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排序方式: 共有199条查询结果,搜索用时 203 毫秒
71.
Dr. Stéphanie Norsikian Dr. Cedric Tresse Dr. Marc François-Eude Dr. Louis Jeanne-Julien Dr. Guillaume Masson Vincent Servajean Dr. Grégory Genta-Jouve Prof. Jean-Marie Beau Dr. Emmanuel Roulland 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(16):6674-6678
A total synthesis of tiacumicin B, a natural macrolide whose remarkable antibiotic properties are used to treat severe intestinal infections, is reported. The strategy is in part based on the prior synthesis of the tiacumicin B aglycone, and on the decisive use of sulfoxides as anomeric leaving groups in hydrogen-bond-mediated aglycone delivery (HAD). This new HAD variant permitted highly β-selective rhamnosylation and noviosylation. To increase convergence, the rhamnosylated C1–C3 fragment thus obtained was anchored to the C4–C19 aglycone fragment by adapting the Suzuki–Miyaura cross-coupling used for the aglycone synthesis. Ring-size-selective macrolactonization provided a compound engaged directly in the noviolysation step with virtually total β selectivity. The final efficient removal of all the protecting groups provided synthetic tiacumicin B. 相似文献
72.
Ayers S Graf TN Adcock AF Kroll DJ Shen Q Swanson SM Wani MC Darveaux BA Pearce CJ Oberlies NH 《Tetrahedron letters》2011,52(40):5128-5130
A fungal extract (MSX 63619), from the Mycosynthetix library of over 50,000 fungi, displayed promising cytotoxicity against a human tumor cell panel. Bioactivity-directed fractionation led to the isolation of an o-pyranonaphthoquinone decaketide, which we termed obionin B (1). The structure of 1 was deduced via spectroscopic and spectrometric techniques. The IC50 value of 1 was moderate, ranging from 3 to 13 μM, depending on the cell line tested. 相似文献
73.
Malvolti F Rouxel C Mongin O Hapiot P Toupet L Blanchard-Desce M Paul F 《Dalton transactions (Cambridge, England : 2003)》2011,40(25):6616-6618
We report in this communication the study of the intramolecular electron transfer through a 2,7-diethynylfluorenyl spacer in the Fe(II)/Fe(III) mixed-valent (MV) complex [(η(2)-dppe)(η(5)-C(5)Me(5))FeC≡C(2,7-C(21)H(24))C≡CFe(η(5)-C(5)Me(5))(η(2)-dppe)][PF(6)] (1[PF(6)]). The complex is generated in situ by comproportionation from its homovalent dinuclear Fe(II) and Fe(III) parents (1 and 1[PF(6)](2)). It is shown that electronic delocalization is much more effective through a 2,7-fluorenyl than through a 4,4'-biphenyl bridging unit. 相似文献
74.
Popovici J Bertrand C Jacquemoud D Bellvert F Fernandez MP Comte G Piola F 《Molecules (Basel, Switzerland)》2011,16(3):2323-2333
We report the identification of the allelochemical 3-(1-oxo-3-phenylpropyl)-1,1,5-trimethylcyclo-hexane-2,4,6-trione, known as myrigalone A, from the fruits and leaves of Myrica gale. The structure of the compound was confirmed by high-resolution techniques (UV, MS and NMR analysis). The compound is phytotoxic towards classical plant species used for allelochemical assays and also against Fallopia x bohemica, a highly invasive plant. Application of either powdered dry leaves or dry fruits of M. gale also showed in vitro phytotoxic activity. We hypothesize that M. gale could be used as a green allelopathic shield to control Fallopia x bohemica invasion, in addition to its potential use as an environmentally friendly herbicide. 相似文献
75.
Dr. Cosima Dufour Dr. Joachim Wink Dr. Michael Kurz Dr. Herbert Kogler Helene Olivan Serge Sablé Winfried Heyse Dr. Martin Gerlitz Dr. Luigi Toti Antje Nußer Dr. Astrid Rey Dr. Cedric Couturier Dr. Armin Bauer Dr. Mark Brönstrup 《Chemistry (Weinheim an der Bergstrasse, Germany)》2012,18(50):16123-16128
In an antibiotic lead discovery program, the known strain Streptomyces armeniacus DSM19369 has been found to produce three new natural products when cultivated on a malt‐containing medium. The challenging structural elucidation of the isolated compounds was achieved by using three independent methods, that is, chemical degradation followed by NMR spectroscopy, a computer‐assisted structure prediction algorithm, and X‐ray crystallography. The compounds, named armeniaspirol A–C ( 2 – 4 ), exhibit a compact, hitherto unprecedented chlorinated spiro[4.4]non‐8‐ene scaffold. Labeling experiments with [1‐13C] acetate, [1,2‐13C2] acetate, and [U‐13C] proline suggest a biosynthesis through a rare two‐chain mechanism. Armeniaspirols displayed moderate to high in vitro activities against Gram‐positive pathogens such as methicillin‐resistant S. aureus (MRSA) or vancomycin resistant E. faecium (VRE). As analogue 2 was active in vivo in an MRSA sepsis model, and showed no development of resistance in a serial passaging experiment, it represents a new antibiotic lead structure. 相似文献
76.
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78.
Summary An investigation has been made of transparent oil-water dispersions stabilized by amphiphilic polymeric substances. The samples are well-defined polyethylene oxide — polystyrene graft copolymers with various lengths of backbone and side chains. The domain for existence of microemulsions and the phase diagrams were determined turbidimetrically by titration with 2-propanol for water/toluene/graft copolymer systems. Results are generalized to several amphilic copolymers of different chemical structure using various polar oils. A behavior markedly different is observed depending on whether soaps or copolymers are used for these systems. In particular, polymeric microemulsions form only when there is a mutual solubility for the ternary solvent mixture. A simple model is proposed, based on particles which consist of two concentric spheres having a PS part solvated by toluene and a PEO part by water, the continuous medium being composed of the ternary solvent mixture at mutual solubility. The size of the particles was determined by light scattering spectroscopy.
With 7 figures and 5 tables 相似文献
Zusammenfassung Transparente, durch amphiphile Polymere stabilisierte Öl-Wasserstreuungen wurden untersucht. Die Proben bestehen aus modellartigen Polyäthylenoxyd-Polystyrol-Pfropfcopolymeren mit verschiedenen Haupt- und Seitenkettenlängen. Wir haben den Bereich der Mikroemulsionbildung und die Phasendiagramme durch Titration der Wasser/Toluol/Pfropfcopolymeren mit 2-Propanol bestimmt. Die allgemeine Gültigkeit der Ergebnisse wurde an mehreren amphiphilen Copolymeren mit verschiedenen chemischen Zusammensetzungen und in verschiedenen Ölen probiert. Ganz verschiedenes Verhalten wurde festgestellt —je nachdem ob Seifen oder Copolymere angewendet wurden. Insbesondere bilden sich Polymermikroemulsionen nur, wenn eine gegenseitige Löslichkeit in den ternären Mischsystemen besteht. Ein einfaches Modell aus zwei konzentrischen Kugeln wird vorgeschlagen: Die eine Kugel besteht aus toluolgequollenem Polystyrol, die andere aus wassergequollenem Polyäthylenoxyd. Die kontinuierliche Phase wird dargestellt durch das ternäre Lösungsmittelsystem. Die Partikelgrößen wurden mit Lichtstreuung bestimmt.
With 7 figures and 5 tables 相似文献
79.
Mezzenga R Grigorov M Zhang Z Servais C Sagalowicz L Romoscanu AI Khanna V Meyer C 《Langmuir : the ACS journal of surfaces and colloids》2005,21(14):6165-6169
We report on the order-to-order transitions of lyotropic liquid crystals formed by self-assembled monogylcerides and water in the presence of polysaccharides of various molecular weights. The phase diagram of monoglyceride-water-polysaccharide systems, their morphology, and the topology of liquid crystalline structures were determined by combining optical cross-polarization, oscillatory shear rheometry, and small-angle X-ray scattering. The presence of hydrophilic mono-, oligo-, and polysaccharides in the water domains of liquid crystalline phases resulted in a general decrease of the cubic-to-hexagonal transition temperature. Provided that the sugar could fit within the water channels, the decrease was observed to be dependent on the polysaccharide concentration but independent of its molecular weight. For isotropic bicontinuous cubic phases, monomeric sugars such as glucose were reported to shrink the lattice parameter of the structure without inducing phase transitions. However, when a polymeric form of glucose was used, such as dextran, transitions from the gyroidal Ia3d cubic phase to double diamond Pn3m cubic phases were observed at well-defined molecular weights of polysaccharide. These results were interpreted in terms of size exclusions of polymer sugars by the water domains of the liquid crystal phases as well as the different topologies of water channels. Molecular dynamics simulations of polysaccharides in the water environment were performed to support these findings. 相似文献
80.
Lubda D Lindner W Quaglia M du Fresne von Hohenesche C Unger KK 《Journal of chromatography. A》2005,1083(1-2):14-22
The porosity of monolithic silica columns is measured by using different analytical methods. Two sets of monoliths were prepared with a given mesopore diameter of 10 and 25 nm, respectively and with gradated macropore diameters between 1.8 and 7.5 microm. After preparing the two sets of monolithic silica columns with different macro- and mesopores the internal, external and total porosity of these columns are determined by inverse size-exclusion chromatography (ISEC) using polystyrene samples of narrow molecular size distribution and known average molecular weight. The ISEC data from the 4.6 mm analytical monolithic silica columns are used to determine the structural properties of monolithic silica capillaries (100 microm I.D.) prepared as a third set of samples. The ISEC results illustrate a multimodal mesopore structure (mesopores are pores with stagnant zones) of the monoliths. It is found by ISEC that the ratio of the different types of pores is dependent on the change in diameter of the macropores (serve as flow-through pores). The porosity data achieved from the mercury penetration measurement and nitrogen adsorption as well of scanning electron microscopy (SEM) and transmission electron microscopy (TEM) pictures are correlated with the results we calculated from the ISEC measurements. The ISEC results, namely the multimodal pore structure of the monoliths, reported in several publications, are not confirmed analyzing the pore structures of the different silica monoliths using all other analytical methods. 相似文献