The use of Taguchi method to optimize the laser welding of sealing neuro-stimulator

Titanium has high strength-to-weight ratio, corrosion resistance, excellent weldability and well biocompatibility. It is applied in various fields, such as medical and aerospace industry. Laser welding is major joint technology for titanium sealing in medical field. It is difficult for sealing thin titanium shell of the neuro-stimulator by laser lap welding. The key point for welding quality is the combination of laser welding parameters. In this paper, the effects of the Nd: YAG laser welding parameters is discussed and analyzed at first, and then a novel application of Taguchi's matrix method is proposed to optimize the selection of laser seal welding thin titanium shell, including the main parameters such as laser power, welding speed, defocusing amount and shield gas, finally the manufacture process for sealing neuro-stimulator is confirmed. The results show that Taguchi method has optimized process parameters of the laser welding on sealing thin titanium shell of the neuro-stimulator, and the device is equipped properly in medical treatments.     

波转子内部非定常流动分析

为进一步了解波转子内部流动机理,本文利用数值方法分析了径流与轴流波转子内部流动,得出以下结论:模拟的流场特征与设计要求相符.计算结果充分显示了波转子内不同能量密度的气体实现能量交换的过程,同时也显示了端口非瞬时开放等非定常过程的影响.     

星光观测蒙气差补偿技术

为了消除大气内观星时蒙的影响,提高载体定姿精度,提出了一种蒙气差补偿算法。首先给出了补偿过程涉及的姿态转移矩阵,并完成了相关矢量坐标映射变换;接着在星敏感器坐标系内,用两矢量内积法求得视天顶距;最后利用几何公式列出了以真星光矢量投影点估计位置为未知量的方程组,作为星敏感器任意姿态下蒙气差补偿算法模型。在没有任何误差的条件下对模型有效性进行了仿真,10-6 pixel量级的位置估计精度表明了算法的有效性。加入不同量级的陀螺漂移误差进行了仿真,给定的漂移误差对于蒙气差补偿模型的估计精度影响甚微,仿真结果表明在捷联载体存在一定姿态误差的前提下,蒙气差补偿模型也是适用的,补偿后的星像坐标用以实现星光姿态确定,并进一步对陀螺漂移完成补偿。     

New band structures in ~（107）Ag

High spin states in ¹⁰⁷Ag are studied via the ¹⁰⁰Mo(¹¹B, 4n)¹⁰⁷Ag reaction at an incident beam energy of 60 MeV. Prompt γ-γ coincidence and DCO ratios are measured by the detector arrays in CIAE. The level scheme has been updated and a new negative band belonging to ¹⁰⁷Ag is identified. The new negative side band has been constructed and its configuration is tentatively assigned to πg_9/2 νh_11/2(g_7/2/d_5/2).     

Design,Synthesis and Biological Evaluation of (2′,5′ and 3′5′-Linked) cGAMP Analogs that Activate Stimulator of Interferon Genes (STING)

Stimulator of interferon genes (STING) is an endoplasmic reticulum adaptor transmembrane protein that plays a pivotal role in innate immune system. STING agonists, such as endogenous cyclic dinucleotide (CDN) cyclic GMP-AMP (cGAMP), have been used in diverse clinical research for immunogenic tumor clearance, antiviral treatments and vaccine adjuvants. CDNs containing noncanonical mixed 3′-5′ and 2′-5′ phosphodiester linkages show higher potency in the activation of the STING pathway. In this study, a series of 2′3′-CDNs were designed and synthesized through a modified one-pot strategy. We then established a surface plasmon resonance (SPR)-based binding assay to quantify the binding affinities of synthesized CDNs for human STING, which requested a minuscule amount of sample without any pretreatment. Using this assay, we identified compound 8d (K_D = 0.038 μM), a novel CDN that showed higher binding affinity with hSTING than cGAMP (K_D = 0.543 μM). Cellular assays confirmed that 8d could trigger the expression of type I IFNs and other proinflammatory cytokines more robust than cGAMP. 8d also exhibited more resistant than cGAMP to enzymatic cleavage in vitro, indicating the successful improvement in drug availability. These findings provide guidelines for the design and structural optimization of CDNs as STING agonists.     

A bioinspired magnetic responsive cilia array surface for microspheres underwater directional transport

Bio-inspired surfaces are usually designed by imitating the surface properties of a particular biological species,or combing with the surface characteristics of multiple biological species to construct a cross-species surface.Herein,inspired by the structure and rhythmic swing of human pulmonary cilia,and the directional migration of pigeons by geomagnetic field,an integrated system of biomimetic hydrophobic magnetic cilia array surface with reversible deformation properties and excellent magnetic response performance for solid microspheres underwater transport is designed and constructed.Driven by an external magnetic field,the magnetic responsive cilia array surface can directionally and continuously transport microspheres underwater in periodic motion.This work will shed new light on the designing of micromanipulation systems for micro-objects transport,and promote the practical application of micro-operating systems in underwater transportation and drug delivery.     

Bioinspired Green Composite Lotus Fibers

Owing to the growing global environmental problems, demands for environmentally friendly, fully biodegradable sustainable composites have substantially increased across various industries. Inspired by the composite structure of cocoon silk, we fabricated a fully green composite fiber (GCF) that is based on the lotus fiber (LF) and a biodegradable polymer, namely poly(vinyl alcohol) (PVA). After the formation of cross‐linkages between the LF and PVA, the mechanical properties of this bioinspired GCF had substantially improved. In particular, the specific mechanical properties are superior to those of cocoon silk and other natural fibers. These findings suggest that LFs may be used as reinforcement materials for the fabrication of bulk green materials for various industries, such as the textile, medical, automobile, and aerospace industries.     

Controlled Directional Water‐Droplet Spreading on a High‐Adhesion Surface

Controlled directional spreading of a droplet on a smart high‐adhesion surface was made possible by simply controlling anodic oxidation. The wettability gradient of the surface was controlled from 0.14 to 3.38° mm^?1 by adjusting the anodic oxidation conditions. When a water droplet made contact with the substrate, the droplet immediately spread in the direction of the wettability gradient but did not move in other directions, such as those perpendicular to the gradient direction, even when the surface was turned upside down. The spreading behavior was mainly controlled by the wettability gradient. Surfaces with a V‐ or inverse‐V‐shaped wettability gradient were also formed by the same method, and two droplets on these surfaces spread either toward or away from one another as designed. This method could be used to oxidize many conductive substrates (e.g., copper, aluminum) to form surfaces with variously shaped wettability gradients. It has potential for application in microfluidic devices.     

Recrystallization‐Induced Self‐Assembly for the Growth of Cu2O Superstructures

The assembly of inorganic nanoparticles (NPs) into 3D superstructures with defined morphologies is of particular interest. A novel strategy that is based on recrystallization‐induced self‐assembly (RISA) for the construction of 3D Cu₂O superstructures and employs Cu₂O mesoporous spheres with diameters of approximately 300 nm as the building blocks has now been developed. Balancing the hydrolysis and recrystallization rates of the CuCl precursors through precisely adjusting the experimental parameters was key to success. Furthermore, the geometry of the superstructures can be tuned to obtain either cubes or tetrahedra and was shown to be dependent on the growth behavior of bulk CuCl. The overall strategy extends the applicability of recrystallization‐based processes for the guided construction of assemblies and offers unique insights for assembling larger particles into complicated 3D superstructures.     

Dehydrogenative N‐Incorporation: A Direct Approach to Quinoxaline N‐Oxides under Mild Conditions

An efficient method for the synthesis of quinoxaline N‐oxides proceeds by the dehydrogenative N‐incorporation of simple imines by C(sp²)? H and C(sp³)? H bond functionalization. The overall transformation involves the cleavage of three C? H bonds. The reaction is easily handled and proceeds under mild conditions. Simple and readily available tert‐butyl nitrite (TBN) was employed as the NO source.