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11.
This research is made to visualize the boundary layer flow by a curved stretching sheet embedded in porous medium. The geometry is bended(curved), therefore the curvilinear coordinates are used to model the present problem.Fluid is electrically conducting with the presence of uniform magnetic field. The governing non-linear partial differential equation reduces to non-linear ordinary differential equations by using the dimensionless suitable transformations. The numerical solutions are obtained by using the method bvp4c from MATLAB. The effects of curvature parameter, nondimensional magnetic parameter, and porosity parameter on the velocity field and skin friction coefficient are examined.The skin friction profile enhances with enhancing the values of porosity and magnetic parameter. Comparison of the present results with the existing results in the literature for the flat surface is also given. 相似文献
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Farhat Jubeen Sania Zafar Iqbal Nusrat Shafiq Maryam Khan Shagufta Parveen Munawar Iqbal 《合成通讯》2018,48(6):601-625
Among all heterocyclic compounds, pyrimidine is of prime interest, exhibit broad spectrum of biological activities, because of its occurrence in deoxyribonucleic acid bases. The bioactive moiety pyrimidine has a voluminous therapeutic profile as it is a vital component of a series of natural composites and chemotherapeutic drugs. Since from last 50–60 years, this motif has been used commendably against bacterial, tuberculosis viral, malarial, fungal, and cancerous contagions. Recently, numerous pyrimidine derivatives were synthesized and discussed here, fused with other heterocyclic moieties, pyrazole, coumarine, triazole, alkenyloxindole, hydrazine and others, were also investigated for their bioactivities. Amid all recently reported compounds, several exhibit potentials against breast cancer cell lines. Intensive research has been performed and is going ahead with distinctive emphasis on antineoplastic potential of pyrimidine. These widespread medicinal attributes impulse scientists to synthesize more and more biologically active pyrimidine composites by following simple and eco-friendly routes. 相似文献
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Lixiang Zhang Zhengchao Yuan Muhammad Shafiq Youjun Cai Zewen Wang Piming Nie Xiumei Mo Yuan Xu 《Macromolecular bioscience》2023,23(4):2200500
Growth factors are essential for wound healing owing to their multiple reparative effects. Concentrated growth factor (CGF) is a third-generation platelet extract containing various endogenous growth factors. Herein, a CGF extract solution is combined with gelatin methacrylate (GM) by physical blending to produce GM@CGF hydrogels for wound repair. The GM@CGF hydrogels show no immune rejection during autologous transplantation. Compared to CGF, GM@CGF hydrogels not only exhibit excellent plasticity and adhesivity but also prevent rapid release and degradation of growth factors. The GM@CGF hydrogels display good injectability, self-healing, swelling, and degradability along with outstanding cytocompatibility, angiogenic functions, chemotactic functions, and cell migration-promoting capabilities in vitro. The GM@CGF hydrogel can release various effective molecules to rapidly initiate wound repair, stimulate the expressions of type I collagen, transform growth factor β1, epidermal growth factor, and vascular endothelial growth factor, promote the production of granulation tissues, vascular regeneration and reconstruction, collagen deposition, and epidermal cell migration, as well as prevent excessive scar formation. In conclusion, the injectable GM@CGF hydrogel can release various growth factors and provide a 3D spatial structure to accelerate wound repair, thereby providing a foundation for the clinical application and translation of CGF. 相似文献
14.
Muhammad Imran Abdul Qudair Baig Haidar Ali Shafiq Ur Rehman 《Periodica Mathematica Hungarica》2016,73(1):100-119
Topological indices are numerical parameters of a graph which characterize its topology and are usually graph invariant. In QSAR/QSPR study, physico-chemical properties and topological indices such as the Randi?, the atom-bond connectivity (ABC) and the geometric-arithmetic (GA) indices are used to predict the bioactivity of chemical compounds. Graph theory has found a considerable use in this area of research. In this paper, we study poly honeycomb networks which are generated by a honeycomb network of dimension n and derive analytical closed results for the general Randi? index \(R_\alpha (G)\) for different values of \(\alpha \), for a David derived network \((\textit{DD}(n))\) of dimension n, a dominating David derived network \((\textit{DDD}(n))\) of dimension n as well as a regular triangulene silicate network of dimension n. We also compute the general first Zagreb, ABC, GA, \(\textit{ABC}_4\) and \(\textit{GA}_5\) indices for these poly honeycomb networks for the first time and give closed formulas of these degree based indices in case of poly honeycomb networks. 相似文献
15.
Antioxidant and Anti-Inflammatory Effects of Peganum harmala Extracts: An In Vitro and In Vivo Study
Malik Waseem Abbas Mazhar Hussain Muhammad Qamar Sajed Ali Zahid Shafiq Polrat Wilairatana Mohammad S. Mubarak 《Molecules (Basel, Switzerland)》2021,26(19)
Peganum harmala (P. harmala) belongs to the family Zygophyllaceae, and is utilized in the traditional medicinal systems of Pakistan, China, Morocco, Algeria, and Spain to treat several chronic health disorders. The aim of the present study was to identify the chemical constituents and to evaluate the antioxidant, anti-inflammatory, and toxicity effects of P. harmala extracts both in vitro and in vivo. Sequential crude extracts including 100% dichloromethane, 100% methanol, and 70% aqueous methanol were obtained and their antioxidant and anti-inflammatory effects evaluated both in vitro and in vivo. The anti-inflammatory effect of the extract was investigated using the carrageenan-induced paw edema method in mice, whereas the toxicity of the most active extract was evaluated using an acute and subacute toxicity rat model. In addition, we have used the bioassay-guided approach to obtain potent fractions, using solvent–solvent partitioning and reversed phase high performance liquid chromatography from active crude extracts; identification and quantification of compounds from the active fractions was achieved using electrospray ionization mass spectrometry and high performance liquid chromatography techniques. Results revealed that the 100% methanol extract of P. harmala exhibits significant in vitro antioxidant activity in DPPH assay with an IC50 of 49 µg/mL as compared to the standard quercetin with an IC50 of 25.4 µg/mL. The same extract exhibited 63.0% inhibition against serum albumin denaturation as compared to 97% inhibition by the standard diclofenac sodium in an in vitro anti-inflammatory assay, and in vivo anti-inflammatory against carrageenan-induced paw edema (75.14% inhibition) as compared to 86.1% inhibition caused by the standard indomethacin. Furthermore, this extract was not toxic during a 14 day trial of acute toxicity when given at a dose of 3 g/kg, indicating that the lethal dose (LD50) of P. harmala methanol extract was greater than 3 g/kg. P. harmala methanolic fraction 2 obtained using bioassay-guided fractionation showed the presence of quinic acid, peganine, harmol, harmaline, and harmine, confirmed by electrospray ionization mass spectrometry and quantified using external standards on high performance liquid chromatography. Taken all together, the current investigation further confirms the antioxidant, anti-inflammatory, and safety aspects of P. harmala, which justifies its use in folk medicine. 相似文献
16.
Nitriding molybdenum: Effects of duration and fill gas pressure when using lO0-Hz pulse DC discharge technique 下载免费PDF全文
U. Ikhlaq ;R. Ahmad ;M. Shafiq ;S. Saleem ;M. S. Shah ;T. Hussain ;I. A. Khan ;K. Abbas ;M.S. Abbas 《中国物理 B》2014,(10):349-356
Molybdenum is nitrided by a 100-Hz pulsed DC glow discharge technique for various time durations and fill gas pressures to study the effects on the surface properties of molybdenum. X-ray diffractometry (XRD), scanning electron microscopy (SEM), and atomic force microscopy (AFM) are used for the structural and morphological analysis of the nitrided layers. Vickers' microhardness tester is utilized to investigate surface microhardness. Phase analysis shows the formation of more molybdenum nitride molecules for longer nitriding durations at fill gas pressures of 2 mbar and 3 mbar (1 bar = 105 Pa). A considerable increase in surface microhardness (approximately by a factor of 2) is observed for longer duration (10 h) and 2-mbar pressure. Longer duration (10 h) and 2-mbar fill gas pressure favors the formation of homogeneous, smooth, hard layers by the incorporation of more nitrogen. 相似文献
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18.
Ahmad Shafiq Nadeem Sohail Muhammad Noor Khan Muhammad Naveed 《Journal of Thermal Analysis and Calorimetry》2021,143(2):1187-1199
Journal of Thermal Analysis and Calorimetry - Cattaneo–Christov with variable thermal relaxation time and entropy generation is the main concern of this study. The micropolar fluid with... 相似文献
19.
A mild and efficient allylation/propargylation of indoles has been developed with high regioselectivity and excellent yields. In the presence of catalytic molecular iodine, various indoles could react with allylic/propargylic acetates smoothly at room temperature to exclusively provide C-3 alkylated products. 相似文献
20.
Muhammad Rafiq Muhammad Khalid Muhammad Nawaz Tahir Muhammad Umair Ahmad Muhammad Usman Khan Muhammad Moazzam Naseer Ataualpa Albert Carmo Braga Shabbir Muhammad Zahid Shafiq 《应用有机金属化学》2019,33(11)
Present study advocates the joint experimental and computational studies of two potent benzoimidazole‐based hydrazones with chemical formula C23H18F2N4O ( 5a ) and C25H22FN5O3 ( 5b ). Both 5a and 5b were synthesized and resolved into their crystal structures using SC‐XRD for the assessment of bond lengths, bond angles, unit cells and space groups. The structures of 5a and 5b were chemically characterized using infrared (FT‐IR), UV–Visible, nuclear magnetic resonance (1H‐NMR and 13C‐NMR), EIMS and elemental analysis. DFT at M06‐2X/6‐31G(d,p) level of theory was performed to get optimized structures and countercheck the experimental findings. Overall, DFT findings show excellent concurrence with the experimental data which confirms the purity of both compounds. FMO, NBO analysis, MEP surfaces and nonlinear optical (NLO) properties were explored at same level of theory. UV–Vis analysis at TDDFT/M06‐2X/6‐31G(d,p) level of theory showed that 5b is red shifted with λmax 331.69 nm as compared to 5a with λmax 240.25 nm. Global reactivity parameters were estimated using energy of FMOs indicated the greater harness value than the softness values of 5a and 5b . NBO analysis confirmed that the presence of non‐covalent interactions, hydrogen bonding and hyper conjugative interactions are pivotal cause for the existence of 5a and 5b in the solid‐state. NLO results of 5a and 5b were observed better than standard molecule recommended the NLO activity of said molecules for optoelectronic applications. 相似文献