小分子药物在半结晶乙烯-醋酸乙烯酯共聚物(EVA)中的扩散机理:自由体积理论

半结晶乙烯 醋酸乙烯酯共聚物 (ＥＶＡ)是扩散控制药物释放体系中使用最多的聚合物 ,它具有生物相容性好 ,加工成型方便 ,机械性能好及理化性质稳定等特点 ,是经ＦＤＡ批准的可用于人体的高分子材料之一 ,已广泛应用于宫内给药体系 ,眼用给药体系 ,透皮给药体系及植入给药体系等 ,并且已有商品化的以ＥＶＡ为基质的药物控制释放系统[1～ 3 ] ,然而对于小分子药物在半结晶ＥＶＡ共聚物中的扩散机理却少见报道 .本文将自由体积理论应用于ＥＶＡ基质型药物扩散控制释药体系 ,阐明了小分子药物在半结晶ＥＶＡ聚合物中的扩散系数随共聚物组成的…     

推广的半绝对离差和动态投资组合选择

在标准的Black－Scholes型金融市场下，建立了以推广的半绝对离差（Extended Semi－Absolute Deviation；ESAD）度量风险的动态均值-ESAD投资组合选择模型，研究了模型的求解方法，得到了最优投资组合策略和均值-ESAD有效前沿的解析表达式．同时，与动态均值-方差模型作了比较分析．最后，结合实例说明了模型的求解方法．     

某半合成青霉素制药废水的水质指纹特性

近年来,地表水中时有抗生素检出,且浓度较高,因此加强抗生素废水的监管势在必行。三维荧光技术快速、简便且灵敏度高,可以反映有机物组成,其光谱被称为水质指纹。选取某典型半合成青霉素制药废水进行水质指纹特性研究。该废水共有4个主要水纹峰,分别位于激发波长/发射波长为360/445,255/445,275/305和230/300 nm附近。在一定浓度范围内,各峰强度与污染物浓度呈现良好的线性关系。该废水的两个峰275/305和230/300 nm可能源于产品中间体左旋对羟基苯甘氨酸邓钾盐、产品阿莫西林和水解产物左旋对羟基苯甘氨酸等。pH对水质指纹有明显影响,这显示出某些荧光污染物可能具有酸碱基团。水质指纹能够用于该种抗生素制药废水的监测。     

基于LabVIEW与Multisim的火控系统半实物联合仿真方法

针对当前装甲装备火控系统电路组成与功能特点,对火控系统维修保养过程中的故障诊断方法与测试需求进行了研究,提出了一种火控系统半实物联合仿真方法,介绍了该仿真建模方法的设计思路与实现方法。该方法可充分发挥LabVIEW和Multisim软件的优势,通过半实物联合仿真的方法,以仿真模型代替部分或者全部火控系统部组件,能够很好地实现火控系统不同级别的电路功能模拟、故障复现,快速完成故障诊断分析,解决了当前装甲装备火控系统维修诊断设备通用性差、规范化程度低、开放性差,难以真实的模拟系统级、部件级功能、故障注入和故障检测等问题,为装甲装备火控系统故障诊断与测试设备开发提供了有效平台,为基层部队开展维修训练和维护保障提供了有效途径。     

关于子群的两种广义正规性的注记

群 G 的一个子群 H 称为在 G 中具有半覆盖远离性,如果存在 G 的一个主群列1=G_0＜ G_1＜…＜G_1=G,使得对每一 i=1,…,l 或者 H 覆盖 G_j/G_(j-1)或者 H 远离 G_j/G_(j-1)．本文证明了予群的半覆盖远离性是子群 C-正规性和子群的覆盖远离性之推广．进一步应用极大子群和 Sylow 子群给出了有限群为可解群的一些特征．     

半参数回归模型在空气质量指数分析和预测中的应用

根据2013年6月到2013年8月年武汉市一个检测点有关空气质量指数的数据,运用半参数回归模型对空气质量指数进行拟合,得到了空气质量指数与各有关指标的关系．实证分析表明,半参数回归模型拟合比较准确,预测结果也比较理想．     

On Semi Cover-Avoiding Maximal Subgroups of Sylow Subgroups of Finite Groups

A subgroup H of a finite group G is called to have semi cover-avoiding property in G if there is a normal series of G such that H either covers or avoids every normal factor of the series. In this article we get some new results under the assumption that every maximal subgroup of Sylow subgroups of a suited subgroup of G has semi cover-avoiding property in G. We state our results in the broader context of formation theory.     

Synthesis of novel 1,4-disubstituted-1,2,3-triazole semi synthetic analogues of forskolin by click reaction

New 1,4-disubstituted-1,2,3-triazole analogues of forskolin (5a-g, 6a-g) have been prepared by regioselective propargylation at 1-position followed by Cu(I) catalysed cycloaddition of different alkyl azides under the click reaction conditions. An interesting acyl shift in the base catalysed propargylation afforded a new series of 1,4-disubstituted-1,2,3-triazole analogues of forskolin (6a-g). These analogues have potential selective therapeutic applications as antihypertensive, antiglaucoma, antiasthma and antiobesity agents.     

A comparison between neural network method and semi empirical equations to predict the solubility of different compounds in supercritical carbon dioxide

Accuracy of seven semi empirical equations for the estimation of solubility of 30 different compounds in supercritical carbon dioxide has been compared with a new neural network method. To base this comparison on a fair basis, a unique set of experimental data was used for both optimization of semi empirical equations’ parameters and training, validation and testing of neural network. Results showed that neural network method with an average relative deviation of about 5.3% was more accurate than the best semi empirical equation with an average relative deviation of about 15.96% for same compounds. It was also found that the average relative deviation of semi empirical equations varies sharply among different compounds, while this quantity is less dependent on material type for neural network method.     

Synchronization of spatiotemporal semiconductor lasers and its application in color image encryption

Optical chaos is a topic of current research characterized by high-dimensional nonlinearity which is attributed to the delay-induced dynamics, high bandwidth and easy modular implementation of optical feedback. In light of these facts, which add enough confusion and diffusion properties for secure communications, we explore the synchronization phenomena in spatiotemporal semiconductor laser systems. The novel system is used in a two-phase colored image encryption process. The high-dimensional chaotic attractor generated by the system produces a completely randomized chaotic time series, which is ideal in the secure encoding of messages. The scheme thus illustrated is a two-phase encryption method, which provides sufficiently high confusion and diffusion properties of chaotic cryptosystem employed with unique data sets of processed chaotic sequences. In this novel method of cryptography, the chaotic phase masks are represented as images using the chaotic sequences as the elements of the image. The scheme drastically permutes the positions of the picture elements. The next additional layer of security further alters the statistical information of the original image to a great extent along the three-color planes. The intermediate results during encryption demonstrate the infeasibility for an unauthorized user to decipher the cipher image. Exhaustive statistical tests conducted validate that the scheme is robust against noise and resistant to common attacks due to the double shield of encryption and the infinite dimensionality of the relevant system of partial differential equations.