Quantification of complanatoside A in rat plasma using LC‐MS/MS and its application to a pharmacokinetic study

Complanatoside A is a flavonol glycoside isolated from Astragalus complanatus, and currently it is used as a quality control index for A. complanatus in the 2010 edition of the Chinese Pharmacopoeia. For the first time, a simple and sensitive LC‐MS/MS method was developed for the determination of complanatoside A in rat plasma over the range of 2.3–575 ng/mL. Complanatoside A was extracted from plasma by a protein precipitation procedure, separated by LC and detected by MS/MS in positive electrospray ionization mode. The method was validated for selectivity, carryover, sensitivity, linearity, extraction recovery, matrix effect, accuracy, precision and stability studies. The lower limit of quantification was established at 2.3 ng/mL. Intra‐ and inter‐day precisions (LLOQ, low‐QC, med‐QC and high‐QC) were <7.9%, and accuracies were between 94.0 and 105.1%. Matrix effect was acceptable (97.9–103.0%) and extraction recovery was reproducible (88.5–94.4%). Complanatoside A was stable in the investigated conditions. The method was applied to the pharmacokinetics of complanatoside A in rats. Copyright © 2015 John Wiley & Sons, Ltd.     

A Fractal Representation of the Complex Clifford Algebra Equivalent to the Fock Representation

We construct a representation of the infinite dimensional complex Clifford algebra on the Hilbert space of square-integrable complex-valued functions on the Cantor set, which we show to be equivalent to the classical Fock representation.     

Does Euclidean distance work well when the p-median model is applied in rural areas?

The p-median model is used to locate P centers to serve a geographically distributed population. A cornerstone of such a model is the measure of distance between a service center and demand points, i.e. the location of the population (customers, pupils, patients, and so on). Evidence supports the current practice of using Euclidean distance. However, we find that the location of multiple hospitals in a rural region of Sweden with a non-symmetrically distributed population is quite sensitive to distance measure, and somewhat sensitive to spatial aggregation of demand points.     

Dynamical behaviour of multi-particle large-scale systems

Collective behaviours can be observed in both natural and man-made systems composed of a large number of elemental subsystems. Typically, each elemental subsystem has its own dynamics but, whenever interaction between individuals occurs, the individual behaviours tend to be relaxed, and collective behaviours emerge. In this paper, the collective behaviour of a large-scale system composed of several coupled elemental particles is analysed. The dynamics of the particles are governed by the same type of equations but having different parameter values and initial conditions. Coupling between particles is based on statistical feedback, which means that each particle is affected by the average behaviour of its neighbours. It is shown that the global system may unveil several types of collective behaviours, corresponding to partial synchronisation, characterised by the existence of several clusters of synchronised subsystems, and global synchronisation between particles, where all the elemental particles synchronise completely.     

Theoretical analysis of discrete contact problems with Coulomb friction

A discrete model of the two-dimensional Signorini problem with Coulomb friction and a coefficient of friction F depending on the spatial variable is analysed. It is shown that a solution exists for any F and is globally unique if F is sufficiently small. The Lipschitz continuity of this unique solution as a function of F as well as a function of the load vector f is obtained. Furthermore, local uniqueness of solutions for arbitrary F > 0 is studied. The question of existence of locally Lipschitz-continuous branches of solutions with respect to the coefficient F is converted to the question of existence of locally Lipschitz-continuous branches of solutions with respect to the load vector f. A condition guaranteeing the existence of locally Lipschitz-continuous branches of solutions in the latter case and results for determining their directional derivatives are given. Finally, the general approach is illustrated on an elementary example, whose solutions are calculated exactly.     

Diffusion of biostimulators into plant tissues

Biostimulators are substances able to enhance the immune system of cultivated crops and support plant metabolism. Their utilization helps to reduce the amount of chemicals used in agriculture. To perform the desired effect, a biostimulator must be able to penetrate into the plant tissue. The time of penetration however, is limited, since the biostimulator must remain in a liquid state. This is of great importance—especially in field conditions, where the treated plants are exposed to different weather condition and other extrinsic factors. A mathematical model based on diffusion mechanisms has been elaborated to describe the biostimulator transport process from penetration of the leaves into the plant’s inner tissues. By means of the effective diffusion coefficient of the prepared specific protein hydrolyzate, this model can be used to estimate the time necessary for the uptake of the minimal active amount of the biostimulator.     

Spectral manifestation of collective plasma oscillations quasi-resonant to eigenfrequencies of individual nanoparticles in a silver Island film

A doublet is revealed in the light extinction spectrum of a thin silver island film and the explanation of its nature is proposed. Based on the electron microscopy data, it is found that the doublet cannot be formed only by intrinsic resonances of individual islands. Because of interisland interactions, light can excite collective fields localized near the film. Resonant frequencies of these localized modes depend on the size, concentration, and arrangement of individual islands, whose plasma oscillation frequencies differ only slightly from one another.     

Off-resonance frequency filtered magnetic resonance imaging

One of the main problems with rapid magnetic resonance imaging (MRI) techniques is the artifacts that result from off-resonance effects. The proposed off-resonance frequency filtered MRI (OFF-MRI) method focuses on the elimination of off-resonance components from the image of the observed object. To maintain imaging speed and simultaneously achieve good frequency selectivity, MRI is divided into two steps: signal acquisition and post-processing.