超几何光场态与二能级原子相互作用中原子反转的演化及光场的反聚束效应

研究作为二项式态单参数推广的超几何态与二能级原子的强度耦合相互作用．讨论了原子反转的动力学演化以及光场的反聚束效应．     

Synthesis of Chiral Triarylmethanes Bearing All‐Carbon Quaternary Stereocenters: Catalytic Asymmetric Oxidative Cross‐Coupling of 2,2‐Diarylacetonitriles and (Hetero)arenes

A direct and enantioselective oxidative cross‐coupling of racemic 2,2‐diarylacetonitriles with electron‐rich (hetero)arenes has been described, which allows for efficient construction of triarylmethanes bearing all‐carbon quaternary stereocenters with excellent chemo‐ and enantioselectivity. The reaction has an excellent functional group tolerance, and exhibits a broad scope with respect to both 2,2‐diarylacetonitrile and (hetero)arene components. The rich chemistry of the cyano group allows for facile synthesis of other valuable chiral triarylmethanes bearing all‐carbon quaternary centers that are otherwise difficult to access.     

Biomimetic Synthesis of Rhytidenone A and Mode of Action of Cytotoxic Rhytidenone F

The rhytidenone family comprises spirobisnaphthalene natural products isolated from the mangrove endophytic fungus Rhytidhysteron rufulum AS21B. The biomimetic synthesis of rhytidenone A was achieved by a Michael reaction/aldol/lactonization cascade in a single step from the proposed biosynthetic precursor rhytidenone F. Moreover, the mode of action of the highly cytotoxic rhytidenone F was investigated. The pulldown assay coupled with mass spectrometry analysis revealed the target protein PA28γ is covalently attached to rhytidenone F at the Cys92 residue. The interactions of rhytidenone F with PA28γ lead to the accumulation of p53, which is an essential tumor suppressor in humans. Consequently, the Fas‐dependent signaling pathway is activated to initiate cellular apoptosis. These studies have identified the first small‐molecule inhibitor targeting PA28γ, suggesting rhytidenone F may serve as a promising natural product lead for future anticancer drug development.     

Biomimetic Synthesis of Rhytidenone A and Mode of Action of Cytotoxic Rhytidenone F

The rhytidenone family comprises spirobisnaphthalene natural products isolated from the mangrove endophytic fungus Rhytidhysteron rufulum AS21B. The biomimetic synthesis of rhytidenone A was achieved by a Michael reaction/aldol/lactonization cascade in a single step from the proposed biosynthetic precursor rhytidenone F. Moreover, the mode of action of the highly cytotoxic rhytidenone F was investigated. The pulldown assay coupled with mass spectrometry analysis revealed the target protein PA28γ is covalently attached to rhytidenone F at the Cys92 residue. The interactions of rhytidenone F with PA28γ lead to the accumulation of p53, which is an essential tumor suppressor in humans. Consequently, the Fas-dependent signaling pathway is activated to initiate cellular apoptosis. These studies have identified the first small-molecule inhibitor targeting PA28γ, suggesting rhytidenone F may serve as a promising natural product lead for future anticancer drug development.     

Preparative separation of vitexin and isovitexin from pigeonpea extracts with macroporous resins

Vitexin and isovitexin are a pair of isomeric compounds known as the major constituents in pigeonpea leaves and possess various pharmacological activities. In the present study, the preparative separation of vitexin and isovitexin with macroporous resins (Nankai Hecheng S & T, Tianjin, China) was studied. The performance and adsorption characteristics of eight macroporous resins including ADS-5, ADS-7, ADS-8, ADS-11, ADS-17, ADS-21, ADS-31 and ADS-F8 have been evaluated. The research results indicate that ADS-5 resin is most appropriate for the separation of vitexin and isovitexin. Langmuir and Freundlich isotherms were used to describe the interactions between solutes and resin at different temperatures, and the equilibrium experimental data were well fitted to the two isotherms. Column packed with ADS-5 resin was used to perform dynamic adsorption and desorption tests to optimize the separation process. The optimum parameters for adsorption were as follows: the concentration of vitexin and isovitexin in sample solution: 0.22 and 0.40mg/mL, respectively, processing volume: 3 BV, flow rate: 1mL/min, pH 4, temperature: 25 degrees C; for desorption: ethanol-water (40:60, v/v), 5 BV as an eluent, flow rate: 1mL/min. After one run treatment with ADS-5 resin, the contents of vitexin and isovitexin were increased 4.07-fold and 11.52-fold from 0.86%, 1.53% to 3.50% and 17.63%, the recovery yields were 65.03% and 73.99%, respectively. In conclusion, the preparative separation of vitexin and isovitexin can be easily and effectively achieved via adsorption and desorption on ADS-5 resin, and the method can be referenced for the separation of other flavone C-glucosides from herbal materials.     

Reactive sulfur species: hydrolysis of hypothiocyanite to give thiocarbamate-S-oxide

Hypothiocyanite (OSCN-) hydrolyzes under alkaline conditions to give thiocarbamate-S-oxide (H2NC(=O)SO-, the conjugate base of carbamothioperoxoic acid) via a mechanism that involves rate-limiting nucleophilic attack of OH- on OSCN-, followed by fast protonation (with no net consumption of H+/OH- at pH 11.7). Thiocarbamate-S-oxide has been characterized by 13C NMR, 15N NMR, UV spectroscopy, and ion chromatography. It has also been independently synthesized by the reaction of thiocarbamate (H2NC(=O)S-) and hypochlorite (OCl-). The properties of thiocarbamate-S-oxide that is produced by hydrolysis of OSCN- and by oxidation of H2NC(=O)S- are the same. The possible relevance of thiocarbamate-S-oxide in human peroxidase defense mechanisms remains to be explored.     

光数字相干接收机中色散补偿模块设计与优化

在高速光纤通信数字相干接收系统中,色散补偿模块的结构和性能将直接决定其是否具有实用价值.设计了比传统的有限脉冲响应(FIR)滤波器结构简单的偶对称型FIR滤波器,并通过数值仿真分析了FIR滤波器长度选取对补偿效果的影响.研究结果表明,在接收端光信噪比(OSNR)代价不高于1 dB的情况下,FIR滤波器长度折衷选取为最大...     

Demonstration of PMD compensation by using a DSP-Based OPMDC prototype in a 43-Gb/s RZ-DQPSK, 1200 km DWDM transmission

This paper reports the DSP-based prototype compensator we have made to compensate the polarization mode dispersion (PMD) in fibers. It was tested in one channel of a 40 × 43-Gb/s DWDM DQPSK system, which is the commercial product line, either in the back-to-back case by using a PMD emulator, or in a 1200-km transmission testbed. The prototype showed a good performance under the tests of fast SOP and PSP rotation, DGD jump variation, and moderate knock on the testbed in a period as long as 12 h.     

不同长细比圆钢管混凝土柱偏心试验研究

针对不同长细比圆钢管混凝土短柱试件进行了试验研究, 介绍了 试验参数、试验装置和方法, 得到载荷与应变、载荷与挠度的曲线, 分析了长细比 对该类构件力学性能的影响规律, 并应用相关规程进行了极限承载力的验算, 针对 该类构件在工程中的应用提出了合理的建议. 结果表明, 随着长细比的增大, 钢管 对核心混凝土的约束作用不断减弱, 极限承载力也明显下降, 而其横向变形能力逐 渐减弱, 在延性方面则影响不大. 试件达到极限承 载力时对应受压区的纵环向应变也比较大.     

Kinetics of the reversible reaction of CO2(aq) with ammonia in aqueous solution

The kinetics of the interactions of aqueous ammonia with aqueous carbon dioxide/carbonate species has been investigated using stopped-flow techniques by monitoring the pH changes via indicators. The reactions include the reversible formation of ammonium carbamate/carbamic acid. A complete reaction mechanism has been established, and the temperature dependence of all rate and equilibrium constants including the protonation constant of the amine between 15 and 45 °C are reported and analyzed in terms of Arrhenius, Eyring, and van't Hoff relationships.