全文获取类型
收费全文 | 836篇 |
免费 | 35篇 |
国内免费 | 6篇 |
专业分类
化学 | 662篇 |
晶体学 | 5篇 |
力学 | 37篇 |
数学 | 93篇 |
物理学 | 80篇 |
出版年
2023年 | 4篇 |
2022年 | 6篇 |
2021年 | 17篇 |
2020年 | 12篇 |
2019年 | 18篇 |
2018年 | 11篇 |
2017年 | 10篇 |
2016年 | 36篇 |
2015年 | 15篇 |
2014年 | 24篇 |
2013年 | 53篇 |
2012年 | 62篇 |
2011年 | 70篇 |
2010年 | 28篇 |
2009年 | 49篇 |
2008年 | 66篇 |
2007年 | 58篇 |
2006年 | 39篇 |
2005年 | 43篇 |
2004年 | 31篇 |
2003年 | 42篇 |
2002年 | 37篇 |
2001年 | 17篇 |
2000年 | 20篇 |
1999年 | 8篇 |
1998年 | 10篇 |
1997年 | 12篇 |
1996年 | 17篇 |
1995年 | 3篇 |
1994年 | 8篇 |
1993年 | 6篇 |
1992年 | 3篇 |
1990年 | 2篇 |
1987年 | 1篇 |
1986年 | 4篇 |
1985年 | 7篇 |
1984年 | 3篇 |
1981年 | 4篇 |
1980年 | 4篇 |
1978年 | 3篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1975年 | 2篇 |
1974年 | 2篇 |
1973年 | 1篇 |
1972年 | 1篇 |
1970年 | 2篇 |
1959年 | 1篇 |
1923年 | 1篇 |
1922年 | 1篇 |
排序方式: 共有877条查询结果,搜索用时 125 毫秒
101.
Pitois A de las Heras LA Zampolli A Menichetti L Carlos R Lazzerini G Cionini L Salvatori PA Betti M 《Analytical and bioanalytical chemistry》2006,384(3):751-760
Boron neutron capture therapy (BNCT) is a bimodal radiotherapeutic treatment based on the irradiation of neoplastic tissues
with neutrons after the tissues have selectively accumulated molecules loaded with nuclides with large neutron capture cross-sections
(such boron-10). Boron-10 carriers have been tested to a limited extent, and clinical trials have been conducted on sulfhydryl
borane (10B-BSH) and boronophenylalanine (10B-BPA). However, precise and accurate measurements of boron-10 concentrations (0.1–100 μg/g) in specimens and samples of limited
size (μg scale) are needed in order to be able to biologically characterise new compounds in predictive tissue dosimetry,
toxicology and pharmacology studies as well as in clinical investigations. A new approach based on fast separation and detection
of 10B-BPA performed by coupling capillary electrophoresis to electrospray mass spectrometry is reported. This method allows the
quantitative analysis and characterisation of 10B-BPA in a short time with a high separation efficiency. Detection limits of 3 μM for 10B-BPA and 30 ng/mL for 10B were obtained with CE–ESI–MS. A quantification limit of 10 μM for 10B-BPA (100 ng/mL for 10B) was attained. The total boron-10 concentration was determined by high-resolution inductively coupled mass spectrometry
in order to validate the method. Boron-10 isotope measurements were carried out by HR–ICP–MS at medium resolution (R=4000)
due to the presence of an isobaric interference at mass 10. Good agreement was obtained between the values from CE–ESI–MS
and those from HR–ICP–MS. The method has been successfully used to determine the 10B-BPA in two lines of cultured cells. 相似文献
102.
Marco Campo Jose R Fernandez Ramon Quintanilla 《Journal of Applied Analysis & Computation》2019,9(1):332-344
In this paper we analyze, from the numerical point of view, a dynamic thermoelastic problem. Here, the so-called exact heat conduction model with a delay term is used to obtain the heat evolution. Thus, the thermomechanical problem is written as a coupled system of partial differential equations, and its variational formulation leads to a system written in terms of the velocity and the temperature fields. An existence and uniqueness result is recalled. Then, fully discrete approximations are introduced by using the classical finite element method to approximate the spatial variable and the implicit Euler scheme to discretize the time derivatives. A priori error estimates are proved, from which the linear convergence of the algorithm could be derived under suitable additional regularity conditions. Finally, a two-dimensional numerical example is solved to show the accuracy of the approximation and the decay of the discrete energy. 相似文献
103.
Vittorino Pata Ramon Quintanilla 《Journal of Mathematical Analysis and Applications》2010,363(1):19-3605
The decay of solutions in nonsimple elasticity with memory is addressed, analyzing how the decay rate is influenced by the different dissipation mechanisms appearing in the equations. In particular, a first order dissipation is shown to guarantee the asymptotic stability of the related solution semigroup, but is not strong enough to entail exponential stability. The latter occurs for a dissipation mechanism of the second order, that is, the same order as the one of the leading operator. 相似文献
104.
Deka Prismawan Ramon vanderVlag Hao Guo Frank J. Dekker Anna K. H. Hirsch 《Helvetica chimica acta》2019,102(5)
Human 15‐lipoxygenase‐1 (15‐LOX‐1) belongs to the class of lipoxygenases, which catalyze oxygenation of polyunsaturated fatty acids, such as arachidonic and linoleic acid. Recent studies have shown that 15‐LOX‐1 plays an important role in physiological processes linked to several diseases such as airway inflammation disease, coronary artery disease, and several types of cancer such as rectal, colon, breast and prostate cancer. In this study, we aimed to extend the structural diversity of 15‐LOX‐1 inhibitors, starting from the recently identified indolyl core. In order to find new scaffolds, we employed a combinatorial approach using various aromatic aldehydes and an aliphatic hydrazide tail. This scaffold‐hopping study resulted in the identification of the 3‐pyridylring as a suitable replacement of the indolyl core with an inhibitory activity in the micromolar range (IC50=16±6 μm ) and a rapid and efficient structure–activity relationship investigation. 相似文献
105.
Raul F. Velasco César Guerrero Gloria Fra Alejandra Moure Juan Miguel-Siles Maria Teresa Quesada-Campos Jose Ramon Ruiz-Gomez Ian H. Gilbert Michael G. Thomas Timothy J. Miles 《Tetrahedron letters》2019,60(18):1243-1247
During the course of a research program aimed at identifying novel antileishmanial compounds, a multi-gram synthesis of N-(trans-4-((4-methoxy-3-((R)-3-methylmorpholino)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)cyclohexyl)-2-methylpropane-1-sulfonamide ((R)-1) was required. This letter describes optimisation of the reaction conditions and protecting group strategy for a key Buchwald-Hartwig coupling, delivering the required quantities of (R)-1, as well as further compounds in the series. 相似文献
106.
In this study, several simple aspects associated with the periodic table (PT) of the elements are commented. First, the connection of the PT with the structure of a seven-dimensional Boolean hypercube leads afterward to discuss the nature of those PT elements bearing prime atomic numbers. Second, the use of quantum similarity (QS) to obtain an alternative insight on the PT element relations will be also developed. The foundation of the second part starts admitting that any element of the PT can be attached to a schematic electronic density function, constructed with a single Gaussian function: a Gaussian atomic density function, allowing to consider the PT elements as a set of quantum objects, and permits a straightforward construction of a QS matrix. Such QS scheme can be applied to the whole PT or to any subset of it. Manipulation of the QS matrices attached to any quantum object set allows the evaluation of statistical-like values, acting as coordinates to numerically or graphically represent the chosen PT atomic element sets. © 2019 Wiley Periodicals, Inc. 相似文献
107.
108.
109.
Stephan Ramon Garcia 《Integral Equations and Operator Theory》2008,60(3):357-367
If denotes the polar decomposition of a bounded linear operator T, then the Aluthge transform of T is defined to be the operator . In this note we study the relationship between the Aluthge transform and the class of complex symmetric operators (T iscomplex symmetric if there exists a conjugate-linear, isometric involution so that T = CT*C). In this note we prove that: (1) the Aluthge transform of a complex symmetric operator is complex symmetric, (2) if T is complex symmetric, then and are unitarily equivalent, (3) if T is complex symmetric, then if and only if T is normal, (4) if and only if T
2 = 0, and (5) every operator which satisfies T
2 = 0 is necessarily complex symmetric.
This work partially supported by National Science Foundation Grant DMS 0638789. 相似文献
110.
Crovetto L Rios R Alvarez-Pez JM Paredes JM Lozano-Velez P del Valle C Talavera EM 《The journal of physical chemistry. B》2008,112(33):10082-10085
The 2,5-dioxopyrrolidin-1-yl-4-(3-hydroxy-6-oxo-6H-xanthen-9-yl)-3-methylbenzoate has been synthesized as an amine-reactive derivative able to yield stable covalently labeled biopolymers. The new derivative has been used to label polyribocytidilic acid (5'), poly(C), amine residues. TG-II-poly(C) exhibits monoexponential decay at the physiological pH range. In addition, both steady-state fluorescence intensity and fluorescence decay are also sensitive to solution pH. The large decrease in steady-state fluorescence upon hybridization allows it to be used as a nucleic acid probe in a homogeneous assay format. In summary, we report an efficient synthesis to obtain labeled RNA from commercially available materials in excellent yields. 相似文献