Ibuprofen induced drug loaded polymeric micelles

Three model drugs with different function groups were chosen to dialyze with dextran-graft-poly(N-isopropylacrylamide).Only ibuprofen could induce the formation of drug loaded micelles,which was confirmed with dynamic light scattering and transmission electron microscope.Hydrogen-bonding between the amide groups of poly(N-isopropylacrylamide) and the carboxyl groups of ibuprofen was driving force for the drug-loaded micelle.It was also found that the diameter of the ibuprofen-loaded micelles changed reversibly against temperature.     

Preparation and characterization of gradient distribution of silicon in emulsion blend films

In this work, a functional gradient polymeric material derived from silicon-containing acrylate blend emulsion film is prepared in two steps. Firstly, 3-[tris(trimethylsilyloxy)silyl] propyl methacrylate (TRIS)-modified acrylate latex is prepared using multiple emulsifiers by the two-stage semicontinuous emulsion copolymerization method. Next, blend latexes composed of TRIS-containing and TRIS-free acrylate latexes are obtained. Detailed studies on the effects of the film-formation temperature and the glass transition temperature (T _g) differences on the compositional gradient film are conducted. Surface energy analysis shows that silicon elements enriched at the film-air (F-A) interface and T _g differences facilitate the fabrication of silicon gradient in emulsion blend films. Scanning electron microscopy-energy dispersive X-ray further reveals that the concentration of silicon components varies in a gradient-like manner along the overall transaction of the film when the film-formation temperature is 55 °C. However, excessive temperature creates the formation of a segmental gradient distribution of silicon in the emulsion blend films.     

PdNi/Ni Nanotubes Assembled by Mesoporous Nanoparticles for Efficient Alkaline Ethanol Oxidation Reaction

The optimization of structure and composition is essential to improve the performance of catalysts. Herein, mesoporous nanoparticles assembled PdNi/Ni nanotubes (mPdNi/Ni NTs) are successfully fabricated using nickel nanowires as sacrificial template. The combination of nanotubular structure with mesoporous nanoparticle morphology can provide facilitated transfer channels and sufficient active sites, allowing the full contact and reaction between catalysts and reactants. Therefore, the synthesized mPdNi/Ni NTs exhibite superior ethanol oxidation performance to mesoporous Pd nanotubes and commercial Pd black. This study proposes a rational strategy for the development of nanoparticle assembled nanotubes with surface mesoporous morphology, which can greatly improve catalytic performance in various electrocatalytic fields.     

Solubility Calculations of Methane and Ethane in Aqueous Electrolyte Solutions

Journal of Solution Chemistry - Accurate calculation of light hydrocarbon solubilities in aqueous electrolyte solutions is critical for petroleum and geochemical applications. However, very few...     

An Efficient Method for The Synthesis of 4‐Arylfuro[2,3‐a][4,7]phenanthroline Derivatives Catalyzed by Iodine

A mild and an efficient method for the synthesis of 4‐arylfuro[2,3‐a][4,7]phenanthroline derivatives via three‐component reaction of aromatic aldehyde, quinolin‐6‐amine and 2,3‐dihydrofuran is described using iodine as catalyst. The features of this procedure are mild reaction conditions, good yields and operational simplicity.     

Discovery of new mutually orthogonal bioorthogonal cycloaddition pairs through computational screening

Density functional theory (DFT) calculations and experiments in tandem led to discoveries of new reactivities and selectivities involving bioorthogonal sydnone cycloadditions. Dibenzocyclooctyne derivatives (DIBAC and BARAC) were identified to be especially reactive dipolarophiles, which undergo the (3 + 2) cycloadditions with N-phenyl sydnone with the rate constant of up to 1.46 M^–1 s^–1. Most significantly, the sydnone-dibenzocyclooctyne and norbornene-tetrazine cycloadditions were predicted to be mutually orthogonal. This was validated experimentally and used for highly selective fluorescence labeling of two proteins simultaneously.     

Dipole bands in nucleus ~(139)Pm

High-spin states in nucleus 139Pm have been studied using the reaction 116Cd(27Al,4n)139Pm.Two dipole cascades have been found.Spin and parity assignments were based on the Directional Correlation of Oriented Nuclei(DCO) ratios and systematic behavior in neighboring odd-proton nuclei.The level structures of 139Pm are compared with those of the N =78 isotone 141Eu in which two dipole bands have been confirmed as magnetic rotational bands.The close similarity between them suggests that the dipole bands in 139...