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991.
Xiang Luo Qinghai Lian Wenwei Li Liqing Chen Renyu Zhang Deying Yang Lingqiang Gao Xiaoxiao Qi Zhongqiu Liu Guochao Liao 《Chemical science》2021,12(48):15998
A new strategy based on a macrophage-inducible C-type lectin (Mincle) agonist was established to construct synthetic cancer vaccines. Using sialyl-Tn (STn) as a model antigen, four conjugates with the Mincle agonist as a built-in adjuvant were designed and synthesized through a facile and efficient method. All conjugates could induce BMDMs to produce inflammatory cytokines in a Mincle-dependent manner and were found to elicit robust humoral and T cell-dependent immune responses alone in mice. The corresponding antibodies could recognize, bind and exhibit complement-dependent cytotoxicity to STn-positive cancer cells, leading to tumor cell lysis. Moreover, all conjugates could effectively inhibit tumor growth and prolong the mice survival time in vivo, with therapeutic effects better than STn-CRM197/Al. Notably, compared to conventional glycoprotein conjugate vaccines, these fully synthetic conjugate vaccines do not cause “epitope suppression.” Mincle ligands thus hold great potential as a platform for the development of new vaccine carriers with self-adjuvanting properties for cancer treatment. Preliminary structure–activity relationship analysis shows that a vaccine containing one STn antigen carried by vizantin exhibits the best efficacy, providing support for further optimization and additional investigation into Mincle agonists as the carrier of self-adjuvanting cancer vaccines.A new strategy based on a Macrophage-inducible C-type lectin (Mincle) agonist was established to construct synthetic cancer vaccines. 相似文献
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Dong-Yu Kim Taek-Seung Lee Sukant K. Tripathy Xin Li Jiang Lian Li Jayant Kumar 《Macromolecular Symposia》1997,116(1):127-134
Surface relief gratings were optically produced on a number of azobenzene-based polymer films. The surface grating formation was investigated by monitoring the diffraction efficiency and using atomic force microscopy. The effect of the structure of the chromophores on surface modulation was investigated. The surface deformation process depended on the polarization state of the writing beams. The localized variations of the light intensity and alteration of the resulting electric field polarization were essential writing conditions to the formation of the surface relief gratings. The surface pattern from straight edge diffraction established that the surface profile of the recorded gratings is proportional to negative gradient of the intensity pattern incident on the polymer film. 相似文献
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Flow-area (QA) method and ln(diameter)-velocity (ln(D)U) methods based on si-multaneous measurements of velocity (U) and arterial diameter (D) using ultrasound ... 相似文献
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Incompressible multiphase flow and encapsulation simulations using the moment‐of‐fluid method 下载免费PDF全文
Guibo Li Yongsheng Lian Yisen Guo Matthew Jemison Mark Sussman Trevor Helms Marco Arienti 《国际流体数值方法杂志》2015,79(9):456-490
A moment‐of‐fluid method is presented for computing solutions to incompressible multiphase flows in which the number of materials can be greater than two. In this work, the multimaterial moment‐of‐fluid interface representation technique is applied to simulating surface tension effects at points where three materials meet. The advection terms are solved using a directionally split cell integrated semi‐Lagrangian algorithm, and the projection method is used to evaluate the pressure gradient force term. The underlying computational grid is a dynamic block‐structured adaptive grid. The new method is applied to multiphase problems illustrating contact‐line dynamics, triple junctions, and encapsulation in order to demonstrate its capabilities. Examples are given in two‐dimensional, three‐dimensional axisymmetric (R–Z), and three‐dimensional (X–Y–Z) coordinate systems. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
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