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401.
402.
Umberto Marconi 《Rendiconti del Circolo Matematico di Palermo》2001,50(3):543-546
The purpose of this note is proving a result of Nogura and Shakhmatov [4, Theorem 4]. Furthermore, a characterization of connected
spaces with a selection is given.
Work supported by the research project “Metodi e problemi in Analisi Reale” of the Italian Ministero dell'Università e della
Ricerca Scientifica e Tecnologica. 相似文献
403.
Silvia Panzeri Daniela Arosio Silvia Gazzola Laura Belvisi Monica Civera Donatella Potenza Francesca Vasile Isabell Kemker Thomas Ertl Norbert Sewald Oliver Reiser Umberto Piarulli 《Molecules (Basel, Switzerland)》2020,25(24)
Integrin ligands containing the tripeptide sequences Arg-Gly-Asp (RGD) and iso-Asp-Gly- Arg (isoDGR) were actively investigated as inhibitors of tumor angiogenesis and directing unit in tumor-targeting drug conjugates. Reported herein is the synthesis, of two RGD and one isoDGR cyclic peptidomimetics containing (1S,2R) and (1R,2S) cis-2-amino-1-cyclopentanecarboxylic acid (cis-β-ACPC), using a mixed solid phase/solution phase synthetic protocol. The three ligands were examined in vitro in competitive binding assays to the purified αvβ3 and α5β1 receptors using biotinylated vitronectin (αvβ3) and fibronectin (α5β1) as natural displaced ligands. The IC50 values of the ligands ranged from nanomolar (the two RGD ligands) to micromolar (the isoDGR ligand) with a pronounced selectivity for αvβ3 over α5β1. In vitro cell adhesion assays were also performed using the human skin melanoma cell line WM115 (rich in integrin αvβ3). The two RGD ligands showed IC50 values in the same micromolar range as the reference compound (cyclo[RGDfV]), while for the isoDGR derivative an IC50 value could not be measured for the cell adhesion assay. A conformational analysis of the free RGD and isoDGR ligands by NMR (VT-NMR and NOESY experiments) and computational studies (MC/EM and MD), followed by docking simulations performed in the αVβ3 integrin active site, provided a rationale for the behavior of these ligands toward the receptor. 相似文献
404.
Umberto Raucci Maria Gabriella Chiariello Federico Coppola Fulvio Perrella Marika Savarese Ilaria Ciofini Nadia Rega 《Journal of computational chemistry》2020,41(20):1835-1841
Electrons and protons are the main actors in play in proton coupled electron transfer (PCET) reactions, which are fundamental in many biological (i.e., photosynthesis and enzymatic reactions) and electrochemical processes. The mechanism, energetics and kinetics of PCET reactions are strongly controlled by the coupling between the transferred electrons and protons. Concerted PCET reactions are classified according to the electronical adiabaticity degree of the process. To discriminate among different mechanisms, we propose a new analysis based on the use of electron density based indexes. We choose, as test case, the 3-Methylphenoxyl/phenol system in two different conformations to show how the proposed analysis is a suitable tool to discriminate between the different degree of adiabaticity of PCET processes. The very low computational cost of this procedure is extremely promising to analyze and provide evidences of PCET mechanisms ruling the reactivity of many biological and catalytic systems. 相似文献
405.
Mariangela Lopreiato Rossana Cocchiola Susanna Falcucci Martina Leopizzi Michele Cardone Valeria Di Maio Umberto Brocco Valerio D'Orazi Stefano Calvieri Roberto Scandurra Federico De Marco Anna Scotto d'Abusco 《Photochemistry and photobiology》2020,96(1):74-82
The ultraviolet (UV) component of solar radiation is the driving force of life on earth, but it can cause photoaging and skin cancer. In this study, we investigated the effects of the glucosamine-derivative 2-(N-Acetyl)-L-phenylalanylamido-2-deoxy-β-D-glucose (NAPA) on human primary fibroblasts (FBs) stimulated in vitro with environmental levels of UVB radiation. FBs were irradiated with 0.04 J cm−2 UVB dose, which resulted a mild dosage as shown by the cell viability and ROS production measurement. This environmental UVB dose induced activation of MAP kinase ERK 1/2, the stimulation of c-fos and at lower extent of c-jun, and in turn AP-1-dependent up-regulation of pro-inflammatory factors IL-6 and IL-8 and suppression of collagen type I expression. On the contrary, 0.04 J cm−2 UVB dose was not able to stimulate metalloprotease production. NAPA treatment was able to suppress the up-regulation of IL-6 and IL-8 via the inhibition of MAP kinase ERK phosphorylation and the following AP-1 activation, and was able to attenuate the collagen type I down-regulation induced by the UVBs. Taken together, our results show that NAPA, considering its dual action on suppression of inflammation and stimulation of collagen type I production, represents an interesting candidate as a new photoprotective and photorepairing agents. 相似文献
406.
The authors consider a system of interacting particles subjected to Langevin inertial dynamics and derive the governing time-dependent equation for the one-body density. They show that, after suitable truncations of the Bogoliubov-Born-Green-Kirkwood-Yvon hierarchy, and a multiple time scale analysis, they obtain a self-consistent equation involving only the one-body density. This study extends to arbitrary dimensions previous work on a one-dimensional fluid and highlights the subtleties of kinetic theory in the derivation of dynamical density functional theory. 相似文献
407.
The paper contains some algebraic results on several varieties of algebras having an (interlaced) bilattice reduct. Some of these algebras have already been studied in the literature (for instance bilattices with conflation, introduced by M. Fitting), while others arose from the algebraic study of O. Arieli and A. Avron??s bilattice logics developed in the third author??s PhD dissertation. We extend the representation theorem for bounded interlaced bilattices (proved, among others, by A. Avron) to unbounded bilattices and prove analogous representation theorems for the other classes of bilattices considered. We use these results to establish categorical equivalences between these structures and well-known varieties of lattices. 相似文献
408.
Enrico Millo Elena Zocchi Andrea Galatini Umberto Benatti Gianluca Damonte 《合成通讯》2013,43(19):3260-3269
Pyrophosphate-linked coenzymes play essential roles in several biochemical systems. Symmetrical diadenosine-5′-pyrophosphate (Ap2A) has been synthesized from adenosine-5′-phosphate in virtually quantitative yield. The simple procedure is carried out in anhydrous pyridine using adenosine phosphoromorpholidate and adenosine monophosphate bis-(tri-n-butylammonium salt) as coupling reagents. 相似文献
409.
Umberto Lucia 《Physica A》2008,387(14):3454-3460
The constructal theory is based on the thought that flow architecture is a consequence of a principle of maximization of flow access, in time, and in flow configuration that is free to be realised. The principle of maxima for the variation of the entropy due to irreversibility represents a general principle of investigation for the stability of open systems, by which it is possible to predict some macroscopic shapes, originated by the spatial organisation, in Nature, both in living and in non-living objects. Its statistical meaning has recently been introduced. Here a statistical and dynamical interpretation for the entropy due to irreversibility is proposed as a foundation of the constructal theory. 相似文献
410.