Long Chain Fatty Acid Affects Excited State Branching in Bilirubin-Human Serum Protein Complex?

After binding to human serum albumin, bilirubin could undergo photo-isomerization and photo-induced cyclization process. The latter process would result the formation of a product, named as lumirubin. These photo induced behaviors are the fundamental of clinical therapy for neonatal jaundice. Previous studies have reported that the addition of long chain fatty acids is beneficial to the generation of lumirubin, yet no kinetic study has revealed the mechanism behind. In this study, how palmitic acid affects the photochemical reaction process of bilirubin in Human serum albumin (HSA) is studied by using femtosecond transient absorption and fluorescence up-conversion techniques. With the addition of palmitic acid, the excited population of bilirubin prefers to return to its hot ground state (S₀) through a 4 ps decay channel rather than the intrinsic ultrafast decay pathways (< 1 ps). This effect prompts the Z-Z to E-Z isomerization at the S$_0$ state and then further increases the production yield of lumirubin. This is the first time to characterize the promoting effect of long chain fatty acid in the process of phototherapy with femtosecond time resolution spectroscopy and the results can provide useful information to benefit the relevant clinical study.     

超短脉冲激光在掺Er3+ 磷酸盐玻璃中制备光波导的实验研究

超短脉冲激光通过非线性吸收调制光学材料折射率提供了一种高效制备集成三维光子器件的途径.掺Er³⁺磷酸盐玻璃由于其优异的特性以及在1.55μm通信波段附近的发射光谱,成为了集成光学主动增益材料中的研究热点.实验采用重复频率1 kHz,中心波长800 nm,脉冲宽度120 fs的钛宝石飞秒激光放大系统作为制备波导的光源,系统研究了加工参数对激光写入形貌、波导形成及光学特性的影响.实验结果表明,在狭缝整形辅助短焦物镜横向刻写条件下,写入脉冲能量为1.8μJ时,光波导可以在写入速度为10μm/s-160μm的较宽范围内形成;写入速度为40μm/s时,光波导写入脉冲能量参数窗口为1.6μJ-2.0μJ;波导写入深度在125μm-200μm范围时,波导横截面对称性较好且折射率修改明显;近场强度测量结果显示所制备波导近场强度分布对称,导光特性良好.通过有限差分法反推波导区域折射率修改分布,结果显示最大折射率修改为Δn=6.6×10^-4.截断传输损耗测量结果显示所制备波导的传输损耗低至0.91 dB/cm.     

低秩稀疏矩阵恢复的快速非单调交替极小化方法

针对低秩稀疏矩阵恢复问题的一个非凸优化模型,本文提出了一种快速非单调交替极小化方法.主要思想是对低秩矩阵部分采用交替极小化方法,对稀疏矩阵部分采用非单调线搜索技术来分别进行迭代更新.非单调线搜索技术是将单步下降放宽为多步下降,从而提高了计算效率.文中还给出了新算法的收敛性分析.最后,通过数值实验的比较表明,矩阵恢复的非单调交替极小化方法比原单调类方法更有效.     

Mirror symmetry,mirror map and applications to complete intersection Calabi-Yau spaces

We extend the discussion of mirror symmetry, Picard-Fuchs equations, instanton corrected Yukawa couplings and the topological one-loop partition function to the case of complete intersections with higher dimensional moduli spaces. We will develop a new method of obtaining the instanton corrected Yukawa couplings through a study of the solutions of the Picard-Fuchs equations. This leads to closed formulas for the prepotential for the Kähler moduli fields induced from the ambient space for all complete intersections in nonsingular weighted projective spaces. As examples we treat part of the moduli space of the phenomenologically interesting three-generation models which are found in this class. We also apply our method to solve the simplest model in which a topology change was observed and discuss examples of complete intersections in singular ambient spaces.     

Theoretical introduction to neutron scattering spectroscopy

Some basic background on the interaction of neutrons with condensed matter is given with emphasis on the differences with other experimental probes. Neutron scattering cross-sections are described for those dynamical processes that are likely to be of importance in chemical applications of inelastic neutron scattering.     

The structure and properties of medium-chain surfactant solutions: a case study of sodium octanoate

In the paper the most characteristic properties of binary sodium octanoate solutions of variable ion strengths are discussed. Both pre- and postmicellar association is investigated with reference to available scattering, spectroscopic and thermodynamic data. The focus is then placed on references dealing with, or referring to, results including sodium octanoate. A picture is offered illustrating the sodium octanoate micelle as a rather unstable entity including micelle sizes from oligomeric pre-associates up to some 20 monomers. Due to this circumstance the molecular features obtained with different scattering and spectroscopic techniques are rather divergent. However, the structure emerging describes the micelle as consisting of a small “dry” hydro-carbon core with a radius shorter than the fully extended heptyle chain of the octanoate. Instead a “rough shell” encompassing the hydrated polar head groups, some “wet” methylene/methyle groups and the hydrated counterions separates the micelle from the surrounding solvent. On purely geometric grounds this hydrated shell represent, however, more than 50% of the micellar volume. The numerous distinct properties of medium-chain surfactants should thence not, as is frequently done, be related to those of long-chain surfactants! At high concentrations of octanoate or salt, or upon solubilization, the average degree of water contact seem to diminish due to an increased aggregation number or a lack of available “free” hydration water. The latter effect is suggested to produce observable effects at the second critical concentration as well as close to the phase boundary. The influence of solubilizates are dealth with only when the results provide significant information on the properties of the binary system.     

Pressure-induced phase transition in an orthorhombic C60 crystal

X-ray diffraction studies of an orthorhombic C₆₀ single crystal grown from CS₂ solution have revealed a phase transition to a monoclinic phase between 1.1 and 2.2GPa. Compressibility of three principal axes is measured up to 3GPa and found to be nearly isotropic. Its bulk modulus is obtained as 10.5±1.9GPa, and this crystal is more compressible than an fcc one. We discuss the structural characteristic differences under pressure between the orthorhombic crystal and the fcc crystal.     

Thermovision monitoring of gas-phase fluorescence induced by cw CO2 laser radiation

Applying thermovision monitoring, spatial distribution of gas-phase fluorescence in the wavelength region 2–5.4/um induced by CO₂ laser radiation is displayed. Experimental results demonstrate that the spatial distribution of the fluorescence is effected not only by the convection in a reaction cell but it also depends on V-T energy transfer relaxation time. Relatively slow relaxation compared to fast convection can cause that dominant portion of excited molecules is quenched on the cell walls. The used thermovision technique allows to determine both the threshold and the steady-state of convection generated by cw CO₂ laser beam absorption.     

离子液体中芳烃侧链分子氧催化氧化反应研究

分别以离子液体[Hex-mim]BF4, [Bmim]BF4, [Bmim]PF6和[Omim]BF4为溶剂, Co(Ⅱ), Mn(Ⅱ)或Ni(Ⅱ)/NHPI(AIBN)为复合催化剂, 考察了不同离子液体-催化剂体系中常压分子氧氧化芳烃侧链烷基的反应. 在[Hex-mim]BF4中, Co(Ⅱ)或Mn(Ⅱ)/NHPI可有效地催化芳烃侧链烷基的分子氧氧化. 在优化条件下, 乙苯、正丙苯和正丁苯分别以高达90%, 94%和93%的收率得到相应的芳香酮; 甲苯和对位取代甲苯以32%~47%的收率被氧化为相应的芳香酸. 离子液体及金属催化剂体系在减压下除水后, 可循环使用.