Spatial condensation of trapped polaritons in graphene and semiconductor structures

The theoretical and experimental status of the Bose–Einstein Condensation (BEC) of trapped quantum well (QW) polaritons in a microcavity is presented. The results of recent experiments that have shown the possibility to create an in-plane harmonic potential trap for a two-dimensional (2D) exciton polaritons in a cavity are discussed. We report the theory of BEC and of the trapped QW exciton polaritons in a microcavity. In addition, we study the BEC of trapped magnetoexciton polaritons in a graphene layer (GL) embedded in an optical microcavity in high magnetic field. In both cases the polaritons are considered to be in a harmonic potential trap. We compare the theoretical results with the existing experiments and discuss the experimental observation of predicted phenomena.     

Eine chemische Reaction auf Cholerabakterien

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The principle of virtual work in mechanical and electromechanical systems

Summary The principle of virtual work is applied to electromechanical systems as the foundation of a unifying concept for modelling mechatronical systems. After the presentation of an important result in the field of mechanics, the expansion of the principle on electrical networks and electromechanical systems is shown. The use of the principle of virtual work in the domain of electromechanics yields an analogous form to the central equation of mechanics which is valid for holonomic and nonholonomic systems. The electrotechnical part of the system is confined to networks. The derivation of the mathematical model is demonstrated on the example of a simple electromechanical oscillation circuit. In addition, the physical systems are separately treated, taking into account the explicit constraints on the basis of the Lagrangian multiplier method.     

Fragment‐Based De Novo Design Reveals a Small‐Molecule Inhibitor of Helicobacter Pylori HtrA

Sustained identification of innovative chemical entities is key for the success of chemical biology and drug discovery. We report the fragment‐based, computer‐assisted de novo design of a small molecule inhibiting Helicobacter pylori HtrA protease. Molecular binding of the designed compound to HtrA was confirmed through biophysical methods, supporting its functional activity in vitro. Hit expansion led to the identification of the currently best‐in‐class HtrA inhibitor. The results obtained reinforce the validity of ligand‐based de novo design and binding‐kinetics‐guided optimization for the efficient discovery of pioneering lead structures and prototyping drug‐like chemical probes with tailored bioactivity.