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51.
Chong Han Sean M. Kelly Theresa Cravillion Scott J. Savage Tina Nguyen Francis Gosselin 《Tetrahedron》2019,75(32):4351-4357
An efficient synthesis of PI3K inhibitor GDC-0077, featuring two consecutive Cu-catalyzed CN coupling reactions, is reported. The described synthetic route involves a chemoselective Ullmann-type coupling of a chiral difluoromethyl-substituted oxazolidinone, a Cu-catalyzed N-arylation of l-alanine with high stereochemical integrity, and a high-yielding final amide bond formation step to produce GDC-0077 in >99.5 area % HPLC purity. 相似文献
52.
Two new spirostanol glycosides named agamenoside A and B, ere isolated from the fermented leaves of Agave americana. Their structures were elucidated as (23S,25R)-5α-spirostan-3β,6α,23-triol 3-O-α-L-rhamnopyranosyl-(1→3)-β-D-glucopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→3)]-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside(1) and (25R)-5α-spiro-stan-3β,6α-diol 3-O-β-D-glucopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→3)]-β-D-glucopyra-nosyl-(1→4)-β-D-galactopyranoside(2) by a combination of chemical and spectral methods. 相似文献
53.
F. Chong Tho L. Natova D. Ruschev 《Journal of Thermal Analysis and Calorimetry》1991,37(11-12):2723-2727
Eugenol and isoeugenol were investigated by means of thermal analysis. It was observed that eugenol and isoeugenol have one characteristic endothermic effect at 260° and 290°C, respectively, and two exothermic effects in the temperature intervals 270°–590°C. The DTA curves of the benzoyl esters of eugenol and isoeugenol begin with endothermic effects at 70° and 95°C, respectively, which coincide with the melting points of these compounds. 相似文献
54.
α-甲基丙烯酸烯丙酯的合成及其自由基、阴离子聚合的研究 总被引:1,自引:0,他引:1
合成了α-甲基丙烯酸烯丙酯(AMA),并对其自由基、阴离子聚合进行了探讨。结果发现,该单体难以进行选择性自由基聚合,但可用作多种单体自由基聚合的交联剂。用1,1′-二苯基己基锂在THF中引发AMA,可顺利地进行α位双键的选择性阴离子聚合,分子量实测值与计算值基本一致。在较低温度下(≤-60℃),可得窄分布PAMA(Mw/Mn=1.12~1.15)。随聚合温度升高,间同和无规聚合物含量分别呈下降和上升趋势。GPC、1HNMR及FTIR鉴定表明,用阴离子聚合法可得到溶于多种溶剂、每个重复单元上均定量带有烯丙基双键的窄分布官能性PAMA。 相似文献
55.
Zachary M. Schulte Yeon Hye Kwon Yi Han Chong Liu Lin Li Yahui Yang Austin Gamble Jarvi Sunil Saxena Gtz Veser J. Karl Johnson Nathaniel L. Rosi 《Chemical science》2020,11(47):12807
Metal–organic frameworks constructed from multiple (≥3) components often exhibit dramatically increased structural complexity compared to their 2 component (1 metal, 1 linker) counterparts, such as multiple chemically unique pore environments and a plurality of diverse molecular diffusion pathways. This inherent complexity can be advantageous for gas separation applications. Here, we report two isoreticular multicomponent MOFs, bMOF-200 (4 components; Cu, Zn, adeninate, pyrazolate) and bMOF-201 (3 components; Zn, adeninate, pyrazolate). We describe their structures, which contain 3 unique interconnected pore environments, and we use Kohn–Sham density functional theory (DFT) along with the climbing image nudged elastic band (CI-NEB) method to predict potential H2/CO2 separation ability of bMOF-200. We examine the H2/CO2 separation performance using both column breakthrough and membrane permeation studies. bMOF-200 membranes exhibit a H2/CO2 separation factor of 7.9. The pore space of bMOF-201 is significantly different than bMOF-200, and one molecular diffusion pathway is occluded by coordinating charge-balancing formate and acetate anions. A consequence of this structural difference is reduced permeability to both H2 and CO2 and a significantly improved H2/CO2 separation factor of 22.2 compared to bMOF-200, which makes bMOF-201 membranes competitive with some of the best performing MOF membranes in terms of H2/CO2 separations.Tailorable multicomponent MOFs and MOF membranes for efficient H2/CO2 separation. 相似文献
56.
Jiang‐Tao Chen Hai‐Zhou Li Dong Wang Ying‐Jun Zhang Chong‐Ren Yang 《Helvetica chimica acta》2006,89(7):1442-1448
Three new dammarane monodesmosides, named notoginsenosides Ft1 ( 1 ), Ft2 ( 2 ), and Ft3 ( 3 ), together with three known ginsenosides, were obtained from a mild acidic hydrolysis of the saponins from notoginseng (Panax notoginseng (Burk .) F. H. Chen ) leaves. Their structures were elucidated to be (3β,12β,20R)‐12,20‐dihydroxydammar‐24‐en‐3‐yl O‐β‐D ‐xylopyranosyl‐(1 → 2)‐O‐β‐D ‐glucopyranosyl‐(1 → 2)‐β‐D ‐glucopyranoside ( 1 ), (3β,12β)‐12,20,25‐trihydroxydammaran‐3‐yl O‐β‐D ‐xylopyranosyl‐(1 → 2)‐O‐β‐D ‐glucopyranosyl‐(1 → 2)‐β‐D ‐glucopyranoside ( 2 ), and (3β,12β,24ξ)‐12,20,24‐trihydroxydammar‐25‐en‐3‐yl O‐β‐D ‐xylopyranosyl‐(1 → 2)‐O‐β‐D ‐glucopyranosyl‐(1 → 2)‐β‐D ‐glucopyranoside ( 3 ), by means of spectroscopic evidences. The known ginsenosides Rh2 and Rg3 4 – 6 were obtained as the major products from this acidic deglycosylation. 相似文献
57.
Mixing enhancement has drawn great attention from designers of micromixers, since the flow in a microchannel is usually characterized by a low Reynolds number (Re) which makes the mixing quite a difficult task to accomplish. In this paper, a novel integrated efficient micromixer named serpentine laminating micromixer (SLM) has been designed, simulated, fabricated and fully characterized. In the SLM, a high level of efficient mixing can be achieved by combining two general chaotic mixing mechanisms: splitting/recombination and chaotic advection. The splitting and recombination (in other terms, lamination) mechanism is obtained by the successive arrangement of "F"-shape mixing units in two layers. The advection is induced by the overall three-dimensional serpentine path of the microchannel. The SLM was realized by SU-8 photolithography, nickel electroplating, injection molding and thermal bonding. Mixing performance of the SLM was fully characterized numerically and experimentally. The numerical mixing simulations show that the advection acts favorably to realize the ideal vertical lamination of fluid flow. The mixing experiments based on an average mixing color intensity change of phenolphthalein show a high level of mixing performance was obtained with the SLM. Numerical and experimental results confirm that efficient mixing is successfully achieved from the SLM over the wide range of Re. Due to the simple and mass producible geometry of the efficient micromixer, SLM proposed in this study, the SLM can be easily applied to integrated microfluidic systems, such as micro-total-analysis-systems or lab-on-a-chip systems. 相似文献
58.
Thiam Seong Chong 《Journal of organometallic chemistry》2005,690(18):4132-4138
Three methods of obtaining time-resolved Fourier-Transform infrared (TR-FTIR) absorption spectra of transition metal carbonyl radicals in hexane are reported here. For the first method, CpM(CO)2L and Cp*M(CO)2L (M = Mo, W; L = CO, PR3) radicals have been generated by photodissociation of the corresponding metal-metal bonded dimers. Radicals of formula M(CO)4L (M = Mn, Re; L = CO, PR3, AsPh3, SbPh3) and CpM(CO)n (M = Fe, Mo; n = 2, 3) have been produced via the second method which is halogen abstraction of the transition metal carbonyl halides using CpMo(CO)3 radical. For the third method, fast radical ligand substitution kinetics has been exploited to generate CpMo(CO)2PR3 radicals from CpMo(CO)3 in the presence of free phosphines. An assessment of the three methods with respect to TR-FTIR spectroscopic detection of radicals was also discussed. 相似文献
59.
Delano P. Chong 《中国化学会会志》1992,39(5):457-459
The vertical ionization potentials of OF2, HNF2, and CH2F2 were computed by the deMon density functional program. The results are compared with earlier calculations and with experiment. The average absolute deviation of the 21 computed ionization potentials of the outer valence electrons from experiment is 0.44 eV, which compares well with 0.37 eV for frozen-orbital configuration-interaction calculations. Although this performance is not as good as perturbation corrections to Koopmans' theorem, the computation requirements are much less demanding. 相似文献
60.
Ogawa AK DeMattei JA Scarlato GR Tellew JE Chong LS Armstrong RW 《The Journal of organic chemistry》1996,61(18):6153-6161
We report our synthesis of the C(26)-C(37) fragment of serine/threonine protein phosphatase PP1 and PP2A inhibitor calyculin C (1). Outlined in this paper are synthetic approaches to the two components based on disconnection at the C(33)-N(3) amide bond. We report the successful synthesis of the C(33)-C(37) aza-sugar derived from D-lyxose which was coupled onto a C(26)-C(32) aminooxazole originating from L-pyroglutamic acid. Elaboration of the resulting amide to a fully deprotected C(26)-C(37) fragment of calyculin C completed our synthesis. This provided an appropriate phosphonium salt for use in a Wittig olefination for joining both halves of the natural product. 相似文献