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21.
Synthetic Multivalent Glycopeptide‐Lipopeptide Antitumor Vaccines: Impact of the Cluster Effect on the Killing of Tumor Cells 下载免费PDF全文
Dr. Hui Cai Zhan‐Yi Sun Mei‐Sha Chen Prof. Dr. Yu‐Fen Zhao Prof. Dr. Horst Kunz Prof. Dr. Yan‐Mei Li 《Angewandte Chemie (International ed. in English)》2014,53(6):1699-1703
Multivalent synthetic vaccines were obtained by solid‐phase synthesis of tumor‐associated MUC1 glycopeptide antigens and their coupling to a Pam3Cys lipopeptide through click reactions. These vaccines elicited immune responses in mice without the use of any external adjuvant. The vaccine containing four copies of a MUC1 sialyl‐TN antigen showed a significant cluster effect. It induced in mice prevailing IgG2a antibodies, which bind to MCF‐7 breast tumor cells and initiate the killing of these tumor cells by activation of the complement‐dependent cytotoxicity complex. 相似文献
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某类多叶解析函数的性质 总被引:1,自引:0,他引:1
设A(p)(p是指数,p≥1)表示在单位圆盘E内形如f(z)=z^p ap 1z^p 1…的解析函数族。本文引进了新的函数子类Hσ(p,α),找出了Hσ(p,α)闭凸包的极值点并给出精确的系数估计,还讨论了Hσ(p,α)其它一些有趣的性质。 相似文献
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《Macromolecular bioscience》2017,17(4)
Multivalent aptamer–siRNA conjugates containing multiple mucin‐1 aptamers and BCL2‐specific siRNA are synthesized, and doxorubicin, an anthracycline anticancer drug, is loaded into these conjugates through intercalation with nucleic acids. These doxorubicin‐incorporated multivalent aptamer–siRNA conjugates are transfected to mucin‐1 overexpressing MCF‐7 breast cancer cells and their multidrug‐resistant cell lines. Doxorubicin‐incorporated multivalent aptamer–siRNA conjugates exert promising anticancer effects, such as activation of caspase‐3/7 and decrease of cell viability, on multidrug‐resistant cancer cells because of their high intracellular uptake efficiency. Thus, this delivery system is an efficient tool for combination oncotherapy with chemotherapeutics and nucleic acid drugs to overcome multidrug resistance.
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Metal–Organic Frameworks (MOFs) as Multivalent Materials: Size Control and Surface Functionalization by Monovalent Capping Ligands 下载免费PDF全文
Timon Rijnaarts Raquel Mejia‐Ariza Richard J. M. Egberink Dr. Wies van Roosmalen Prof. Dr. Jurriaan Huskens 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(29):10296-10301
Control over particle size and composition are pivotal to tune the properties of metal organic frameworks (MOFs), for example, for biomedical applications. Particle‐size control and functionalization of MIL‐88A were achieved by using stoichiometric replacement of a small fraction of the divalent fumarate by monovalent capping ligands. A fluorine‐capping ligand was used to quantify the surface coverage of capping ligand at the surface of MIL‐88A. Size control at the nanoscale was achieved by using a monovalent carboxylic acid‐functionalized poly(ethylene glycol) (PEG‐COOH) ligand at different concentrations. Finally, a biotin–carboxylic acid capping ligand was used to functionalize MIL‐88A to bind fluorescently labeled streptavidin as an example towards bioapplications. 相似文献
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Localized Template‐Driven Functionalization of Nanoparticles by Dynamic Combinatorial Chemistry 下载免费PDF全文
Piotr Nowak Dr. Vittorio Saggiomo Dr. Fatemeh Salehian Mathieu Colomb‐Delsuc Dr. Yang Han Prof. Dr. Sijbren Otto 《Angewandte Chemie (International ed. in English)》2015,54(14):4192-4197
We have developed a method for the localized functionalization of gold nanoparticles using imine‐based dynamic combinatorial chemistry. By using DNA templates, amines were grafted on the aldehyde‐functionalized nanoparticles only if and where the nanoparticles interacted with the template molecules. Functionalization of the nanoparticles was controlled solely by the DNA template; only amines capable of interacting with DNA were bound to the surface. Interestingly, even though our libraries contained only a handful of simple amines, the DNA sequence influenced their attachment to the surface. Our method opens up new opportunities for the synthesis of multivalent, nanoparticle‐based receptors for biomacromolecules. 相似文献
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Multivalent Polymer Nanocomplex Targeting Endosomal Receptor of Immune Cells for Enhanced Antitumor and Systemic Memory Response 下载免费PDF全文
Sun‐Young Kim Min Beom Heo Dr. Geum‐Sook Hwang Youngae Jung Dr. Do Yeol Choi Prof. Dr. Yeong‐Min Park Prof. Dr. Yong Taik Lim 《Angewandte Chemie (International ed. in English)》2015,54(28):8139-8143
We have designed and synthesized linear polymer‐based nanoconjugates and nanocomplexes bearing multivalent immunostimulatory ligands and also demonstrated that the synthetic multivalent nanocomplexes led to an enhanced stimulation of immune cells in vitro and antitumor and systemic immune memory response in vivo. We have developed hyaluronic acid (HA)‐based multivalent nanoconjugates and nanocomplexes for enhanced immunostimulation through the combination of multivalent immune adjuvants with CpG ODNs (as a TLR9 ligand) and cationic poly(L ‐lysine) (PLL; for the enhancement of cellular uptake). The multivalent HA‐CpG nanoconjugate efficiently stimulated the antigen‐presenting cells and the multivalent PLL/HA‐CpG nanocomplex also led to an enhanced cellular uptake as well as continuous stimulation of endosomal TLR9. The mice vaccinated with dendritic cells treated with the multivalent nanocomplex exhibited tumor growth inhibition as well as a strong antitumor memory response. 相似文献
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Functionalized polyrotaxanes are utilized to investigate the relation to multivalent interactions between the mannose moiety and Con A immobilized surfaces. According to the results of SPR spectroscopy, the mannose-conjugated polyrotaxanes show a higher response than any other mannose conjugate on both surfaces of high- and low-density Con A. Moreover, the results of the FRET analysis suggest that the mobility of α-cyclodextrins in the polyrotaxane more efficiently contributes to their binding interactions in a multivalent manner. This well-defined polyrotaxane system provides control over ligand density, ligand mobility, and gives an efficient response to the biological interaction receptor, which has not been easy to achieve in covalently bound polymeric systems. 相似文献
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It is well-known that the classes of starlike, convex and close-to-convex univalent functions are closed under convolution with convex functions. In this paper, closure properties under convolution of general classes of meromorphic p-valent functions that are either starlike, convex or close-to-convex with respect to n-ply symmetric, conjugate and symmetric conjugate points are investigated. 相似文献
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Structurally well defined di-, tri- and tetra-valent cluster galactosides were synthesized in a convenient way.Oligo-glutamic acids were assembled as scaffolds. The presence of amine groups in these three ligands is expected to couple with drugs or genes for delivery. The binding affinities of these cluster galactoses to liver cells were determined by in vitro binding studies. Among them, the tetravalent cluster galactose (19) showed the highest affinity to liver cell. It is therefore a promising targeting device for the specific delivery of drugs or genes to parenchymal liver cells. 相似文献