Despite the versatility of amphoteric molecules, stable and easily accessible ones are still limitedly known. As a result, the discovery of new amphoteric reactivity remains highly desirable. Herein we introduce 3-aminooxetanes as a new family of stable and readily available 1,3-amphoteric molecules and systematically demonstrated their amphoteric reactivity toward polarized π-systems in a diverse range of intermolecular [3 + 2] annulations. These reactions not only enrich the reactivity of oxetanes, but also provide convergent access to valuable heterocycles.Despite the versatility of amphoteric molecules, stable and easily accessible ones are still limitedly known.Amphoteric molecules, which bear both nucleophilic and electrophilic sites with orthogonal reactivity, represent an attractive platform for the development of chemoselective transformations.1 For example, isocyanides are well-established 1,1-amphoteric molecules, with the terminal carbon being both nucleophilic and electrophilic, and this feature has enabled their exceptional reactivity in numerous multi-component reactions.2 In the past few decades, substantial effort has been devoted to the search for new amphoteric molecules.1–5 Among them, 1,3-amphoteric molecules proved to be versatile. The Yudin and Beauchemin laboratories have independently developed two types of such molecules, α-aziridine aldehydes and amino isocyanates, respectively.4,5 With an electrophilic carbon and a nucleophilic nitrogen in relative 1,3-positions, these molecules are particularly useful for the chemoselective synthesis of heterocycles with high bond-forming efficiency without protective groups (Fig. 1). However, such elegant amphoteric systems still remain scarce. Therefore, the development of new stable amphoteric molecules with easy access remains highly desirable.Open in a separate windowFig. 1Representative [1,3]-amphoteric molecules versus 3-aminooxetanes.In this context, herein we introduce 3-aminooxetanes as a new type of 1,3-amphoteric molecules and systematically demonstrate their reactivity in a range of [3 + 2] annulations, providing rapid access to diverse heterocycles. Notably, 3-aminooxetanes are bench-stable and either commercially available or easily accessible. However, their amphoteric reactivity has not been appreciated previously.Oxetane is a useful functional group in both drug discovery and organic synthesis.6–9 Owing to the ring strain, it is prone to nucleophilic ring-opening, in which it serves as an electrophile (Scheme 1A).6–8 We envisioned that, if a nucleophilic group is installed in the 3-position (e.g., amino group), such molecules should exhibit 1,3-amphoteric reactivity due to the presence of both nucleophilic and electrophilic sites (Scheme 1B). Importantly, the 1,3-relative position is crucial for inhibiting self-destructive intra- or intermolecular ring-opening (i.e. the 3-nucleophilic site attack on oxetane itself) due to high barriers. Thus, such orthogonality is beneficial to their stability. In contrast, the nucleophilic site is expected to react with an external polarized π bond (e.g., X = Y, Scheme 1B), which enables a better-positioned nucleophile (Y) to attack the oxetane and cyclize. Thus, a formal [3 + 2] annulation should be expected. Unlike the well-known SN2 reactivity of oxetanes with simple bond formation, this amphoteric reactivity would greatly enrich the chemistry of oxetanes with multiple bond formations and provide expedient access to various heterocycles. In contrast to the conventional approaches that require presynthesis of advanced intermediates (e.g., intramolecular ring-opening),8 the exploitation of such amphoteric reactivity in an intermolecular convergent manner from simple substrates would be more practically useful. Moreover, more activation modes could be envisioned in addition to oxetane activation. In 2015, Kleij and coworkers reported an example of cyclization between 3-aminooxetane and CO2 in 55% yield, which provided a pioneering precedent.10 However, a systematic study to fully reveal such amphoteric reactivity in a broad context remains unknown in the literature.Open in a separate windowScheme 1Typical oxetane reactivity and the new amphoteric reactivity.To test our hypothesis, we began with the commercially available 3-aminooxetanes 1a and 1b as the model substrates. Phenyl thioisocyanate 2a and CS2 were initially employed as reaction partners, as they both have a polarized CS bond as well as a relatively strong sulfur nucleophilic motif. Moreover, the resulting desired products, iminothiazolidines and mercaptothiazolidines, are both heterocycles with important biological applications (Fig. 2).11 To our delight, simple mixing these two types of reactants in DCM resulted in spontaneous reactions at room temperature without any catalyst. The corresponding [3 + 2] annulation products iminothiazolidine 3a and mercaptothiazolidine 4a were both formed with excellent efficiency (Scheme 2). It is worth mentioning that catalyst-free ring-opening of an oxetane ring is rarely known, particularly for intermolecular reactions.6–9 In this case, the high efficiency is likely attributed to the suitable choice and perfect position of the in situ generated sulfur nucleophile.Open in a separate windowFig. 2Selected bioactive molecules containing iminothiazolidine and mercaptothiazolidine motifs.Open in a separate windowScheme 2Initial results between 3-aminooxetanes and thiocarbonyl compounds.The catalyst-free annulation protocol is general with respect to various 3-aminooxetanes and isothiocyanates. A range of iminothiazolidines and mercaptothiazolidines were synthesized with high efficiency under mild conditions (Scheme 3). Many of them were obtained in quantitative yield. Quaternary carbon centers could also be generated from 3-substituted 3-aminooxetanes (e.g., 3j). The structure of product 3b was unambiguously confirmed by X-ray crystallography.Open in a separate windowScheme 3Formal [3 + 2] annulation with isothiocyanates and CS2. Reaction conditions: 1 (0.3–0.4 mmol), 2 (1.1 equiv.) or CS2 (1.5 equiv.), DCM (2 mL), RT, 3 h for 3 and 36 h for 4. Yields are for the isolated products.With the initial success of thiocarbonyl partners, we next turned our attention to isocyanates, in which the carbonyl group serves as the [3 + 2] annulation motif. Compared with sulfur as the nucleophilic site in the above cases, the oxygen atom is less nucleophilic. As expected, initial tests of the reactivity by mixing 1b and 5a resulted in no desired annulation product 6a in the absence of a catalyst (Table 1, entry 1). Next, Brønsted acids, including TsOH and the super acid HNTf2, were examined as catalysts, but with no success (entries 2 and 3). We then resorted to various Lewis acids, particularly those oxophilic ones, in hope of activating the oxetane unit. Unfortunately, many of them still remained ineffective (e.g., ZnCl2, AuCl, and FeCl3). However, to our delight, further screening of stronger Lewis acids helped identify Sc(OTf)3, Zn(OTf)2, and In(OTf)3 to be effective at room temperature, leading to the desired iminooxazolidine product 6a in good yield (entries 7–9). Its structure was confirmed by X-ray crystallography. Nevertheless, aiming to search for a cheaper catalyst, we continued to optimize this reaction at a higher temperature using previous ineffective catalysts. Indeed, FeCl3 was found to be effective at 80 °C (61% yield, entry 10), while Brønsted acid TsOH remained ineffective at this temperature (entry 11). Notably, decreasing the loading of FeCl3 to 1 mol% led to a higher yield (89% yield, entry 12). However, further decreasing to 0.5 mol% resulted in slightly diminished efficiency (entry 13).Reaction conditions for annulation with isocyanatesa
Entry
Catalyst
Yieldb (%)
1
—
0
2
TsOH·H2O
0
3
HNTf2
0
4
ZnCl2
0
5
AuCl
0
6
FeCl3
0
7
Sc(OTf)3
74
8
Zn(OTf)2
78
9
In(OTf)3
90
10
FeCl3c
61
11
TsOH·H2Oc
0
12
FeCl3c (1 mol%)
89(84)d
13
FeCl3c (0.5 mol%)
85
Open in a separate windowaReaction scale: 1b (0.1 mmol), 5a (0.1 mmol), catalyst (10 mol%), toluene (1 mL).bYield based on analysis of the 1H NMR spectra of the crude reaction mixture using trichloroethylene as an internal reference. For all the entries, the urea product from simple amine addition to isocyanate 5a accounts for the mass balance.cRun at 80 °C.dIsolated yield.While there are multiple effective catalysts, FeCl3 was selected for the scope study in view of its low price. Various substituted 3-aminooxetanes and isocyanates were subjected to this annulation protocol (Scheme 4). The corresponding iminooxazolidine products were all obtained in good to excellent yields. Isocyanates containing an electron-donating or electron-withdrawing group were both suitable reaction partners. Remarkably, a 1.5 mmol scale reaction of 6a also worked efficiently.Open in a separate windowScheme 4Formal [3 + 2] annulation between 3-aminooxetanes and isocyanates. Reaction scale: 1 (0.3 mmol), 5 (0.3 mmol), FeCl3 (1 mol%), toluene (2 mL).Although (thio)isocyanates and CS2 have been successfully utilized in the formal [3 + 2] annulation with 3-aminooxetanes, these partners are relatively reactive. We were curious about whether the CO bond in relatively inert molecules could react in a similar manner. For example, the CO bond in CO2 is both thermodynamically and kinetically inert relative to typical organic carbonyl groups. However, as a cheap, abundant and green one-carbon source, CO2 has been a subject of persistent investigations owing to its versatility in various transformations leading to valuable materials.12 Specifically, if CO2 could be employed as a partner for the [3 + 2] annulation with 3-aminooxetanes, it would represent an attractive synthesis of oxazolidinones, a well-known heterocycle with applications in both organic synthesis and medicinal chemistry.13 In this context, we next studied the possibility of utilizing CO2 in our annulation.As expected, the reaction between 1b and CO2 at 1 atmospheric pressure did not proceed without a catalyst (Table 2, entry 1). Next, we examined representative Lewis acids, such as Sc(OTf)3, In(OTf)3 and FeCl3. Among them, Sc(OTf)3 exhibited the highest catalytic activity at room temperature (22% yield, entry 2). The reaction efficiency could be improved at 80 °C (65% yield, entry 6), but no further improvement could be made at a higher temperature or with other solvents. Next, we resorted to organic nitrogen bases, as they were known as effective activators of CO2.14 While Et3N and DABCO were completely ineffective for the reaction in MeCN at 80 °C, fortunately, TMG, TBD, and DBU were competent for the desired process (entries 7–11). Among them, DBU exhibited the best performance, leading to the desired product 7a in 89% yield (entry 11). It is worth noting that the polar solvent MeCN was found to be crucial for the base-catalyzed reactivity. Less polar solvents, such as toluene, DCE or THF, completely shut down the reaction. We believe that effective stabilization of certain polar intermediates involved here is critically beneficial to decreasing the reaction barrier. Finally, unlike the previous Lewis acid-catalyzed annulation with isocyanates, this base-catalyzed [3 + 2] annulation with CO2 proceeds via a different activation mode (i.e., to activate CO2 rather than oxetane). We believe that expansion of possible activation modes in this type of amphoteric reactivity will enrich the chemistry of oxetanes.Reaction conditions for annulation with CO2a
Entry
Catalyst
T
Conv. (%)
Yield (%)
1
—
RT
0
0
2
Sc(OTf)3
RT
48
22
3
In(OTf)3
RT
33
9
4
Zn(OTf)2
RT
7
0
5
Sc(OTf)3
60 °C
100
61
6
Sc(OTf)3
80 °C
100
65
7
Et3N
80 °C
0
0
8
DABCO
80 °C
5
0
9
TMG
80 °C
72
54
10
TBD
80 °C
100
88
11
DBU
80 °C
100
89
Open in a separate windowaReaction scale: 1b (0.1 mmol), CO2 (1 atm), solvent (0.5 mL). Yields based on analysis of the 1H NMR spectra of the crude reaction mixture using CH2Br2 as an internal standard.We next examined the scope of this CO2-fixation process. Unfortunately, at a larger scale (0.5 mmol), the same condition (entry 11, Table 2) could not lead to complete conversion within 12 h. Therefore, further optimization aiming to accelerate the reaction was performed. Indeed, a higher concentration (1.0 M) resulted in a higher rate without affecting the yield. As shown in Scheme 5, a wide variety of 3-aminooxetanes were smoothly converted to the corresponding oxazolidinones in high yields. Both electron-donating and electron-withdrawing substituents on the N-benzyl group did not affect the efficiency. Heterocycle-based N-benzyl or N-allylic substituents are all suitable substrates. However, for regular alkyl substituents, such as homobenzyl (7h) or n-butyl (7j), the stronger base catalyst TBD was needed to achieve good efficiency. Furthermore, this reaction can tolerate steric hindrance in the 3-position of the oxetane (7k), where a quaternary carbon center could be incorporated. However, increasing the size of the N-substituent, such as the secondary alkyl groups in 7i and 7l, did influence the reactivity, thus requiring a higher temperature (100 °C). This process exhibited good compatibility with diverse functional groups, such as ethers, pyridines, aryl halides, olefins, silyl-protected alcohols, and phthalimides. Finally, this protocol is also capable of generating various oxazolidinones embedded in a different structural context, such as chiral oxazaolidinone 7l, bis(oxazolidinone) 7m, and polyheterocycle-fused oxazolidinone 7o.Open in a separate windowScheme 5Formal [3 + 2] annulation between 3-aminooxetanes and CO2. aReaction scale: 1 (0.5 mmol), CO2 (1 atm), DBU (10 mol%), MeCN (0.5 mL). Isolated yield. bRun with TBD as the catalyst. cRun with DMF as solvent at 100 °C.In summary, 3-aminooxetanes have been systematically demonstrated, for the first time, as versatile 1,3-amphoteric molecules. They are a new addition to the limited family of amphoteric molecules. Though previously unappreciated, these molecules exhibited various advantages over the related known 1,3-amphotric molecules (e.g., α-aziridine aldehydes and amino isocyanates), including easy access and extraordinary stability. The perfect position of the nucleophilic nitrogen together with the orthogonal electrophilic carbon allowed them to participate in a diverse range of intermolecular formal [3 + 2] annulations with polarized π-systems, leading to rapid access to various valuable nitrogen heterocycles. Different types of polarized double bonds, from reactive (thio)isocyanates to inert CO2, all participated efficiently in these highly selective annulations with or without a suitable catalyst. Furthermore, the involvement of more functional groups in such amphoteric reactivity allowed manifold activation modes, thereby greatly enriching the reactivity of the already versatile oxetane unit to a new dimension. These reactions, proceeding in an intermolecular convergent manner from readily available substrates, provide expedient access to various valuable nitrogen heterocycles, thus being complementary to those traditional methods that either required multiple steps or less available substrates. More studies on the 1,3-amphoteric reactivity of 3-oxetanes, particularly those with other partners as well as their asymmetric variants, are ongoing in our laboratory. 相似文献
The cover picture shows a typical building within the Campus of Xiamen University displaying Chen Jiageng (Tan Kah Kee)'s style. Just like many beautiful buildings designed and constructed by human, Nature “designs and constructs” a huge number of useful molecules with fascinating structures called natural products. Many natural products possess a fused six or seven‐membered carbocyclic unity. On page 315–322, the Huang's group disclosed a three‐step “[2+n]” annulation method for the construction of fused six and seven‐membered carbocyclic enimines and enones. The method starts from simple cyclic ketones and terminal olefinic amides, and relies on both the Suzuki coupling reaction and the olefin‐amide based Friedel‐Crafts type acylating reaction, a method developed by Huang and coworkers.
To estimate the number of peaks and to find the individual peak positions in an overlapped signal, a new method called maximum spectrum of continuous wavelet transform (MSCWT) was developed by extracting the maximum coefficients of continuous wavelet transform (CWT). The peak position in MSCWT was the same as that in its original signal. In this process, CWT was performed not on a single dilation but on an appreciation dilation range. To obtain such a range, a new criterion was introduced to choose a center dilation, which was used to form the dilation range. If Cdilation denoted the center dilation, the proper dilation range was [Cdilation -6 +/- 2, Cdilation +1 +/- 1]. The Mexican Hat function was an analytical wavelet. Utilizing the information of the peak number and the position detected by MSCWT, a fitting route was performed to recover the original signal. One simulated and four true overlapped signals, including high performance liquid chromatography (HPLC), ultraviolet-visible (UV) spectrum, and differential pulse voltammetric (DPV), were processed, and the results indicated that MSCWT could detect an overlapped peak number and position, and the curve fitting based on information of MSCWT had a higher accuracy. The proposed method was an efficient one in resolving different types of overlapped signals. 相似文献
The electrochemical performance of V2O5 has been studied in propylene carbonate (PC)-containing magnesium perchlorate [Mg(ClO4)2] electrolytes in view of their application as positive electrode in the rechargeable magnesium batteries. V2O5 exhibited good properties in hosting magnesium ions and its electrochemical performance depended on the amount of H2O in the electrolytes. The highest first discharge specific capacities of V2O5 electrode was up to 158.6 mAh/g in 1 mol dm(-3) Mg(ClO4)2 + 1.79 mol dm(-3) H2O/PC electrolytes. Electrochemical impedance spectroscopy (EIS) and charging-discharging tests showed that a reasonable amount of H2O in the electrolyte solution facilitated the electrochemical performance of V2O5 electrodes. 相似文献
