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41.
Holm R Schönbeck C Askjær S Jensen H Westh P Østergaard J 《Journal of separation science》2011,34(22):3221-3230
The interaction of the bile salts taurocholate, taurodeoxycholate, taurochenodeoxycholate, glycocholate, glycodeoxycholate, and glycochenodeoxycholate present in man, dog, and rat with α-cyclodextrin and 2-hydroxypropyl-α-cyclodextrin was investigated by mobility shift affinity capillary electrophoresis. The cyclodextrins are applied as excipients for solubilisation of drug substances with poor aqueous solubility. Accurate determination of stability constants is challenging for weak analyte-ligand interactions such as the conjugated bile salt α-cyclodextrin interactions. A new approach for correction of medium effects due to the high additive concentrations in the background electrolyte was introduced. The use of prostaglandin A(1) as an interacting marker molecule offered a more satisfactory approach for correction than the commonly employed methods based on viscosity or current ratios. The interacting marker was chosen over a non-interacting marker to avoid the difficult validation of the non-interacting properties. The investigated bile salts all interacted with α-cyclodextrin and 2-hydroxypropyl-α-cyclodextrin. Stability constants ranging from 14 to 95 M(-1) were obtained with slightly higher affinities toward the substituted cyclodextrin. Molecular modelling demonstrated that the interaction between the two species involves the side chain of the bile salt. All together, these results indicate minor bile salt-mediated displacement of substances from α-cyclodextrin complexes in the small intestine. 相似文献
42.
The effect of the counterpoise correction on the geometries, stabilization energies, and vibrational harmonic frequencies of some hydrogen- and halogen-bonded systems (B?=?CH3CN,?HCN,?NH3,?N2,?CO,?H2O,?H2S,?PH3;?HX?=?HF,?HCl,?HBr,?HCN,?HCF3; XY?=?Br2,?BrCl,?BrF,?Cl2,?ClF,?F2) has been analysed at the MP2 level of theory using the popular 6-311++G(d,p) basis set. The optimized B?···?H and B?···?X bond lengths increase with counterpoise (CP) correction. In some cases standard values and in other cases CP-corrected values are close to experimental data. The absolute values of complexation energies of CP-corrected structures are higher than standard by inclusion of BSSE correction. The effect of CP correction on intermolecular bond lengths and complexation energies of B?···?XY series are usually higher than B?···?HX. Also, this effect is higher for H2S and PH3 groups. The CP correction changes the vibrational harmonic frequencies by 0–100%. The changes are frequently lower than 20% for frequencies higher than 300?cm?1. 相似文献
43.
The title compound1 is found to be protonated corresponding topK
a
's of 2.5 and 0.5, thereby being two orders of magnitude less basic than bilatrienes-abc. Its deprotonation (pK
a
=17.1) is found to be less easy than in case of the bilatrienes.1 is shown to exhibit a very pronounced reactivity for nucleophiles at the methine positions 10 and 15—a thiole adduct and the 10,15-dihydroderivative of1 are isolated and characterised. In contrast to the bilatrienes the adduct formation is irreversible. Accordingly, no diastereomers at exocyclic double bonds could be produced photochemically. Complexation of the lactam oxygens is achieved in case ofLewis acids (eg. AlCl3), chelation after addition of a proton acceptor is observed in a few cases only (Zn++, Hg++, In+++).
Herrn Prof. Dr.K. Kratzl zum 70. Geburtstag gewidmet. 相似文献
44.
A new porphyrin appended with four crown ether units at meso-positions via an acetylene bridge was synthesized and structurally characterized, and its complexation with a variety of metal and diammonium cations was investigated. 相似文献
45.
Fabrice P. L. Andrieux Colin Boxall Robin J. Taylor 《Journal of solution chemistry》2008,37(11):1511-1527
Studies of the thermodynamics of formation of the acetohydroxamatoiron(III) complexes were carried out in acidic media at
temperatures ranging from 293 to 323 K. Through the isolation of the unique UV–visible spectra of all three complexes, it
was possible to determine their formation constants and deduce enthalpies and entropies of formation as well as their molar
absorptivities. The enthalpies of formation of the mono-, bis- and trisacetohydroxamatoiron(III) complexes were found to be
−56.4, −17.09 and +19.74 kJ⋅mol−1, respectively. Following the determination of the enthalpy and entropy of formation of these complexes, speciation diagrams
were calculated for the complexes at temperatures ranging from 293 to 323 K. 相似文献
46.
γ-环糊精与溴甲酚绿的包合作用 总被引:1,自引:1,他引:0
采用紫外-可见分光光度法和等摩尔连续变化法研究了γ-环糊精与溴甲酚绿的包合作用, 确定了包合物形成的化学计量比为1∶2; 采用热力学方法分析了温度与包合常数之间的关系, 计算了包合过程的焓变、熵变及自由能变化分别为-39.988 kJ/mol, 86.400 J/(K·mol)和-14.245 kJ/mol, 这表明疏水作用力为主要驱动力; 采用核磁共振、分子模拟和红外光谱法对包合物进行了研究, 确定了包合物的形成, 分析认为这可能是基团进入γ-环糊精腔内导致增色效应. 相似文献
47.
Natrayasamy Viswanathan 《Journal of fluorine chemistry》2008,129(7):645-653
Indion FR 10 is a commercially available ion exchange resin with sulphonic acid functionality named as H+ form, has appreciable defluoridation capacity (DC). It has been chemically modified to La3+, Fe3+, Ce3+ and Zr4+ forms by incorporating respective metal ions into the resin in order to know their fluoride selectivity by measuring the DC of the respective resin. The maximum DC of these chemically modified ion exchange resins namely La3+, Fe3+, Ce3+ and Zr4+ forms were found to be 469.7, 467.5, 456.3 and 470.9 mg F−/kg respectively suggests their higher selectivity towards fluoride than H+ form which has the DC of only 275 mg F−/kg at 11 mg/L initial fluoride concentration. The higher DC of the modified resins was explained by electrostatic adsorption and complexation whereas H+ form retains fluoride by hydrogen bond. The functional groups present in the sorbents were identified by FTIR and the existence of fluoride onto the resins was confirmed by EDAX analysis. The experimental data was fitted with both Freundlich and Langmuir isotherms. Thermodynamic parameters such as ΔG°, ΔH° and ΔS° indicate that the nature of sorption is spontaneous and endothermic. The applicability of reaction-based and diffusion-based kinetic models was investigated. A field trial was carried out with fluoride water collected from a nearby fluoride-endemic village to test the suitability of these sorbents at field conditions. 相似文献
48.
Lanthanide metal–organic frameworks have been receiving special attention for the last decade. The use of polydentate organic ligands has allowed the construction of interesting network topologies with many potential applications, based on the special characteristics of the 4f electrons. In this paper, the structural and thermodynamic properties of Ln(III) complexes with oxydiacetate, iminodiacetate, and nitrilotriacetate are critically reviewed. The presence of ligands able to act as a bridge promotes the formation of Ln–M polynuclear complexes with fascinating 3D structures, whose study is also included. Equilibrium data of these systems in aqueous solution have been collected, showing the relationship between the composition of the species in solution and the nuclearity in the solid state. 相似文献
49.
50.
Calix[4]arenes with substituents at three of the four OH groups of the lower rim have been synthesized to investigate their properties as ionophores for Na+ and K+ metal ions. Crystal structures of these trisubstituted compounds revealed that the calixarene moiety has adopted a partial cone conformation, however the precise shape of the molecule, and intra- and intermolecular interactions, are significantly different due to variations of the substituents. Compound L2 encapsulated an acetonitrile molecule in the cavity of the calix moiety, held by C–H?π interactions. In the case of L3, the 2-(2-chloroethoxy)-ethanol substituent is involved in strong intramolecular C–H?π interactions with the centroid of the phenyl rings of the calix, bringing the 2-(2-chloroethoxy)-ethanol moiety inward the calix cone, which prevented the entry of any solvent molecule into the cavity. The complexation properties of L2–L4 with Na+ and K+ ions have been investigated in chloroform–methanol mixture by 1H NMR and an attempt has been made to isolate these complexes in the solid state. Complexation studies reveal that only L3 forms a complex selectively with K+, involving 2-(2-chloroethoxy)-ethanol as a coordinating moiety. The association constant (1.4 × 105 M−1) of the complex has also been determined. 相似文献