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991.
992.
Y Fukuyama M Kodama I Miura Z Kinzyo H Mori Y Nakayama M Takahashi 《Chemical & pharmaceutical bulletin》1989,37(9):2438-2440
6,6'-Bieckol (1), 2-O-(2,4,6-trihydroxyphenyl)-6,6'-bieckol (4), and 8,8'-bieckol (2), bispolyphenols with a dibenzo-1,4-dioxin skeleton, have been isolated as potent anti-plasmin inhibitors from the brown alga Ecklonia kurome OKAMURA. Their structures have been determined to be dimers of eckol linked at the C-6 or C-8 positions, through an aryl-aryl bond on the basis of spectral data. Their inhibitory actions on anti-plasmins (alpha 2-macroglobulin and alpha 2-plasmin inhibitor) and some proteases have been examined. 相似文献
993.
Takushi Kurihara Yasuhiko Sakamoto Toshio Kobayashi Masanobu Mori 《Journal of heterocyclic chemistry》1978,15(5):737-743
Extensive studies of the Knoevenagel condensation of aromatic aldehydes and active methyl-lene compounds have been reported (2). In 1894, Knoevenagel reported (3) the reaction of benz-aldehyde with ethyl benzoylpyruvate in the presence of piperidine to give ehtyl benzyl-(bis-benzoyl)pyruvate, m.p. 162°, but no yield of the product was reported. This paper deals with the interesting results of the reactions of ethyl acetylpyruvate ( 2 ) ( 4 ) and ethyl benzoylpyruvate ( 3 ) (5) with some aromatic aldehydes ( 1a-f ). 相似文献
994.
Matsumi N Mori A Sakamoto K Ohno H 《Chemical communications (Cambridge, England)》2005,(36):4557-4559
Physical properties of liquid imidazole-borane complex were investigated to demonstrate their utility as aprotic polar solvents or liquid electrolytes appropriate for selective ion transport. 相似文献
995.
The direct oxygenation of s-trans dienes, silyl dienol ethers (SDEs) 2, by triphenyl phosphite ozonide (TPPO) has been examined in detail. The regioselective oxygenation was found to give hydroperoxide 3, alcohol 4, ketone 5, dimer 6, and peroxy phosphate 7 with concomitant formation of triphenyl phosphate 8 and diphenyl trimethylsilyl phosphate 10. The formation of peroxy phosphate 7 was found for the first time in TPPO oxygenation reactions. The low temperature (31)P and (1)H NMR spectroscopic analyses proved the direct reaction of SDEs with TPPO without generation of singlet oxygen. The formation of the oxygenated products 3-7 is reasonably explained by the intervention of the zwitterion ZI, which can be formed by the nucleophilic attack of SDE to the central oxygen of the ozonide. The regioselective attack of SDE to the central oxygen of the ozonide was supported by the quantum chemical calculation (B3LYP/6-31G). 相似文献
996.
Kunio Mori Akira Watanabe Aikou Muroi Yoshiro Nakamura 《Journal of polymer science. Part A, Polymer chemistry》1987,25(10):2893-2907
The three kinds of monomer films on metal surfaces were deposited by adsorption from a solution of 6-polymerizable substituents-1,3,5-triazine-2,4-dithiol monosodium salts (RTDN); the polymerizable substituents such as cis-9-octadecenylamino, di(cis-9-octadecenyl)amino, and p-vinylbenzyl(cis-9-octadecenyl)amino groups were selected in view of the polymerization activity of unsaturated groups in the substituents and the packing degree of monomer molecules. The monomer films were estimated to consist of mainly 6-substituents-1,3,5,-triazine-2,4-dithione (3H, 5H) and to be multimolecular layers that are considerably cross-packed and ordered. The monomer films on metal surfaces were polymerizable under a UV light irradiation in air atmosphere to give polymer films. In the photopolymerization, azobis(isobutyronitrile) (AIBN) was very effective for increasing the monomer conversion and the polymerization rate. The optimum concentration of AIBN in monomer films was very small, about 0.025 mol %. The monomer conversion was influenced by the kind of monomers, namely, the polymerization activity and the packing degree. The effect of the packing degree was especially remarkable. The monomer conversion decreased with an increase in the thickness of monomer films. This is because the polymerization was initiated by oxygen and AIBN, which were diffused into the inner of monomer films. The possibility of polymerization of the unsaturated groups and the thione groups in monomer molecules under UV light irradiation is discussed. 相似文献
997.
Kobayashi S Mori K Wakabayashi T Yasuda S Hanada K 《The Journal of organic chemistry》2001,66(16):5580-5584
A convergent total synthesis of khafrefungin, a novel inhibitor of fungal sphingolipid syntheses isolated from the fermentation culture MF6020, has been developed. Alkenylboronic acid 5 and alkenyliodide 6, key fragments for the total synthesis, were prepared from the corresponding achiral aldehydes using tin(II)-catalyzed and Zr(IV)-catalyzed asymmetric aldol reactions, respectively. The Suzuki coupling reaction of these two fragments was successfully performed to give 17 in good yield. Through the total synthesis, epimerization of the C4 position having a rather highly acidic proton did not occur, indicating that khafrefungin was under strict conformational constraints to prevent the epimerization process. This characteristic stability of khafrefungin has also been discussed using semiempirical calculation and synthesis. Finally, khafrefungin derivatives have also been synthesized, and their antifungal activities have been measured to obtain information on the structure--activity relationships. 相似文献
998.
Yoshida M Mori K Watanabe T Hasegawa T Sugibayash K 《Chemical & pharmaceutical bulletin》2000,48(11):1807-1809
The enhancing effect of electroporation on the in vitro skin permeation of benzoate was evaluated. Needle and ring electrodes made of Ag/AgCl were connected to an electrical power source, which produced exponentially decaying pulses. The needle electrode was kept in contact with the skin surface, and the ring electrode was positioned either on or under the skin. The electrical pulse was applied to abdominal hairless rat skin at 150-600 V every minute from 4 to 6 h during the 10-h permeation experiment. Skin permeation of benzoate was promoted by electroporation and the effect was increased by application of a higher voltage. No immediate recovery to the control flux, however, was observed for high voltage groups after turning off the voltage application. When the cathode and anode were separated by the skin membrane by setting in the epidermal and dermal sides, respectively, an iontophoretic effect may also play a role in benzoate flux. These results indicated that the drug permeation by electroporation is the result of passive diffusion and an iontophoretic effect as well as the electroporation effect. 相似文献
999.
Yoshiro Nakamura Kunio Mori 《Journal of polymer science. Part A, Polymer chemistry》1968,6(12):3269-3281
To obtain poly(vinyl chloride) (PVC) of excellent toughness, a new method of crosslinking PVC is proposed in which PVC is crosslinked with the soft segment in an elastomer such as liquid Thiokol. The reaction can be accomplished by immersing PVC–Thiokol blends in liquid ammonia at 20–30°C. A similar reaction occurs in aqueous ammonia when hexamethylphosphoramide is used as an activator. Characteristics of the crosslinked PVC thus obtained and of the controls of a similar uncrosslinked composition (PVC–Thiokol LP-8, 100:5 by weight) were as follows: tensile strength, 7.3 and 4.8 kg/mm2; elongation at break, 30 and 2.5%; Young's modulus, 3.5 × 104 and 2.9 × 104 kg/cm2; tensile impact, 88 and 15 kg-cm/cm3, respectively. The crosslinked PVC as plasticized with dioctyl phthalate (DOP) and the control blend (PVC–Thiokol LP-8–DOP, 100:10:10 by weight), respectively, showed tensile strengths of 5.9 and 4.8 kg/mm2, elongations at break of 44 and 24%, Young's moduli of 2.5 × 104 and 1.6 × 104 kg/cm2, and tensile impact strengths of 62 and 120 kg-cm/cm3. As the crosslinkage through the soft segments increases up to about 5%, the elongation at break, Young's modulus, and tensile impact, in addition to the tensile strength, are improved. This is different from the results so far observed with the crosslinked amorphous polymers and is characteristic of the products of crosslinking through the soft segment. The experimental results are discussed in this paper. 相似文献
1000.
Kenji Mori 《Tetrahedron letters》1981,22(35):3431-3432
The absolute configuration at C-3 of A-factor, 2-(6-methylheptanoyl)-3-hydroxymethyl-4-butanolide , was determined to be by synthesizing(3)-(+)-A-factor. 相似文献