Effect of pulse magnetic field stimulation on calcium channel current

This study aimed to investigate the effect of low frequency and high amplitude pulse magnetic field (PMF) on Calcium ion channel current of cells. Measurements were done on the Human Embryonic Kidney 293 cells (HEK 293), which have only Calcium ion channels functioning. The whole cell current was measured by patch clamp method, with the clamped voltage ramping from −90 mV to +50 mV across the cell membrane. A PMF was generated by a 400-turn coil connected to a pulse current generator. The frequency of the pulse was 7 Hz, the width of the pulse was 3 ms, and the amplitude of the pulse, or the flux density, was ranging from 6 to 25 mT. The results showed that the profile of the whole cell Calcium channel current could be modified by the PMF. With the PMF applied, the phase shifting occurred: the onset of the channel opening took place several mili-seconds earlier than that without the PWF and correspondingly, the whole cell current reached its maximum earlier, and the current returned back to zero earlier as well. When the PWF was stopped, these effects persisted for a period of time, and then the current profile “recovered” to its original appearance. The decrease of the onset time and peak current time could be due to the local electric potential induced by the PWF and the direct interaction between PMF and ion channels/ions. The exact mechanisms of the observed effects of PMF on the cell are still unknown and need to be further studied.     

Intermittency,Moments, and Friction Coefficient during the Subcritical Transition of Channel Flow

The intermittent distribution of localized turbulent structures is a key feature of the subcritical transitions in channel flows, which are studied in this paper with a wind channel and theoretical modeling. Entrance disturbances are introduced by small beads, and localized turbulent patches can be triggered at low Reynolds numbers (Re). High turbulence intensity represents strong ability of perturbation spread, and a maximum turbulence intensity is found for every test case as Re ≥ 950, where the turbulence fraction increases abruptly with Re. Skewness can reflect the velocity defects of localized turbulent patches and is revealed to become negative when Re is as low as about 660. It is shown that the third-order moments of the midplane streamwise velocities have minima, while the corresponding forth-order moments have maxima during the transition. These kinematic extremes and different variation scenarios of the friction coefficient during the transition are explained with an intermittent structure model, where the robust localized turbulent structure is simplified as a turbulence unit, a structure whose statistical properties are only weak functions of the Reynolds number.     

Determination of the best carrier frequency based on the system and environmental parameters in underwater acoustic systems

One of the most challenging features of underwater acoustic (UWA) channel in comparison with its terrestrial radio frequency counterpart is highly frequency-dependent path loss. Thus, utilizing efficient carrier frequencies in UWA systems can considerably reduce the path loss. In this context, this paper presents an approximate formula for determining the best carrier frequency based on both the system and environmental parameters. To achieve this goal, this research first addresses a simple algorithm including general steps for tuning the parameters of Francois and Garrison (FG) formula in the frequency range of 10 to 100 kHz based on the appropriate experimental data which can be acquired from any interest region. Second, for a more accurate modeling of path loss, this paper considers the loss due to the reflections of sound from both the rough surface and bottom of the sea by employing the ray theory. Third, this study presents a general algorithm for modification of the power spectral density (PSD) of ambient noise based on Wenz formula in the frequency range of 10 to 100 kHz and the required experimental measurements which can be simply collected from any interest channel. Moreover, it is mathematically demonstrated that the ambient noise in the frequency range of 10 to 100 kHz, can be generally approximated with a strict sense stationary (SSS) colored normal stochastic process which is ergodic not only in mean and covariance but also in distribution. Finally, an approximate formula for the best carrier frequency is derived by maximizing the sound to noise intensity ratio (SNR). To verify the validity of simplifications and approximations utilized in this study and to assess the performance of our proposed algorithms and formulas, experimental results obtained in the Strait of Hormuz (SoH) are compared with the original, simplified, and modified models under different scenarios.     

基于模糊标签和深度学习的TOF-MRA影像脑动脉瘤自动检测

脑动脉瘤破裂造成的蛛网膜下腔出血致死致残率极高，借助深度学习网络辅助医生实现高效筛查具有重要意义．为提高基于时间飞跃法磁共振血管造影（Time of Flight-Magnetic Resonance Angiography，TOF-MRA）的脑动脉瘤自动检测的精度，本文基于模糊标签方式，提出一种基于变体3D U-Net和双分支通道注意力（Dual-branch Channel Attention，DCA）的深度神经网络DCAU-Net，DCA模块可以自适应地调整通道特征的响应，提高特征提取能力．首先对260例病例的TOF-MRA影像预处理，将数据集分为174例训练集、43例验证集和43例测试集，然后使用处理后的数据训练和验证DCAU-Net，测试集实验结果表明DCAU-Net可以达到90.69%的敏感度，0.83个/例的假阳性计数和0.52的阳性预测值，有望为动脉瘤筛查提供参考．     

Comparative study of classifiers to mitigate intersymbol interference in diffuse indoor optical wireless communication links

The maximum data rate that can be achieved in diffuse indoor optical wireless communication (OWC) is limited due to the effect of intersymbol interference (ISI). The adverse effect of ISI on the system performance can be minimised using a channel equaliser at the receiver. In this study, digital signal detection is formulated as a classification problem and hence a classifier is adopted at the receiver. The bit error performance of classifiers with non-linear decision boundary including a multilayer perceptron (MLP), a support vector machine (SVM), the radial basis function (RBF), and the Bayesian classifier is studied along with traditional equaliser and reported here. The MLP offers the best performance; however there is trade-off between the performance and complexity especially at highly diffuse channel.     

部分植被化矩形河槽紊流时均流速分布分析解

研究了部分植被化矩形河槽紊流的水深平均流速分布．植被被视为不可移动的刚性多孔介质,植被对水流的阻力以多孔介质理论加以考虑,并综合考虑部分植被存在时矩形河槽紊动水流二次流的作用,建立了紊流动量方程．针对恒定均匀流的特点,对动量方程进行了简化,沿水深方向积分并引入参考量,形成无量纲形式的基于多孔介质理论紊动水流控制方程,进而对其求解给出了水深平均纵向时均流速分布的分析解．研究表明,在不同水流条件下的二次流强度系数具有相同的数量级．为验证分析解的正确性,在实验室采用MicoADV测量了部分植被化矩形河槽水流的流速分布．数值解与实验资料和日本学者的相关实验资料的对比表明,该方法可以准确预测部分植被化矩形河槽紊流水流的水深平均流速分布．     

Superior material qualities and transport properties of InGaN channel heterostructure grown by pulsed metal organic chemical vapor deposition

Pulsed metal organic chemical vapor deposition is introduced into the growth of In Ga N channel heterostructure for improving material qualities and transport properties. High-resolution transmission electron microscopy imaging shows the phase separation free In Ga N channel with smooth and abrupt interface. A very high two-dimensional electron gas density of approximately 1.85 × 1013cm-2is obtained due to the superior carrier confinement. In addition, the Hall mobility reaches 967 cm2/V·s, owing to the suppression of interface roughness scattering. Furthermore, temperature-dependent Hall measurement results show that In Ga N channel heterostructure possesses a steady two-dimensional electron gas density over the tested temperature range, and has superior transport properties at elevated temperatures compared with the traditional Ga N channel heterostructure. The gratifying results imply that In Ga N channel heterostructure grown by pulsed metal organic chemical vapor deposition is a promising candidate for microwave power devices.