Antiviral drug Triazavirin,selectively labeled with 2H, 13C,and 15N stable isotopes. Synthesis and properties

Chemistry of Heterocyclic Compounds - Isotope-labeled antiviral drug Triazavirin containing 2H, 13C, and 15N atoms in its structure has been synthesized. 13C2H3I and KS13CN served as donors of 13C...     

Redox conversions of new antiviral drug Triazavirin®: electrochemical study and ESR spectroscopy

Russian Chemical Bulletin - The results of studying electrochemical conversions of 7-R-3-X-1,2,4-triazolo[5,1-c][1,2,4]-triazin-4-ones (Triazavirin® and its derivatives) using cyclic...     

3-Cyanoazolo[5,1-c][1,2,4]triazines: synthesis and antiviral activity

Chemistry of Heterocyclic Compounds - A series of azolo[5,1-c][1,2,4]triazines containing a cyano group were prepared as analogs of the drug Triazavirin (riamilovir). Sodium...     

Nucleophilic substitution of halogen in 4-halo derivatives of glutamic acid

Reactions of diastereomeric dialkyl N-phthaloyl-4-haloglutamates withpara-anisidine were studied at high pressure, and an additional confirmation of the exactS _N2 mechanism of the reactions was obtained. Quantitative parameters of the relative reactivity of the diastereomers were found in various solvents, which made it possible to perform the desired synthesis of products of diastereomeric substitution. kg]Key words kw]glutamic acid kw]diastereoselectivity kw]nucleophilic substitution kw]reaction rate constant kw]high pressure.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 583–585, March, 1996.     

Isotopic hydrogen exchange in 1- and 2-aryl-5-methyltetrazoles

The rate constants for basic deuterium exchange of the methyl group (k_D) in 2-phenyl-5-methyl-tetrazole (I) and 1-aryl-5-methyltetrazole (II) and its derivatives with a polar substituent (R) in the phenyl ring were measured. The increased CH acidity of II as compared with I [k_D(II)/k_D(I)20] is in agreement with the calculated and experimental values regarding the character of the electron-density distribution in the molecules. The effect of R on the rate of deuterium exchange of the methyl group correlates with the ° constants (=3.0, r = 0.997). The results of measurement of the kinetic isotope effect during deuterium (tritium) exchange in II (k_D/k_T1.8) are discussed in connection with the peculiarities of the stepwise reaction mechanism.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No.1, pp. 127–130, January, 1978.