高效前沿分析的发展及在药物-蛋白结合研究中的应用

介绍了高效前沿分析方法的原理、特点、种类，综述了它在药物与蛋白结合研究中的应用及国内外研究概况；通过与高效液相色谱／前沿分析比较，阐明了毛细管电泳／前沿分析在药物蛋白结合研究中的优势；分析了在药物与蛋白结合研究中所采用的各种研究方法，通过与这些研究方法的比较，阐明了高效前沿分析的优越性及其广阔的应用前景，同时提出了在高效前沿分析方法中有待完善和注意的问题。     

甲胺化反应催化剂稀土改性丝光沸石的研究

研究了稀土改性丝光沸石催化剂对常压固定床上甲胺化反应的活性及选择性的影响，结果表明，以钇改性丝光沸石催化剂的活性及对二甲胺的选择性最佳。催化剂表征结果表明，稀土改性丝光沸石主要是引起丝光沸石中Ｂ酸中心发生变化，而对丝光沸石的晶体结构及表面硅铝原子比基本不产生影响。稀土改性能增强催化剂的热稳定性，延长催化剂的寿命。     

Microcalorimetric investigation of the growth of the <Emphasis Type="Italic">Escherichia coli</Emphasis> DH5α in different antibiotics

The effects of Amoxicillin Sodium and Cefuroxime Sodium on the growth of E. coli DH5α were investigated by microcalorimetry. The metabolic power-time curves of E. coli DH5α growth were determined by using a TAM air isothermal microcalorimeter at 37°C. By evaluation of the obtained parameters, such as growth rate constants (k), inhibitory ratio (I), the maximum heat power (P _m) and the time of the maximum heat power (t _m), one found that the inhibitory activity of Amoxicillin Sodium vs. E. coli DH5α is enhanced with the increasing of the Amoxicillin Sodium concentration, and the Cefuroxime Sodium has a stimulatory effect on the E. coli DH5α growth when the concentration is about 1 μg mL⁻¹. The IC₅₀ for the Amoxicillin Sodium and the Cefuroxime Sodium are 1.6 and 2.0 μg mL⁻¹, respectively, it implicates that the E. coli DH5α is more sensitive to Amoxicillin Sodium than Cefuroxime Sodium.     

Synthesis of alpha-MoTe2 nanorods via annealing Te-seeded amorphous MoTe2 particles

Semiconductor alpha-MoTe2 nanorods have been synthesized by annealing Te-seeded particles of an amorphous MoTe2 intermediate. This intermediate is prepared by a solution reaction between Mo(CO)6 and elemental Te in diphenylmethane. The as-synthesized products were characterized by structural, compositional, and morphological techniques of X-ray diffraction, selected area electron diffraction, selected area energy dispersive spectroscopy, energy dispersive X-ray analysis, X-ray photoelectron spectroscopy, transmission electron microscopy, and high-resolution transmission electron microscopy. The results of the annealing process are MoTe2 nanorods with diameters of 50-200 nm and lengths ranging from 0.1 to 3.0 microm. Here, the rodlike structure of MoTe2 is reported for the first time, and added to the list as one kind of new morphology of MoTe2 nanomaterials. A mechanism for the formation of the nanorods is proposed. The sandwich-layered structure of Te-Mo-Te and the similarity in the structure between hexagonal alpha-MoTe2 and hexagonal Te are responsible for the formation of nanorods of MoTe2.     

羧酸铜催化反应的研究——Ⅰ.羧酸铜催化醛肟转变为睛

本文报道了在多种羧酸铜催化下,醛肟在含有氰基的溶剂中(如CH_3CN、CH_3OCH_2CH_2CN等),均可脱水转变成相应的腈。反应条件温和,产率较高。具有不同空间和电性效应取代基的羧酸铜对反应的产率影响不大。实验中还发现溶剂乙腈参与了上述反应。     

Sesquiterpenoids from the Rhizome of Ligularia virgaurea

Two novel sesquiterpene dimers, compounds 1 and 2 , were isolated from the rhizome of Ligularia virgaurea, together with the six known sesquiterpenoids 3 – 8 . Their structures were established by physico‐chemical and spectroscopic methods, especially by means of 1D‐ and 2D‐NMR as well as HR‐MS analyses. A mechanism based on a classical Diels–Alder cyclization is proposed for the formation of the dimer 1 from the precursors 8 and the quinone form of 6 (Scheme).     

甲基丙烯酸羟烷基酯与丙烯腈或丙烯酰胺共聚合的研究

测定了亲水性甲基丙烯酸羟烷基酯如HEMA、MHPMA分别与AN或AAM,在60℃不同溶剂中自由基聚合反应的竞聚率。AN(M_1)-HEMA(M_2)共单体,在DMSO或DMF溶剂以AIBN或KPS-IPA引发剂条件下共聚,用Kelen-Tüds法计算的竞聚率变化不大,r_1=0.22-0.25、r_2=0.97-1.05,说明在此均相溶液共聚中,所用的溶剂及引发剂对竞聚率的影响较小,这两种单体能很好共聚。但AAM-MHPMA或AAM-HEMA共单体时,r_1与r_2值相差很大,如前者r_1=0.0433、r_2=3.98,后者r_1=0.0535、r_2=1.89,说明不易共聚,共聚物中主要是MHPMA或HEMA组分。     

A new two‐dimensional CdII coordination polymer constructed by pyrazine‐2,3‐dicarboxyl­ate

In the title compound, poly[μ₅‐pyrazine‐2,3‐dicarboxyl­ato‐cadmium(II)], [Cd(C₆H₂N₂O₄)]_n or [Cd(pdc)]_n, where pdc is the pyrazine‐2,3‐dicarboxyl­ate anion, the Cd^II atom is six‐coordinated by five carboxyl­ate O atoms and one N atom from five different pdc ligands in a distorted octa­hedral CdO₅N coordination geometry. Two Cd^II atoms are bridged by carboxyl­ate groups of the pdc ligands to create a dimeric unit. The dimeric units are further connected by the pdc ligands to generate an inter­esting two‐dimensional structure.     

MICRO-PHASE SAEPARATION IN EPOXY RESIN WATERBORNE PARTICLES DURING CURING PROCESS

Sub-micron sized phenolic epoxy resin waterborne particles were prepared by phase inversion emulsification. Micro-phase separation occurred during the curing process at high temperature. The as-prepared samples possessed one glass transition temperature （Tg） and two exothermal processes during DSC heating scannings. After being thermally treated above the exothermal peak temperature, they possessed two glass transition temperatures with the disappearance of exothermal peaks, whilst a core/shell structure was formed. This was likely related with the outward diffusion of reactive oligomers to the outer layer of particles.     

Fine structures of zeolite-Linde-L (LTL): surface structures, growth unit and defects

High-resolution electron microscopy (HREM) has been used to image the surface structure of nano- and micrometer-sized synthetic crystals of zeolite-Linde-L (LTL). Columnar holes and rotational, nano-sized, wheel-like defects were observed within the crystals, where the hole has a minimum size equal to that of the rotational defect. Predictions of surface structure from atomistic computer simulation concur with the observations from HREM and provide insight into the crystal growth mechanism of perfect and defective LTL. Analysis of the energetics of the formation of rotational defect structures reveals that the driving force for defect creation is thermodynamic and furthermore, the rotational defects could be created in high concentrations. Formation of a columnar hole is found to be slightly energetically unfavourable and therefore we speculate that the incidence of both rotational and nano-sized vacancy defects is strongly dependent on kinetic factors and reaction conditions. The morphology of nano- and microcrystalline LTL is contradistinct and we use insights from simulation to propose an explanation of the disparity in crystal shape.