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131.
Karine Porte Brigitte Renoux Elodie Praudeau Jonathan Clarhaut Balkis Eddhif Pauline Poinot Edmond Gravel Eric Doris Anne Wijkhuisen Davide Audisio Sbastien Papot Frdric Taran 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(19):6432-6436
A bioorthogonal approach is explored to release the content of nanoparticles on demand. Exploiting our recently described click‐and‐release technology, we developed a new generation of cleavable micelles able to disassemble through a sequential enzymatic and bioorthogonal activation process. Proof‐of‐concept experiments showed that this new approach could be successfully used to deliver the substances encapsulated into micelles in living cells as well as in mice by two complementary targeted strategies. 相似文献
132.
New upper-rim polyphosphorylated calix[4]arenes were designed for decorporation of uranium in case of nuclear contamination. A ligand system containing four preorganized 1-hydroxymethylene-1,1-bisphosphonic acid moieties anchored onto a calix[4]arene platform has been developed. Three calix[4]arene-bisphosphonates were efficiently prepared in multi-step syntheses with a variable carbon chain length between the bisphosphonate and the calix[4]arene. Affinity constants towards uranyl ion were determined and compared with those of bis(HEDP) and tris(HEDP) phosphonates, known as efficient ligands for uranyl. 相似文献
133.
L. N. Vakhitova K. V. Matvienko N. A. Taran N. V. Lakhtarenko A. F. Popov 《Russian Journal of Organic Chemistry》2011,47(7):965-973
The kinetics of oxidation of methylsulfanylbenzene and nucleophilic decomposition of diethyl 4-nitrophenyl phosphate with
hydrogen peroxide in the presence of ammonium hydrogen carbonate or boric acid in aqueous, aqueous-alcoholic, micellar, and
microemulsion media were studied. Quantitative parameters of the examined processes were determined, and the possibility of
using hydrogen peroxide for the design of oxidative nucleophilic decontaminating systems was demonstrated. 相似文献
134.
E. V. Lazareva A. V. Bryanskaya O. P. Taran Yu. P. Kolmogorov T. K. Malup S. E. Peltek S. M. Zhmodik 《Journal of Surface Investigation: X-ray, Synchrotron and Neutron Techniques》2012,6(6):1009-1018
Numerous bitter lakes, largely closed and shallow, are concentrated in a small area of the South of Western Siberia (Kulunda and Barabinsk steppes). Most lakes are marked by the development of thick black or grayish blue silt organogenic sediments formed due to the dying-off of local halophilic organisms. Salt lakes are of great interest for scientists. The investigation was conducted in the context of complex biological and biochemical studies aimed at identifying regularities in the redistribution of elements between components of a salt-lake system by SR-XRF (Synchrotron Radiation X-ray Fluorescence). 相似文献
135.
S. V. Stovbun A. A. Skoblin A. M. Zanin V. A. Tverdislov O. P. Taran V. N. Parmon 《Doklady Physical Chemistry》2018,479(1-2):57-60
It has been found that the UV-initiated formose reaction in an extremely concentrated aqueous solution of formaldehyde gives sugars and other biologically significant chiral compounds with sp3-hybridized carbon atom. The reaction leads to an optically active condensed phase, which is a result of the spontaneous spatial separation of enantiomers in the racemate into the antipodes, similarly to the separation of enantiomers of different chirality sign in the famous Pasteur experiments. In our opinion, such a scenario is as close as possible to the actually realized de novo scenario of synthesis of chiral prebiotic molecules and matrices. 相似文献
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137.
A. S. Morkovnik A. A. Spasov T. A. Kuz’menko A. F. Kucheryavenko L. N. Divaeva Yu. V. Koshchienko V. A. Anisimova L. G. Kuzmina N. V. Rogova V. A. Kuznetsova N. I. Chepljaeva O. A. Solovyova A. S. Taran E. S. Vorobiev D. A. Aleshin V. S. Sirotenko K. A. Gajdukova M. V. Bogoslavtseva 《Russian Chemical Bulletin》2015,64(11):2622-2631
Based on the X-ray crystallography and 1H NMR spectroscopy data and quantum chemical studies, it was found that 1(11)H-2, 3, 4, 5-tetrahydro[1, 3]diazepino[1, 2-a]benzimidazole (1) exists almost exclusively in the 1H-prototropic form. To prepare the fixed 11H-diazepinobenzimidazole forms of 1, 1-R-2-(4-chlorobutylamino)benzimidazoles (R = Me, N=CHAr) were synthesized, which underwent thermal cyclization with the formation of a mixture of 11-Rsubstituted diazepine 1 and 1-R-2-(pyrrolidin-1-yl)benzimidazole. Alkylation of diazepine 1 in a neutral medium regioselectively gave 11-R-diazepinobenzimidazoles in high yield. Their 1-substituted isomers were obtained by carrying out this reaction in the system NaH—THF. The N(11)-derivatives of diazepinobenzimidazole 1 were found to inhibit dipeptidyl peptidase 4 (DPP-4), but less actively than a comparator drug sitagliptin. The compounds under study did not exhibit antiglycation action in vitro and virtually did not affect activity of α-glucosidase and glycogen phosphorylase. However, they are characterized by a strong antiaggregant effect, making these derivatives promising for further studies. 相似文献
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