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81.
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本文导出了损伤材料的全量理论,导出了全量公式中H的渐近表达式;最后得到损伤材料平面应变条件下的裂纹尖端的应力应变场。 相似文献
83.
We report in this work a fast protocol for protein quantification and for peptide mass mapping that rely on 18O isotopic labeling through the decoupling procedure. It is demonstrated that the purity and source of trypsin do not compromise the labeling degree and efficiency of the decoupled labeling reaction, and that the pH of the labeling reaction is a critical factor to obtain a significant 18O double labeling. We also show that the same calibration curve can be used for MALDI protein quantification during several days maintaining a reasonable accuracy, thus simplifying the handling of the quantification process. In addition we demonstrate that 18O isotopic labeling through the decoupling procedure can be successfully used to elaborate peptide mass maps. BSA was successfully quantified using the same calibration curve in different days and plasma from a freshwater fish, Cyprinus carpio, was used to elaborate the peptide mass maps. 相似文献
84.
Chris Petucci Tom Lloyd Heather A. Harris Xiaochun Zhang Vargheese M. Chennathukuzhi Belew Mekonnen Yanxuan Cai 《Journal of mass spectrometry : JMS》2010,45(1):65-71
A sensitive LC/MS/MS method has been developed by derivatization of 17β‐estradiol (E2) with dansyl chloride to quantitate 17β‐E2 in female rat serum. The use of E2‐d5 minimized interferences from endogenous 17β‐E2 in order to achieve a limit of quantitation (LOQ) of 2.5 pg/ml using 150 µl of female rat serum. The recovery of the dansyl derivative was 95% or greater in quality control samples. The intra and interday assay precision was better than 8.2 and 6.2%, respectively, with accuracies ranging from 97 to 101% in the quality control samples. The assay was used for the quantitation of serum E2 as a biomarker for the estrogen receptor (ER) antagonist activity of small molecule SERMs (selective estrogen receptor modulators) in the female rat brain. The study revealed that a statistically significant upregulation of serum 17β‐E2 occurred for rats dosed with SERMs that are known to penetrate the brain and disrupt the hypothalamic‐pituitary‐ovarian (HPO) axis. Variations in 17β‐E2 in ascending dose studies also correlated with the corresponding trends in CYP17a1 levels, an mRNA biomarker for ovarian hyperstimulation. This biomarker assay has provided a useful screen for medicinal chemistry optimization to produce SERMs that do not interfere with negative feedback of estrogens on the brain and for biological hypothesis testing. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
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The comparison between three classical potentials and density functional theory (DFT) is performed mainly for divacancy and hexavacancy in Si crystal. According to their performances on the formation energies and structural properties (distortion magnitude, relaxation volume and symmetry), the limitations and validities of classical potentials are discussed. It is found that the outward relaxation directions of EDIP and Tersoff (T3) are contrary to the DFT and Stillinger-Weber (SW) directions (inward), which restrict their application in the structural property calculations. Except for the divacancy symmetries, the results of SW are in agreement with the DFT results. Thus, it can be concluded that SW should be the best potential to describe V2 and V6. 相似文献
87.
In this paper, the viability of using a genetic algorithm to find band structure parameters for empirical pseudopotential method (EPM) calculations is demonstrated by applying a genetic algorithm to find the EPM parameters for 4H-SiC. The form of the pseudopotential for 4H-SiC and the 19 form factors found by the genetic algorithm to fit the band structure to experimentally measured indirect energy gap and direct optical gaps are given. In addition, the effective masses for the conduction band minimum are extracted from the calculated band structure. It is shown that the genetic algorithm provides an effective, automated way to find parameters that give reasonably good fits to both the band gaps and the effective masses simultaneously. 相似文献
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To achieve robustness against the outliers or heavy-tailed sampling distribution, we consider an Ivanov regularized empirical risk minimization scheme associated with a modified Huber's loss for nonparametric regression in reproducing kernel Hilbert space. By tuning the scaling and regularization parameters in accordance with the sample size, we develop nonasymptotic concentration results for such an adaptive estimator. Specifically, we establish the best convergence rates for prediction error when the conditional distribution satisfies a weak moment condition. 相似文献