Amorphous Carbon Film with Self-modified Carbon Nanoparticles Synthesized by Low Temperature Carbonization of Phenolic Resin for Simultaneous Sensing of Dopamine and Uric Acid

A self-modified film electrode consisting of homogeneous snowflake-shaped nanoparticles on the amorphous carbon substrate (HNAC) was prepared by low temperature carbonization of phenolic resin. Such a unique structure was beneficial to enhance the electroanalysis signal responds. Simultaneous detection of DA and UA was performed on the HNAC using differential pulse voltammetry (DPV) at pH 8 phosphate buffer. The well-defined oxidation peak potential separation reached 260 mV between DA and UA. Meanwhile, the detection limit of HNAC were 0.401 μM (DA) and 2.800 μM (UA).     

Growth and optical properties of Pr<Superscript>3+</Superscript>:KLu(WO<Subscript>4</Subscript>)<Subscript>2</Subscript> laser crystal: a candidate for red emission laser

A Pr³⁺:KLu(WO₄)₂ crystal with dimension of 30 × 30 × 15 mm³ was grown in the K₂W₂O₇ flux. A slice was cut from the crystal, and the polarized absorption and fluorescence spectra were measured at room temperature. Based on the J-O theory, the oscillator intensity parameters Ω _t (t = 2, 4, 6), spontaneous emission probabilities and branch ratios were estimated and good results had been obtained. Furthermore, the crystal has a relatively large emission cross-section in the region of 615–630 nm with the highest value of 14.5 × 10^?20 cm², which indicates that the crystal is good for the application in red emission laser. The emission decay time for ¹D₂ and ³P₀ multiplets was discussed. By adapting the I-H model to fit the emission decay curves, the lifetime for ¹D₂ at 607 nm and ³P₀ at 615 nm are 19.72 μs and 8.95 μs, respectively. Then the corresponding fluorescence quantum efficiencies of the two multiplets reach 83.7 % and 87.9 %, respectively. All the studies illustrate that this crystal is potential in red emission laser application.     

Adaptive registration of diffusion tensor images on lie groups

With diffusion tensor imaging (DTI), more exquisite information on tissue microstructure is provided for medical image processing. In this paper, we present a locally adaptive topology preserving method for DTI registration on Lie groups. The method aims to obtain more plausible diffeomorphisms for spatial transformations via accurate approximation for the local tangent space on the Lie group manifold. In order to capture an exact geometric structure of the Lie group, the local linear approximation is efficiently optimized by using the adaptive selection of the local neighborhood sizes on the given set of data points. Furthermore, numerical comparative experiments are conducted on both synthetic data and real DTI data to demonstrate that the proposed method yields a higher degree of topology preservation on a dense deformation tensor field while improving the registration accuracy.     

硅单粒子位移损伤多尺度模拟研究

本文结合分子动力学方法和动力学蒙特卡罗方法, 研究了单个粒子入射硅引起的位移损伤缺陷的产生和演化过程; 基于Shockley-Read-Hall理论计算了单个粒子入射引起的位移损伤缺陷导致的泄漏电流增加及其演化过程, 比较了缺陷退火因子与泄漏电流退火因子之间的差异, 并将计算结果与实验值进行了对比. 结果表明, 计算泄漏电流时, 仅考虑一种缺陷的情况下缺陷退火因子与泄漏电流退火因子相同, 考虑两种缺陷类型情况下二者在数值上有所区别, 但缺陷退火因子仍能在一定程度上反映泄漏电流的退火行为. 分子动力学模拟中采用Stillinger-Weber势函数和Tersoff势函数时缺陷退火因子和泄漏电流退火因子与实验结果一致, 基于Stillinger-Weber势函数的计算结果与实验值更为接近.     

High-throughput screening against $$\sim $$6.1 million structurally diverse,lead-like compounds to discover novel ROCK inhibitors for cerebral injury recovery

Rho-associated protein kinase (ROCK) has been recognized as an attractive therapeutic target to promote neurogenesis, neuroregeneration, and neurorecovery after cerebral injury. Here, a high-throughput screening protocol was described to discover novel ROCK inhibitors from a large chemical library containing \(\sim \)6.1 million structurally diverse, lead-like compounds. The protocol employed empirical rules such as ADMET evaluation and chemical similarity analysis to exclude those of drug-unlike candidates, and then molecular docking and binding affinity predictions were performed to suggest few promising candidates with high scores. Consequently, five compounds were successfully identified to have satisfactory activity profile with \(\hbox {IC}_{50}\) values at nanomolar level. In order to elucidate the molecular mechanism of inhibitor binding to target, the complex structures of ROCK kinase domain with the five identified compounds were modeled and examined in detail. A number of polar chemical forces such as hydrogen bonds and cation-\(\pi \) interactions as well as nonpolar contacts such as \(\pi \)–\(\pi \) stacking and hydrophobic forces were revealed at the complex interface, conferring high affinity and strong specificity to inhibitor binding. In addition, several key residues around the kinase active site, including Val90, Lys105, Asn203, and Phe368, were found to play an important role in binding.     

Observation of two resonant structures in e+ e- -->pi+ pi- psi(2S) via initial-state radiation at Belle

The cross section for e+ e- --> pi+ pi- psi(2S) between threshold and sqrt[s]=5.5 GeV is measured using 673 fb(-1) of data on and off the Upsilon(4S) resonance collected with the Belle detector at KEKB. Two resonant structures are observed in the pi+ pi- psi(2S) invariant-mass distribution, one at 4361 +/- 9 +/- 9 MeV/c2 with a width of 74 +/- 15 +/- 10 MeV/c2, and another at 4664 +/- 11 +/- 5 MeV/c2 with a width of 48 +/- 15 +/- 3 MeV/c2, if the mass spectrum is parametrized with the coherent sum of two Breit-Wigner functions. These values do not match those of any of the known charmonium states.     

Metallic state in cubic FeGe beyond its quantum phase transition

We report on results of electrical resistivity and structural investigations on the cubic modification of FeGe under high pressure. The long-wavelength helical order (T(C) = 280 K) is suppressed at a critical pressure p(c) approximately 19 GPa. An anomaly at T(X)(p) and strong deviations from a Fermi-liquid behavior in a wide pressure range above p(c) suggest that the suppression of T(C) disagrees with the standard notion of a quantum critical phase transition. The metallic ground state persisting at high pressure can be described by band-structure calculations if zero-point motion is included. The shortest FeGe interatomic distance display discontinuous changes in the pressure dependence close to the T(C)(p) phase line.     

A realization of digital wireless transmission for MRI signals based on 802.11b

In this paper, a digital wireless transmission system based on 802.11b standard for magnetic resonance imaging (MRI) application is designed and built for the first time to eliminate the interference aroused by coil array cables. The analysis shows that the wireless receiver has a very high sensitivity to detect MRI signals. The modulation technique of differential quadrature phase shift keyed (DQPSK) can be applied to MRI data transmission with rate of 2 Mbps and bandwidth of 2 MHz. The bench test verifies that this wireless link has a dynamic range over 86 dB supporting up to 3 T MRI system data transmission. The 2D spin echo imaging of phantom is performed and the SNR of the image obtained by the wireless transmission can be comparable with that got by the coaxial cables.