were effectively measured in both the elastic and postyield regimes of material behavior, and the spatial patterns showed clear relationships to the sample microarchitectures. 相似文献
922.
923.
The exposure of polymeric composite matrix to a cyclic moist environment produces transient residual stresses extremely important at the edges of the laminated plates, particularly at first times. In cases of critical cyclic environmental conditions, the damage of composites becomes very probable, so durability is intensively reduced. To avoid the damage probability, and to reduce the transient hygrothermal stresses, in our paper the hybrid composites with optimal stacking sequences are used. The first aim of this paper is the determination of hygrothermal characteristics for balanced stacking sequences [θ/−θ]nS. Therefore, in order to locate the favourite directions of each stacking sequence, the polar representation method is adopted. The suitable choice of hygrothermal characteristics, allows thereafter, the reduction of transient hygrothermal stresses. By using the quadratic failure criterion in stress space, the transient strength ratio is evaluated at first ply of the hybrid plate for each sequences [θ/−θ]nS from initial time until saturation time. Avoid the damage probability is reached by the reduction of transient hygrothermal stresses along the thickness of the hybrid plate. To locate the minimal and maximal stresses, a progressive variation of the relationship between the thicknesses h1 and h2 of hybrid composites constituents AS3501 and T300/5208 was carried out. In this way five cases are proposed, on which, the thickness of each material varies gradually, but the total thickness of our plate remains constant. This procedure permits us to find the best configuration which will offer favourable conditions of services, i.e., to predict a considerable reduction of hygrothermal transverse stresses at both edges of the hybrid plate. 相似文献
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926.
Arie Wibowo Gusti U. N. Tajalla Maradhana A. Marsudi Glen Cooper Lia A.T.W. Asri Fengyuan Liu Husaini Ardy Paulo J.D.S. Bartolo 《Molecules (Basel, Switzerland)》2021,26(7)
Electroactive biomaterials are fascinating for tissue engineering applications because of their ability to deliver electrical stimulation directly to cells, tissue, and organs. One particularly attractive conductive filler for electroactive biomaterials is silver nanoparticles (AgNPs) because of their high conductivity, antibacterial activity, and ability to promote bone healing. However, production of AgNPs involves a toxic reducing agent which would inhibit biological scaffold performance. This work explores facile and green synthesis of AgNPs using extract of Cilembu sweet potato and studies the effect of baking and precursor concentrations (1, 10 and 100 mM) on AgNPs’ properties. Transmission electron microscope (TEM) results revealed that the smallest particle size of AgNPs (9.95 ± 3.69 nm) with nodular morphology was obtained by utilization of baked extract and ten mM AgNO3. Polycaprolactone (PCL)/AgNPs scaffolds exhibited several enhancements compared to PCL scaffolds. Compressive strength was six times greater (3.88 ± 0.42 MPa), more hydrophilic (contact angle of 76.8 ± 1.7°), conductive (2.3 ± 0.5 × 10−3 S/cm) and exhibited anti-bacterial properties against Staphylococcus aureus ATCC3658 (99.5% reduction of surviving bacteria). Despite the promising results, further investigation on biological assessment is required to obtain comprehensive study of this scaffold. This green synthesis approach together with the use of 3D printing opens a new route to manufacture AgNPs-based electroactive with improved anti-bacterial properties without utilization of any toxic organic solvents. 相似文献
927.
928.
The present study deals with intensified synthesis of designer lipids with application of ultrasound based on biocatalyzed reaction between long chain triglyceride and medium chain fatty acid. The effects of various reaction conditions like molar ratio of reactant, reaction temperature, and enzyme loading along with the effect of ultrasound parameters such as duty cycle and irradiation time on the rate of formation of designer lipids has been investigated. The ultrasound assisted process was also compared with the traditional process so as to clearly bring out the intensification effects. During the study, it was clearly demonstrated that the optimum reaction conditions for maximum yield of designer lipids as 92% was molar ratio of medium chain fatty acid to long chain triglyceride as 4:1, reaction temperature of 40 °C, enzyme loading of 3%, duty cycle of 70%, 240 W as power dissipation and 360 min as reaction time. The recyclability study of enzyme showed its effectiveness up to 10 cycles. The synthesized designer lipid showed higher oxidative stability for 35 days and also showed Newtonian behaviour with eye appealing colour. The current study demonstrates development of an eco-friendly technique for intensified synthesis of designer lipids having numerous nutraceutical benefits. 相似文献
929.
《Macromolecular bioscience》2017,17(6)
Functionalizing polymer scaffolds with nanodiamond particles (nDPs) has pronounced effect on the surface properties, such as improved wettability, an increased active area and binding sites for cellular attachment and adhesion, and increased ability to immobilize biomolecules by physical adsorption. This study aims to evaluate the effect of poly(l ‐lactide‐co‐ε‐caprolactone) (poly(LLA‐co‐CL)) scaffolds, functionalized with nDPs, on bone regeneration in a rat calvarial critical size defect. Poly(LLA‐co‐CL) scaffolds functionalized with nDPs are also compared with pristine scaffolds with reference to albumin adsorption and seeding efficiency of bone marrow stromal cells (BMSCs). Compared with pristine scaffolds, the experimental scaffolds exhibit a reduction in albumin adsorption and a significant increase in the seeding efficiency of BMSCs (p = 0.027). In the calvarial defects implanted with BMSC‐seeded poly(LLA‐co‐CL)/nDPs scaffolds, live imaging at 12 weeks discloses a significant increase in osteogenic metabolic activity (p = 0.016). Microcomputed tomography, confirmed by histological data, reveals a substantial increase in bone volume (p = 0.021). The results show that compared with conventional poly(LLA‐co‐CL) scaffolds those functionalized with nDPs promote osteogenic metabolic activity and mineralization capacity. It is concluded that poly(LLA‐co‐CL) composite matrices functionalized with nDPs enhance osteoconductivity and therefore warrant further study as potential scaffolding material for bone tissue engineering.
930.
An injectable and biomimetic multi‐phase nanocomposite for non‐invasive bone tissue engineering: fabrication and mechanistic evaluation 下载免费PDF全文
An injectable, non‐hardening nanocomposite bone graft has been developed using a combination of nanohydroxyapatite as bioactive and osseointegrative material; P‐15 peptide‐modified poly(lactic‐co‐glycolic acid) (PLGA) microspheres as biomimetic and osteoinductive agent; and PLGA–poly(ethylene glycol) (PEG)–PLGA as a carrier gel. Increase in lactic acid/glycolic acid ratio of PLGA–PEG–PLGA resulted in stronger gels with a wider gelation window. Addition of 2.5‐fold nanohydroxyapatite resulted in significant changes in injectability (3.5‐fold force of injection), swelling characteristics (2.5 times swelling index), rheological (shear viscosity from 2.1 × 101 Pa s for NC3_700 to 1.5 × 106 Pa s for NC3_73.52 and from 3.9 × 102 Pa s for NC8_700 to 3.76 × 106 Pa s for NC8_732; an increase in elasticity at the level of 1–1000 kPa), and thermal properties of the nanocomposites. A mechanistic study showed that nanohydroxyapatite exhibits a high degree of association with the gel and interferes with its gelation owing to changes in hydrogen bonding interactions between C=?O of polymer chains and P–OH groups of nanohydroxyapatite with water molecules of the gel. A schematic was developed demonstrating changes in bonding interactions among constituent phases with respect to nanohydroxyapatite content emphasizing the importance of material interactions while fabricating multi‐phase nanocomposites for various biomedical applications. Copyright © 2017 John Wiley & Sons, Ltd. 相似文献