Simultaneous determination of five strobilurin fungicides and the metabolite BF-500-3 in cereals,fruits and vegetables

A rapid and sensitive method for the simultaneous determination of five strobilurin fungicides and the metabolite BF-500-3 in cereals (maize and wheat), fruits (grape and apple) and vegetables (cucumber and tomato) was developed by a Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS) method using high-performance liquid chromatography/tandem mass spectrometry (HPLC-MS/MS). The five strobilurin fungicides (kresoxim-methyl, picoxystrobin, pyraclostrobin, azoxystrobin and trifloxystrobin) and the metabolite BF-500-3 were extracted from six matrices using acetonitrile and subsequently cleaned up by dispersive solid phase extraction (d-SPE) using octadecylsilane (C₁₈) as sorbent prior to HPLC-MS/MS analysis. The determination of the six compounds was achieved in less than 6.0 min using an electrospray ionisation source in positive mode (ESI+). This method showed the linearity with the coefficients of determination (R²) higher than 0.9929. The limits of quantification (LOQs), defined as the lowest spiking level, were 5 μg/kg for all the fungicides in all matrices. Recovery studies were performed at three fortification levels (5, 10 and 100 μg/kg) and the overall average recoveries ranged from 76.9% to 114.2% with the relative standard deviation (RSD) less than 13.6% for all the analytes. The method is demonstrated to be convenient and reliable for the routine monitoring of five strobilurin fungicides and the metabolite BF-500-3 in cereals, fruits and vegetables.     

Air-assisted liquid–liquid microextraction by solidifying the floating organic droplets for the rapid determination of seven fungicide residues in juice samples

A novel air assisted liquid–liquid microextraction using the solidification of a floating organic droplet method (AALLME-SFO) was developed for the rapid and simple determination of seven fungicide residues in juice samples, using the gas chromatography with electron capture detector (GC-ECD). This method combines the advantages of AALLME and dispersive liquid–liquid microextraction based on the solidification of floating organic droplets (DLLME-SFO) for the first time. In this method, a low-density solvent with a melting point near room temperature was used as the extraction solvent, and the emulsion was rapidly formed by pulling in and pushing out the mixture of aqueous sample solution and extraction solvent for ten times repeatedly using a 10-mL glass syringe. After centrifugation, the extractant droplet could be easily collected from the top of the aqueous samples by solidifying it at a temperature lower than the melting point. Under the optimized conditions, good linearities with the correlation coefficients (γ) higher than 0.9959 were obtained and the limits of detection (LOD) varied between 0.02 and 0.25 μg L⁻¹. The proposed method was applied to determine the target fungicides in juice samples and acceptable recoveries ranged from 72.6% to 114.0% with the relative standard deviations (RSDs) of 2.3–13.0% were achieved. Compared with the conventional DLLME method, the newly proposed method will neither require a highly toxic chlorinated solvent for extraction nor an organic dispersive solvent in the application process; hence, it is more environmentally friendly.     

Automated online pretreatment and cleanup recycle coupled with high‐performance liquid chromatography‐mass spectrometry for determination of deca‐bromodiphenyl ether in human serum

Automated online SPE‐HPLC‐MS was established for the determination of deca‐bromodiphenyl ether in human serum. The online SPE with large volume injection was utilized to enhance the sensitivity. Online SPE with dilution line greatly decreased matrices effect, which enabled serum samples to be injected directly into pre‐column. Washing line was designed for the system to solve the serious residual phenomenon and reduce the risk of sample wastage and contamination. Under the optimized conditions, the linear of the method was in the range 0.1–10 ng/mL with the LOD of 0.026 ng/mL. The recoveries of serum samples spiked with deca‐bromodiphenyl ether at 0.5 ng/mL was in the range from 83.30 to 102.7% with RSD in interday less than 8.67%. The satisfactory results demonstrated that the method of online sample pretreatment and cleanup recycle were reliable for human serum analysis.     

A general and efficient synthesis of substituted furans and dihydrofurans via gold-catalyzed cyclization of (Z)-2-en-4-yn-1-ols

A highly efficient Au-catalyzed cyclization of (Z)-enynols that proceeds under mild reaction conditions has been developed. This methodology provides rapid access to substituted furans and stereodefined (Z)-5-ylidene-2,5-dihydrofurans in a regioselective manner from suitably substituted (Z)-2-en-4-yn-1-ols.     

Birkhoff力学的研究进展

Birkhoff力学是Hamilton力学的一个自然发展,是分析力学发展的一个新阶段,它广泛应用于力学、物理学和工程.本文总结Birkhoff力学的形成和发展,特别是近二十年所取得的成就.首先,从Birkhoff的《动力系统》中的有关段落开始,叙述Birkhoff力学的起源.其次,叙述这个力学的基本原理——Pfaff-Birkhoff原理以及这个力学的基本方程——Birkhoff方程的形成和发展.第三,简述Birkhoff力学的一些专门问题,包括约束Birkhoff系统,Birkhoff方程的积分方法,Birkhoff动力学逆问题,Birkhoff方程的运动稳定性,Birkhoff系统的几何方法,Birkhoff系统的全局分析等.最后,对Birkhoff力学的未来研究提出一些建议.      

An efficient and practical asymmetric synthesis of (−)-tasimelteon

Tasimelteon is a useful drug for the treatment of Non-24 in totally blind individuals. An efficient and convenient asymmetric synthesis of tasimelteon has been developed from 4-vinyl-2,3-dihydrobenzofuran through six steps in 53% overall yield using the Corey–Bakshi–Shibata (CBS0 asymmetric reduction of ketone as a key step.     

Ranking the spreading influence of nodes in complex networks: An extended weighted degree centrality based on a remaining minimum degree decomposition

Ranking the spreading influence of nodes is crucial for developing strategies to control the spreading process on complex networks. In this letter, we define, for the first time, a remaining minimum degree (RMD) decomposition by removing the node(s) with the minimum degree iteratively. Based on the RMD decomposition, a weighted degree (WD) is presented by utilizing the RMD indices of the nearest neighbors of a node. WD assigns a weight to each degree of this node, which can distinguish the contribution of each degree to the spreading influence. Further, an extended weighted degree (EWD) centrality is proposed by extending the WD of the nearest neighbors of a node. Assuming that the spreading process on networks follows the Susceptible-Infectious-Recovered (SIR) model, we perform extensive experiments on a series of synthetic and real networks to comprehensively evaluate the performance of EWD and other eleven representative measures. The experimental results show that EWD is a relatively efficient measure in running efficiency, it exposes an advantage in accuracy in the networks with a relatively small degree heterogeneity, as well as exposes a competitive performance in resolution.     

判定非自治Birkhoff系统稳定性的广义组合梯度方法

研究判定非自治Birkhoff系统稳定性的广义组合梯度方法．首先,给出非自治Birkhoff系统和非自治广义Birkhoff系统的运动微分方程;其次,给出一类将广义梯度系统和广义斜梯度系统组合而成的广义组合梯度系统,并讨论广义组合梯度系统的一些性质;最后,将非自治Birkhoff系统和非自治广义Birkhoff系统在一定条件下表示成广义组合梯度系统,并用广义组合梯度系统的性质研究了这两类Birkhoff系统的稳定性．举例说明结果的应用．     

流体饱和两相多孔介质拟静态问题的有限元解法

给出基于混合物理论的流体饱和两相多孔介质模型,该模型由一可变形固体 一流体相组成。采用Ｇａｌｅｒｋｉｎ加权残值法导出求解拟静态问题的有限元公式,并编制了二维有限元程序。用程序分析了一维和二维问题,得到合理的结果。     

Algebraic structures and poisson integrals of relativistic dynamical equations for rotational systems

Ｉｎ１９７９,Ｒ．ＢｅｎｇｔｓｓｏｎａｎｄＳ．Ｆｒａｕｅｎｄｏｒｆａｃｃｕｒａｔｌｙｍｅａｓｕｒｅｄｔｈｅｍａｘｉｍｕｍｖａｌｕｅｓｏｆｔｈｅｓｐｉｎｖｅｌｏｃｉｔｙｏｆ１４ｋｉｎｄｓｏｆｎｕｃｌｅｏｎｓ,ａｎｄｒｅｓｕｌｔｓｓｈｏｗｅｄｔｈｅｍａｘｉｍｕｍｖａｌｕｅｏｆｔｈｅｓｐｉｎｖｅｌｏｃｉｔｙｏｆｅａｃｈｎｕｃｌｅｏｎｗａｓｄｉｆｆｅｒｅｎｔｔｏａｎｏｔｈｅｒｓ［１］．Ｗｉｔｈｔｈｅｄｅｖｅｌｏｐｍｅｎｔｏｆｓｃｉｅｎｃｅａｎｄｔｅｃｈｎｏｌｏｇｙ,ｍｏｒｅａｎｄｍｏｒｅｅｘｐｅｒｉｍｅ…