N,N′-苄基-1,2二胺合铜的合成和晶体结构及与DNA的相互作用(英文)

A ligand,(N,N′-dibenzylethane-1,2-diamine)(L),and its complex with copper acetate was synthesized and characterized by some spectral analyses.The copper ! ion is six-coordinated and exhibites octahedral coordination geometry,the coordination atoms are four nitrogen atoms from two(L) ligands and two carboxyl oxygen atoms from two acetic acid groups,respectively.After studying the interaction of the complex with calf thymus DNA through UV and fluorescence spectra,we can find that there is a strong binding and a large affinity berween the complex and calf thymus DNA.CCDC: 649416.     

Stereoselective synthesis of (+)-SCH 351448: a unique ligand system for sodium, calcium, and other cations

(+)-SCH 351448 (Na+ salt A) was synthesized employing ring-closing olefin metathesis reaction of an open diene diester intermediate for construction of the 28-membered macrodiolide structure. The open diene diester was prepared from the monomeric hydroxy carboxylic acid and two different olefin fragments. The monomeric hydroxy acid was synthesized via Julia-Julia coupling reaction of intermediates derived from the same olefinic fragments. Oxane units in these fragments were prepared by radical cyclization reactions of beta-alkoxyacrylates. Analogous SCH 351448 salts incorporating other mono- and divalent cations may be prepared. Under acidic conditions, SCH 351448 (Na+ salt A) was the most stable complex, but SCH 351448 (Ca2+ salt) and (Na+ salt B) appear to be physiologically important species.     

可生物降解聚合物药物释放数学模拟研究进展

由于可降解的聚合物作为药物载体可以使得药物释放具有较高的靶向性、药物释放更加平缓 ,特别是可以使一些不稳定、半衰期短的药物在人体内达到可控制释放的效果 ,因此将可降解聚合物应用于药物释放体系中作为药物载体得到了较深入的研究。随着研究的深入 ,通过数学方法模拟或预测聚合物载体的降解过程以及聚合物降解过程中药物的释放行为是控释体系设计与应用的一个重要发展方向。由于影响因素较多 ,将所有因素逐一考虑将使得数学模型过于庞杂而失去实际意义 ,所以一个数学模型通常只考虑最主要几个的影响因素 ,并对药物释放系统进行相应的假设。目前文献中报道的降解 (溶蚀 )控制药物释放体系的数学模型大致可以分为两类 :假设药物释放按照零级过程 (zeroorderprocess)进行的经验模型和考虑影响药物释放的多种物理化学过程(如局部传质、化学反应 )的理论模型。本文综述了这些理论模型及其研究进展     

Study of Tea Digitized Chromatographic Fingerprint Spectra Using Micellar Electrokinetic Chromatography

IntroductionTeaisthemostwidelyconsumedbeverageinpeople’slife .Theheightenedpopularityofthisbeveragethroughouttheworldinrecentyearsmaybedueinparttotheevidenceofarelationshipbetweenteaconsumptionandpreventionofcertainformsofhumandisease .Themaincomponentsofteaarepolyphenoliccompounds ,commonlyknownascatechins ,whichrepresentagroupofcom poundsbelongingtotheflavonoidfamily .Thesecom poundsarewidelydistributedinthetealeavesandconsti tuteupto 30 %ofthedryleafweight.1Muchinteresthasbeenfocusedoncat…     

α-硝基环烷酮的制备及其合成应用

介绍了α-硝基环烷酮的制备方法, 以及它们的特殊反应性和合成应用, 参考文献40多篇.     

高配位双环氮氧杂有机锡化合物在二甲亚砜溶剂中的酸性解离常数

本文报道了在DMSO溶剂中利用Bordwell指示剂重迭法测定六种高配位双环氮氧杂有机锡化合物的α-CH的酸性离解常数(pKa)的方法, 并对配合物的结构与其α-CH酸性的关系进行了讨论。     

端视等离子体原子发射光谱仪的性能评价

端视等离子体原子发射光谱仪与侧视等离子体原子发射光谱仪相比在分析性能方面所表现出来的差异一直是光谱分析工作者所关注的一个重要方面。此文较系统的总结了近年来在此方面所做的研究工作，引用47篇文献。     

稀土铜硫化合物TbCuS2的合成和晶体结构

Terbium copper disulfide, TbCuS₂, has been synthesized in the reaction of the elements in a KI flux at 850 ℃. The compound crystallizes in space group P2₁/c of the monoclinic system with four formula units in a cell of dimensions of a= 0.639 3(1) nm, b=0.702 5(1) nm, c=0.670 8(1) nm, β=98.097(4)°, and V=0.298 3(1) nm³ at 153 K. The structure comprises two-dimensional ²_∞[CuS₂] layers along [100] separated by the Tb atoms. In the structure, each Tb and Cu atoms are coordinated to seven and four S atoms, respectively. CSD: 415490.     

Studies on the Phase Properties of Winsor Ⅰ-Ⅲ Type Microemulsions with Dielectric Relaxation Spectroscopy

The dielectric relaxation spectroscopy （DRS） of Winsor I -Ⅲ microemulsions for nonionic surfactant octyl polyglucoside CsG1.46/1-butanol/cyclohexanedwater system was studied. The experiment shows that the permittivity decreases with the increase in the frequency and clear dielectric relaxation phenomena were observed. Permittivity obviously decreases with the change of the microstructure of the microemulsion, W/O, B.C. and O/W can be distinguished by the permittivity.