同步辐射显微红外光谱研究6-OHDA诱导帕金森病细胞模型

神经毒素6-hydroxydopamine (6-OHDA)处理的人神经瘤母细胞系SH-SY5Y是一种经典的帕金森病细胞模型。利用同步辐射红外显微光谱研究6-OHDA处理的SH-SY5Y细胞系的生物化学成分。与正常细胞相比较,所含磷脂的平均饱和水平显著提高,蛋白质的二级结构发生显著变化,其中的β-sheet的比例明显增高,核酸的含量明显下降,提示神经毒素6-OHDA对细胞造成了严重的氧化损伤。同步辐射红外显微光谱能够精确有效的检测到细胞生化成分的改变,从而对细胞的病理损伤进行评估。     

In situ Analysis of Na and K in a Laminar Premixed Flame by Laser-induced Breakdown Spectroscopy

Laser-induced breakdown spectroscopy（LIBS） was used to in situ monitor the concentration of alkali elements in combustion environments. Particular efforts were made to optimize the temporally resolved spectra of Na and K elements. Calibration curves were constructed by relating the intensities of the specific lines to the corres- ponding elemental concentrations. The detection limits of Na and K elements were found to be temperature- dependent. The results indicate that LIBS can be a powerful tool for in situ monitoring Na and K concentrations in combustion environments.     

Collective Excitations of Low Dimensional Trapped Bose-Condensed Gas

In this paper, we investigate excited characteristic of the weakly interacting quasi-one-dimensional (1D) and quasi-two-dimensional (2D) Bose-Einstein condensation (BEC) in harmonic potential trap. The energy spectrum and the analytical expression of the sound velocity are obtained and analyzed. Compared with 3-Dimensional homogeneous Bose-condensed gas occasion, the sound velocity of 2D Bose-Einstein condensation in harmonic potential trap is smaller.     

Shocklets in compressible flows

The mechanism of shocklets is studied theoretically and numerically for the stationary fluid, uniform compressible flow, and boundary layer flow. The conditions that trigger shock waves for sound wave, weak discontinuity, and Tollmien-Schlichting （T-S） wave in compressible flows are investigated. The relations between the three types of waves and shocklets are further analyzed and discussed. Different stages of the shocklet formation process are simulated. The results show that the three waves in compressible flows will transfer to shocklets only when the initial disturbance amplitudes are greater than the certain threshold values. In compressible boundary layers, the shocklets evolved from T-S wave exist only in a finite region near the surface instead of the whole wavefront.     

Series solutions of annular axisymmetric stagnation flow and heat transfer on moving cylinder

The steady, laminar, incompressible flow and heat transfer of a viscous fluid between two circular cylinders for two different types of thermal boundary conditions are investigated. The governing Navier-Stokes and thermal equations of the flow are reduced to a nonlinear system of ordinary differential equations. The equations are solved analyt- ically using the homotopy analysis method （HAM）. Convergence of the HAM solutions is discussed in detail. These solutions are then compared with recently obtained numericM and perturbative solutions. Plots of the velocity and temperature profiles are provided for various values of the relevant parameters.     

MODELING AND DYNAMICS ANALYSIS OF SHELLS OF REVOLUTION BY PARTIALLY ACTIVE CONSTRAINED LAYER DAMPING TREATMENT

A new model for a smart shell of revolution treated with active constrained layer damping （ACLD） is developed, and the damping effects of the ACLD treatment are discussed. The motion and electric analytical formulation of the piezoelectric constrained layer are presented first. Based on the authors~ recent research on shells of revolution treated with passive constrained layer damping （PCLD）, the integrated first-order differential matrix equation of a shell of revolution partially treated with ring ACLD blocks is derived in the frequency domain. By virtue of the extended homogeneous capacity precision integration technology, a stable and simple numerical method is further proposed to solve the above equation. Then, the vibration responses of an ACLD shell of revolution are measured by using the present model and method. The results show that the control performance of the ACLD treatment is complicated and frequency-dependent. In a certain frequency range, the ACLD treatment can achieve better damping characteristics compared with the conventional PCLD treatment.     

乙二醇-聚(咪唑丙基-天冬酰胺)-聚丙氨酸三嵌段共聚物的合成及其pH-响应性药物控制释放性能的研究

聚天冬氨酸及其衍生物是一种具有良好生物相容性和可生物降解性的高分子材料, 被广泛应用于生物医药领域. 本研究通过大分子引发剂ω-胺基-α-甲氧基聚乙二醇引发N-羧基-α-氨基环内酸酐开环聚合和N-(3-氨丙基)咪唑侧基改性, 制备了一种侧链含有咪唑丙基的聚乙二醇-聚(咪唑丙基-天冬酰胺)-聚丙氨酸三嵌段共聚物. 在水溶液中, 此聚合物可自组装形成一种核-壳-冠型的三层共聚物胶束, 其中疏水性的聚丙氨酸链段自聚集形成胶束的核, 聚(咪唑丙基-天冬酰胺)链段形成具有pH-响应性的壳层, 用于包埋和释放药物, 外围的聚乙二醇链段可以提供一个稳定的水合冠层, 延长药物的体内循环时间. 利用咪唑环与游离阿霉素之间的π-π相互作用和疏水相互作用可以在自组装的过程中将阿霉素包埋到胶束内. 研究发现, 载药胶束随环境pH 值的降低药物的释放速率显著增加. 这主要是由于咪唑环在酸性条件下的质子化导致链段亲疏水性质发生明显变化.     

树状碳水化合物Ⅰ——分子设计与合成

选取三种不同结构的单糖,即2-乙酰氨基葡萄糖、氨基葡萄糖和葡萄糖,作为内核,采用发散收敛结合法,合成出一类含液晶基元的树状碳水化合物.以收敛法合成树枝状分子DOBOB酸(3,4,5-三[对-(十二烷氧基)苄氧基]苯甲酸), 再以发散法合成一系列卤代烷基酰化碳水化合物中间体,最后通过缩合反应在中间体的外围接上楔形液晶基元 DOBOB酸,获得目标化合物.     

Alpha decay chains from superheavy nuclei

Magic islands for extra-stable nuclei in the midst of the sea of fission-instability were predicted to be around Z=114, 124 or, 126 with N=184, and Z=120, with N=172. Whether these fission-survived superheavy nuclei with high Z and N would live long enough for detection or, undergo α-decay in a very short time, remains an open question. α-decay half lives of nuclei with 130≥Z≥100 have been calculated in a WKB framework using density-dependent M3Y interaction with Q-values from different mass formulae. The results are in excellent agreement with the experimental data. Fission survived Sg nuclei with Z=106, N=162 is predicted to have the highest α-decay half life (∼3.2 h) in the Z=106-108, N=160-164 region called small island/peninsula. Superheavy nuclei with Z>118 are found to have α-decay half lives of the order of microseconds or less.