Two New C—21 Steroidal Glycosides from Cynanchum aurichulatum

Two new C-21 steroidal glycosides, cynanauriculoside I and cynanauriculoside Ⅱ, were isolated from the roots of Cynanchum aurichulatum. Their structures were established using spectroscopic methods including one and two-dimensional NMR.     

LaxBa1—xCoO3系导电陶瓷导电性研究

对ＬａｘＢａ１－ｘＣｏＯ导电陶瓷的导电性及其导电机制进行了研究，在ｘ＝０．５ｍｏｌ处，导电陶瓷具有金属态导是性，在Ｌａ０．５Ｂａ０．５ＣｏＯ３陶瓷中，存在着氧缺位和导电电子，并且此种导电陶瓷具有较高的电子和氧离子混合导电特性。     

Synthesis and Crystal Structures of Novel Keggin and Dawson Polyoxometalates Containing Amantadine

Heteropolyoxometalates are a large family of potent medicines due to their excellent antiviral and antitumor activity 1-4, while their application in clinic meets great difficulties for their toxicity 5. How to synthesize heteropolyoxometalate medicines possessing high activity and low toxicity has become the focus in heteropolyoxometalate medicine research. Previously reported polyoxometalates showing medical activities are all salts simple Na+, K+ or NH4+ etc. inorganic cations, in which o…     

孔壁部分有序化的介孔二氧化硅材料的合成与表征

采用一种“改进的二次晶化”的方法处理介孔二氧化硅SBA-15. 用X射线衍射(XRD)、 透射电镜(TEM)、 电子衍射(ED)、 红外光谱(FTIR)以及固体核磁共振(NMR)等多种技术对样品进行了表征.　结果表明， 在所得样品的孔壁中, 原子的排列方式与普通介孔二氧化硅材料的孔壁不同， 显示一定程度的有序性. 同时, 高度有序的介孔结构得到很好的保持, 且样品的水热稳定性大幅度提高.     

紫杉醇的合成进展

紫杉醇是一种重要的抗癌药物,它具有复杂新颖的化学结构,为三环二萜类化合物.本文综述了紫杉醇的半合成和紫杉烷环的各种合成方法.     

黄烷类衍生物的合成及其生物活性研究

An efficient and feasible synthetic approach was developed for the synthesis of an array of new flavane derivafives from the substituted benzaldehyde with the reduction of chalcones and subsequent cyclization as the key steps. The purity and structure of the products were confirmed by the elemental analysis and a combination of its IR, ^1H and ^13C NMR, and mass spectra. These synthetic compounds were tested for xanthine oxidase （XO） inhibitions and antifungal actions against Candida albicans, Cryptococcus neoformans, Aspergillus sp. and Trichophyton rubrum. 7-Hydrazinocarbonylmethoxy-4＇-methoxyflavane （9） was found to be the most XO inhibitory with IC50=76.4 μmol/L, and the most potent antifungal compound was 4＇-hydrazinocarbonylmethoxyflavane （12） with minimal inhibition concentration MIC=8 μg/mL against Trichophyton rubrum.     

Study on Extraction Process of Root of Henry Wood Betony Polysaccharides and Their Antitumor Activity against S180

We optimized the hot water extraction of polysaccharides from the root of Henry wood betony (RHWPs) using a uniform test and explored their anti-tumor activities in vitro and in vivo. The optimal extraction conditions were as follows: 40 min extraction time, liquid/solid ratio 30 mL/g, 100 min soaking time, two extraction cycles, 100% ethanol concentration, and extraction temperature of 80 °C. The molecular weight distribution of RHWPs with MWs was 228,600 g/mol and 5001 g/mol. The IR spectrum further indicated that RHWPs are acidic polysaccharides containing pyranose and furan rings. The main monosaccharides found in RHWPs were mannose, ribose, l-rhamnose monohydrate, glucuronic acid, galacturonic acid, glucose, galactose, xylose, arabinose, and fucose. RHWPs inhibited the proliferation of S180 tumor cells and induced apoptosis in vitro. Oral administration of RHWPs to tumor-bearing mice significantly inhibited the growth of the S180 xenografts, accelerated apoptosis in tumor cells, and expanded the necrotic regions. Furthermore, RHWPs also markedly increased the levels of TNF-α, IFN-γ, and IL-2 in the sera of tumor-bearing mice, and activated immune cells such as lymphocytes, NK cells, and macrophages, thereby inducing tumor cell apoptosis. Taken together, RHWPs are a promising anti-tumor agent that ought to be explored further.     

DEHYDROGENATION AND AROMATIZATION OF METHANE IN THE ABSENCE OF OXYGEN OVER DOPED Mo/HZSM-5 CATALYSTS

研究了在Ｍｏ／ＨＺＳＭ－５催化剂上添加助剂以及不同的反应预处理温度对甲烷无氧脱氢芳构化反应的影响。实验结果表明，由于第二组分的添加，Ｍｏ／ＨＺＳＭ－５催化剂的活性和选择性都得到了较大程度的改善。预处理温度是影响催化剂反应性能的关键因素。Ｍｏ－Ｒｕ／ＨＺＳＭ－５催化剂经过８７３Ｋ空气预处理后，甲烷在９７３Ｋ的转化率约为１０％，催化剂的稳定性也得到较大程度的提高。ＴＰＳＲ实验结果表明，Ｒｕ的加入降低了芳烃生成的温度。ＴＰＯ和ＤＴＡ实验结果表明，在Ｍｏ－Ｒｕ／ＨＺＳＭ－５催化剂上可生成较多的碳物种，结合反应结果，可以认为反应过程中生成的碳物种对甲烷的无氧脱氢芳构化反应是起积极作用的     

Composite Electrode SnO2／TiO2 for Dye-Sensitized Solar Cells

Composite nanoporous electrode SnO2/TiO2 was fabricated for the dye sensitized solar cell (DSSC) with N3 (Cis-Ru). After introducing of TiO2, the open-circuit photovoltage (Voc) was higher than that of the pure SnO2 electrode, while short-circuit photocurrent (Isc) was varied with the ratio of the TiO2. Appropriate content of the TiO2 can be beneficial to the efficiency of the solar cell, and it gives negative impact on the composite electrode when the content of TiO2 is higher.     

Micro-Determination of Protein Containing SH– and –S–S– Groups Based on the Polarographic wave of an Electroactive Derivative

This paper presents a new simple and sensitive method for the micro-determination of protein containing SH– and –S–S– groups based on the single sweep polarographic wave of an electroactive derivative. In 0.04molL^–1 Na₃PO₄ and 0.2% ascorbic acid solution, protein is heated in a boiling water bath for 15min, the reaction product giving a sensitive reduction wave at –0.70V (vs. SCE). The wave height is linearly proportional to the concentration of protein. The calibration curves of bovine serum albumin (BSA), human serum albumin (HSA), ovalbumin (OVA) and lysozyme (Lyso) are constructed under the optimal conditions. For BSA and HSA, the linear ranges and detection limits are 0.05–24mgL^–1 and 0.02mgL^–1, respectively. The method has been applied to the determination of protein in human serum samples with satisfactory results. The mechanism of the polarographic wave was also studied, and the results show that S^2– ion is released from the protein molecule during the derivatization reaction, the wave being attributed to the reduction of HgS.