Secokaraconitine, A New Diterpenoid Alkaloid from Aconitum karacolicum

The known diterpenoid alkaloids karacoline, karakanine, songorine, napelline, 12-acetylnapelline, cammaconine, and a new 7,17-secoalkaloid of the lycoctonine type, secokaraconitine, were isolated from tubers of Aconitum karacolicum. An x-ray structure analysis of the new alkaloid was performed.     

Total synthesis of (±)-cyclooroidin

The first total synthesis of (±)-cyclooroidin, a member of the pyrrole-imidazole alkaloid family recently isolated from the sponge Agelas oroides in optically pure form, is described. The synthesis was achieved in nine linear steps, with an overall yield of 10%. Key step was a Wolff bromoketone synthesis performed on the intermediate longamide B.     

16-Demethoxymethyllycaconitine,a new norditerpenoid alkaloid from Delphinium cuneatum

A new norditerpenoid alkaloid has been isolated from the roots of Delphinium cuneatum. On the basis of ¹H, ¹³C NMR, IR, and mass spectra, the structure of the alkaloid was established as 1,6,14-trimethoxy-7,8-dihydroxy-18-(2-methyl)succinylanthranoyloxyaconane (16-demethoxymethyllycaconitine). The roots of Delphinium cuneatum also contain the known alkaloid methyllycaconitine and N,N"-di(methoxycarbonyl)-3,4-diaminotoluene.     

Macrodasine A, a novel macroline derivative incorporating fused spirocyclic tetrahydrofuran rings containing a spiroacetal moiety

A novel indole alkaloid, viz., macrodasine A, incorporating fused spirocyclic tetrahydrofuran rings onto a macroline-like moiety, was obtained from a Malayan Alstonia species. The structure, which is also notable for the presence of an unprecedented spiroacetal moiety in an indole alkaloid, was established by spectroscopic analysis.     

基于Cz-DPP不对称D-A结构新型有机小分子光伏材料的合成与性质

本文设计合成了一系列以咔唑(CZ)和吡咯并吡咯二酮(DPP)为基本结构单元的D-A结构的新型小分子材料,并对其进行了一系列的性能表征.合成的材料以咔唑作为给电子单元,吡咯并吡咯二酮作为吸电子单元,采用三键作为π桥,并引入4-氟苯基、4-氰基苯基和4-甲氧基苯基作为末端取代基团对材料进行修饰.其中材料CZBTDPPF和CZBTDPPO因分别具有1.85和1.79 eV的较窄带隙而分别获得了相对较高的的光电转化效率(1.97%和1.91%).由此可见,引入4-氟苯基和4-甲氧基苯基作为末端取代基团对于延长材料共轭结构、拓宽材料吸收从而实现材料光伏性能的提升具有重要的作用.     

The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity

The polysaccharide (PSH) extracts from the edible mushroom species Coprinus comatus and Coprinellus truncorum were screened in liquid for their acetylcholinesterase inhibitory (AChE) activity. Both extracts were found to display inhibition of the aforementioned enzyme reaching similar IC₅₀ values of 0.62 ± 0.07 and 0.61 ± 0.03 mg/mL, respectively. According to the means of FTIR spectroscopy, these PSH extracts mostly contained β-glucans. However, the presence of some proteins and polyphenolics as minor ingredients were also detected. Compared with existing literature data for anti-AChE activity of the sugar samples, the findings within this study may be treated as a profound bioactivity. Consequently, this study puts some light on the possible use of the screened macrofungi in the palliative treatment of Alzheimer’s disease.     

Analysis of drugs by AAS via formation of ion pairs

A new procedure for determining nitrogenated bases by forming ion pairs with Fe(SCN)6^3– is studied. The method consists of extracting the ion pair formed by a nitrogenated base and the inorganic complex Fe(SCN)6^3– into an organic phase, and measuring the iron in the organic phase by AAS at 248.3 nm. The optimal experimental conditions for determining amylocaine, avacan, bromhexine, diphenhydramine and papaverine are studied. The organic phase used is 1,2-dichloroethane. The standard deviation of the method varies between 10^–1 and 10^–2. The interferences produced by various substances are studied.     

Isolation of lappaconitine from Aconitum septentrionale roots by adsorption

Extracts of Aconitum septentrionale Koelle roots obtained using chloroform, isopropanol, and ethanol were purified using chloroform and basic γ-Al₂O₃. Ballast materials were selectively adsorbed by γ-Al₂O₃, increasing the mass fraction of lappaconitine in the extract. The ethanol extract was purified most. The degree of lappaconitine extraction by chloroform was unaffected by the presence of γ-Al₂O₃. However, the mass fraction in the extract and lappaconitine extraction from Aconitum septentrionale were increased more than twice. __________ Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 274–276, May–June, 2006.     

Biomimetic oxidative transformations of pericine: partial synthesis of apparicine and valparicine, a new pentacyclic indole alkaloid from Kopsia

A new pentacyclic indole alkaloid of the pericine-type, valparicine, representing the first member of this sub-group, was obtained from a Malayan Kopsia species and the structure was established by spectroscopic analysis. A partial synthesis of valparicine and apparicine from pericine was carried out via the Potier-Polonovski reaction and the biogenetic implications are discussed.     

Enaminone‐Based Synthesis of Dipodazine Derivatives

A series of racemic dipodazine analogues 9 were prepared in 22–80% yield from (3Z,6RS)‐3‐[(dimethylamino)methylidene]‐6‐methyl‐1‐(phenylmethyl)piperazine‐2,5‐dione ( 7 ) (Scheme 1), which was prepared in four steps from (RS)‐alanine methyl ester hydrochloride. The preparation of nonracemic 7 from (S)‐alanine methyl ester hydrochloride failed, since the introduction of the enamino functionality at position 3 of the precursor 6 was accompanied by almost complete racemization.