基于残余力向量的桁架梁损伤识别研究

定义残余力向量为结构的损伤指标,给出了根据结构特征值方程详细推导残余力向量的理论过程.并以简支桁架梁为研究对象,利用残余力向量进行桁架梁的局部损伤识别,成功识别出桁架梁的单一和多处局部损伤;同时考虑实际测量中存在噪声影响,引入了损伤定位指数,分析了噪声对损伤识别精度的影响.理论分析和数值仿真结果表明,残余力向量能有效识别桁架梁的局部中小损伤,且有较好的抗噪性.     

电机温度时滞耦合系统自抗扰控制仿真研究

电机温度过高会造成绝缘性能老化,电机安全性能下降。电机控制系统是典型的非线性系统,电机温度也因此具有时滞性和耦合性的特点,难以建立准确的数学模型。传统的方法对电机温度的控制精度较差,从而导致电机温度失控。为此,提出基于BP神经网络自抗扰控制算法的电机时滞耦合关系下温度控制方法。将BP神经网络与PID控制方法相结合建立电机温度网络自抗扰控制器模型,利用梯度下降法修正电机温度控制器模型的权值系数,从而实现了BP神经网络自抗扰控制器参数的实时调整。实验结果表明,利用BP神经网络自抗扰算法进行电机时滞耦合关系下温度调整,能够有效提高控制的精确度,缩短了控制过程中的时间延时。     

Quadruplex Genotyping of TLR-8 Polymorphisms in a Single Reaction

Toll-like Receptor 8 (TLR8) plays an important role in the innate immune defense against various pathogens. The TLR8 genetic variation affects the course of infections with agents such as HIV, HCV, and mycobacteria. To assess the influence of single nucleotide polymorphisms (SNPs) large cohorts need to be studied; thus, rapid and cost-efficient protocols for high-throughput TLR8 genotyping are needed. We designed a single-tube assay for genotyping four SNPs located to the major coding exon of TLR8 using the LightCycler 480 system. The new method is accurate, fast, low-priced, and can be applied for fully automated high-throughput genotyping of TLR8 SNPs.     

具有高阶代数免疫的弹性函数

构造了一类具有一阶弹性的函数.该函数是级联4个具有一对拟线性变量的子函数得到的.给出了新函数代数次数不增加的充分必要条件,代数免疫阶不增加的必要条件.选取的初始函数不满足代数次数和代数免疫不增加的必要条件,那么得到函数和初始函数相比,代数免疫至少增加1阶,代数次数增加1次,并且具有1阶弹性.     

非理想性对B-Z反应体系时间自组织的影响

从理论和实验上研究了非理想性对B-Z反应体系时间自组织行为的影响,重点考察了加入惰性电解质对B-Z反应体系振荡周期的影响,按照Oregonator模型,通过小寄生参数法动力学理论分析表明,非理想性对B-Z反应体系振荡周期的影响体现在振荡周期与铈离子的活度系数成反比,而且惰性电解质的加入使得振荡周期进一步加长.通过一系列实验观测,原则上得到了与理论分析一致的结论.     

Dendritic Mesoporous Silica Nanoparticle Adjuvants Modified with Binuclear Aluminum Complex: Coordination Chemistry Dictates Adjuvanticity

Aluminum-containing adjuvants used in vaccine formulations suffer from low cellular immunity, severe aggregation, and accumulation in the brain. Conventional aluminosilicates widely used in the chemical industry focus mainly on acidic sites for catalytic applications, but they are rarely used as adjuvants. Reported here is an innovative “ligand-assisted steric hindrance” strategy to create a high density of six-coordinate ^VIAl−OH groups with basicity on dendritic mesoporous silica nanoparticles as new nanoadjuvants. Compared to four-coordinate ^IVAl-modified counterparts, ^VIAl−OH-rich aluminosilicate nanoadjuvants enhance cellular delivery of antigens and provoke stronger cellular immunity. Moreover, the aluminum accumulation in the brain is more reduced than that with a commercial adjuvant. These results show that coordination chemistry can be used to control the adjuvanticity, providing new understanding in the development of next-generation vaccine adjuvants.     

Temporary threshold shift in human subject exposed to noise

Using an audiometer,the effect of the noise level upon temporarythreshold shift(TTS)for five trained normal subjects(left ear only)was studied.The measurements were carried out after 6 min exposure(in third octave band)for different sound pressure levels ranging between 75-105 dB at three test fre-quencies 2,3,and 4 kHz.The results indicated that at exposure to noise of soundpressure level(SPL)above 85 dB,TTS increases linearly with ths SPL for all thetest frequencies.The work had extended to study the recovery curves for the sameears.The results indicated that the reduction in TTS on doubling the recoverytimes,for the two sound pressure levels 95 dB and 105 dB,occurs at a rate of near-ly 3 dB.The comparison of the recovery curve at 3 kHz with that calculated usingWard's general equation for recovery was made.Finally,to study the values ofTTS produced by exposure to certain noise at different test frequencies,distribu-tion curves for two recovery times were plotted representing TTS values,for anexposure     

PURIFICATION,CHARACTERIZATION AND STRUCTURE OF CM_2Ph_1,AN ANTIBACTERIAL PEPTIDE FROM Bombyx mori

Using HPLC we purified an antibacterial peptide named CM_2Ph_1 from the hemolymph ofpupae of silkworm (Bombyx mori) immunized with polyI:C. Amino acid composition analysisshowed that CM_2Ph_1 contained 16 kinds of amino acids. Its primary structure determined bythe automatic Edman degradation method is GNFFKDLEKMGQRVRDAVISAAPAVDTLAKA-KALGQ. Its C-terminal residue was assumed to be Gln with a blocking α-carboxylamide bycarboxypeptidases analysis. The purified CM_2Ph_1 was found to have inhibition effects invarying degrees on several bacterial strains. At a concentration of 0.35 μmol/L, CM_2Ph_1could inhibit the growth of 50% E. coli D31 strain. Some other antibacterial peptides were compared with CM_2Ph_1 in respect to their struc-tures and functions. Their homology was also discussed in this paper.