Determination of Thyroxine with Capillary Electrophoretic Enzyme Immunoassay

Capillary electrophoretic immunoassay (CEIA) is a new analytical technique1,2. In CEIA, the detection methods were UV absorbance detection1 and laser induced fluorescence detection (LIF)2. However, The UV detection is lack of sensitivity. The LIF is difficult to use due to its high cost, and furthermore, most biological fluids are strongly luminescent when excited by the laser in the blue or green region of the spectrum. In our present work, a capillary electrophoretic enzyme immuno…     

关于集值目标映射的向量平衡问题的广义Tykhonov适定性

引入集值目标映射的向量平衡问题的两类广义Tykhonov适定性,利用非紧性Kuratowski测度给出它们的度量刻划和讨论这两类适定性的充分性条件.最后证明向量平衡问题的广义Tykhonov适定性与约束极小化问题的广义Tykhonov适定性之间的等价关系.     

取代基对1-甲基尿嘧啶与N-甲基乙酰胺氢键复合物中氢键强度的影响

使用密度泛函理论B3LYP方法和二阶微扰理论MP2方法对由1-甲基尿嘧啶与N-甲基乙酰胺所形成的氢键复合物中的氢键强度进行了理论研究, 探讨了不同取代基取代氢键受体分子1-甲基尿嘧啶中的氢原子对氢键强度的影响和氢键的协同性. 研究表明: 供电子取代基使N－H…O＝C氢键键长r(H…O)缩短, 氢键强度增强; 吸电子取代基使N－H…O＝C氢键键长r(H…O)伸长, 氢键强度减弱. 自然键轨道(NBO)分析表明: 供电子基团使参与形成氢键的氢原子的正电荷增加, 使氧原子的负电荷增加, 使质子供体和受体分子间的电荷转移量增多; 吸电子基团则相反. 供电子基团使N－H…O＝C氢键中氧原子的孤对电子轨道n(O)对N－H的反键轨道σ^*(N－H)的二阶相互作用稳定化能增强, 吸电子基团使这种二阶相互作用稳定化能减弱. 取代基对与其相近的N－H…O＝C氢键影响更大.     

四苯乙烯衍生物的合成、性能及其对铀酰离子的荧光识别

聚集诱导发光(AIE)效应在铀酰离子痕量检测方面具有广阔的应用前景。本文以四苯乙烯(TPE)为母体,设计合成了一种TPE席夫碱类化合物T2,并对其溶液态和聚集态的光学性质进行了表征。结果表明,T2具有AIE特性。并且,当向T2中加入铀酰离子后,体系荧光发射峰从540nm蓝移到500nm,肉眼可见由黄色到黄绿色的明显颜色变化,表明化合物T2可用于检测水体中的铀酰离子。     

Antioxidative Effect of Schiff Bases with o-Hydroxybenzylidene Groupon Free Radical Induced Hemolysis of Human Red Blood Cell

IntroductionThe recent development of free radical biologyand medicine has provided a great deal of clinicaland experimental evidence indicating that the freeradical induced peroxidation of membrane lipids isassociated with a variety of chronic healthproblems,such as cancer,atherosclerosis andageing[1,2 ] . Both natural and synthetic antioxidantshave been used to trap peroxyl radicals and/orinitiating radicals to protect the membrane lipidsagainst free radical chain reactions,and hence mayhave…     

Synthesis and Properties of An Aminated hypocrellin B

Photodynamic therapy (PDT), using red light and photosensitizers (Sens ), is a promising new treatment for tumor. The naturally occurred hypocrellins,including hypocrellin A (HA) and hypocrellin B (HB,1), have been proposed as the potential photosensitizers for PDT. It has been the subject of many investigations to improve the red absorption and water-solubility of natural hypocrellins by the structural modifications1~3. In this paper, a new derivative 2 was synthesized from 1 and charact…     

The Reaction of CH_3+NO in Gaseous Phase

NOx is a major pollutant product from combustion processes. In hydrocarbon combustion there are a number of radicals as CH2, C2H, CH3 and C2H3 can react with NO1-3. A large amount of CH3 exists in natural gas combustion flame. Therefore the reaction of CH3 with NO is very important. A rate constant (k =1.510-11exp(-60k/T) cm3molecule-1s-1) of the overall CH3+NO reaction was measured with laser flash photolysis/absorption spectroscopy over the temperature range 296-509 K and at pre…     

A Novel Hexanordammarane Glycoside from the Roots of Panax notoginseng

There are extensive chemical studies on the roots of Panax notoginseng (Burk.) F. H. Chen, a famous traditional Chinese medicine called San-Qi or Tian-Qi, thirty-three dammarane saponins were isolated and their structures were identified by our group and other scientists1-8. Further chemical investigation on this plant led to the isolation of a novel hexanordammarane glycoside, named notoginsenoside R10 (1).Notoginsenoside R10 (1), white powder, negative HRFAB-MS showed a quasimolecular…     

In Vitro Interaction of Nicotine and Hemoglobin under Liver Cell Metabolizing Condition

Nicotine, 3-(1-methyl-2-pyrrolidinyl)pyridine, the main alkaloid in tobacco products, has been well known for its addiction effect. Habitual smokers are usually maintaining nicotine concentration constant in their blood at about 10-15 ng/mL1. Therefore the interaction of nicotine and hemoglobin (Hb) is essential to be studied. Our recent study by accelerator mass spectrometry (AMS) has shown that nicotine could form adducts with Hb after in vivo administration, and there is a positive dose r…