An Improved Method for the Mono-Hydroxymethylation of Pyridines. A Modification of the Minisci Procedure

The reaction of N-methoxy-derivatives of pyridines in methanol with ammonium persulphate gives improved yields of mono-hydroxymethylated products. In contrast to the original Minisci procedure the reaction requires only catalytic amounts of ammonium persulphate. Evidence is presented which establishes that the reaction does not proceed via an intramolecular pathway.     

Synthesis and evaluation of some quinoline Schiff bases as a corrosion inhibitor for mild steel in 1 N HCl

N-((2-chloroquinolin-3-yl)methylene)aniline (CQM) and N-((2-chloroquinolin-3-yl)methylene)-5-methylthiazol-2-amine (CQMA) were synthesized. The effect of CQM and CQMA have been investigated against mild steel (MS) in 1 N HCl solutions using conventional weight loss, potentiodynamic polarization, linear polarization, electrochemical impedance spectroscopy, UV–Vis spectroscopy and scanning electron microscopic studies. The losses in the weights of MS samples have proved that both CQM and CQMA are efficient inhibitors. The mixed mode of inhibition was confirmed by electrochemical polarizations. The adsorptions of these inhibitors are found to follow the Langmuir adsorption isotherm. CQM and CQMA adsorbs on the MS sample by chemisorptions.     

Improved measurement of Vub with inclusive semileptonic B decays

We report a new measurement of the Cabibbo-Kobayashi-Maskawa parameter Vub made with a sample of 9.7 x 10(6) BB- events collected with the CLEO II detector. Using heavy quark theory, we combine the observed yield of leptons from semileptonic B decay in the end-point momentum interval 2.2-2.6 GeV/c with recent CLEO II data on B-->X(s)gamma to find Vub = (4.08+/-0.34+/-0.44+/-0.16+/-0.24)x10(-3), where the first two uncertainties are experimental and the last two are from theory.     

A mixing length model for turbulent flow in constant cross section ducts

In this paper, a study is made of the damping influence of the wall on turbulent fluid flow. By considering the oscillation of the whole of the boundary, van Driest's original hypothesis has been extended to obtain the wall damping factor in flow in a duct of constant cross section. The damping factor is used in conjunction with mixing length expressions to obtain the velocity field. Particular examples considered are plane parallel flow and axisymmetric flow in a pipe and in an annulus.

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Ein Modell für die Mischungslänge von turbulenten Strömungen in Rohren mit konstantem Querschnitt

Zusammenfassung In dieser Arbeit wurde der dämpfende Wandeinfluß in turbulenten Strömungen untersucht. Unter Berücksichtigung der Schwingungen in der gesamten Grenzschicht wurde die ursprüngliche Theorie von van Driest erweitert und ein Dämpfungsfaktor an der Wand in Rohrströmungen mit konstantem Querschnitt ermittelt. Dieser Dämpfungsfaktor diente in Verbindung mit Ausdrücken für die Mischungslänge zur Bestimmung des Geschwindigkeitsfeldes. Ausgewählte Beispiele waren die ebene Parallelströmung sowie die Zylinderströmung in einem Rohr und einem Ringspalt.

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Nomenclature A, A^*(=Au/v) Parameter defined in text - b, b^*(=bu/v) semi-width of parallel plate channel - c(= 1/A) parameter defined in text - E[, /2] complete elliptic integral of the second kind - d damping factor - F, G, H functions - l, l^*(=/v) mixing length - M_O, _O functions - r, r^*(=ru/v) radius - A real part of function - R, S, T, U functions - u, u^*(=u/u) velocity in flow direction Z - friction velocity - x, y, z co-ordinates (z in flow direction) - y^*(=yu/v) non-dimensional wall distance - fluid density - , _eff kinematic viscosity, effective kinematic viscosity - phase angle, or polar coordinate angle - shear stress - (=r/r_W) radius ratio - angular velocity Suffixes w wall value - far from a wall     

Tetrazolo[1,5‐a]quinoline‐4‐carbaldehyde and its Schiff base on mild steel as corrosion inhibitor in 1 M HCl solution: electrochemistry,theoretical and SEM surface analysis

The corrosion inhibition impact of two quinoline derivatives, viz tetrazolo [1,5‐a] quinoline‐4‐carbaldehyde ( TQC ) and (Z) ?5‐methyl‐N‐(tetrazolo [1,5‐a] quinolin‐4‐ylmethylene) thiazol‐2‐amine ( MTQT ), has been examined against mild steel in 1 M HCl solution using conventional weight loss, potentiodynamic polarization, linear polarization, electrochemical impedance spectroscopy, quantum chemical, and scanning electron microscopic studies. The experimental results have showed that TQC and MTQT revealed a good corrosion inhibition and that the inhibition efficiency increases with the increase of concentration of inhibitor to attain 94.54% for TQC and 99.25% for MTQT at 25 ppm. Polarization measurements suggest that TQC and MTQT act as a mixed‐type inhibitor. A synergism between inhibitors can be observed by polarization measurements. Electrochemical impedance spectroscopy measurements show an increase of the transfer resistance with the inhibitor concentration. Adsorption of TQC and MTQT on the mild steel surfaces in 1 N HCl solution follows the Langmuir adsorption isotherm model. Furthermore, quantum chemical calculations have been conducted using B3LYP functional and 6‐31G(d,p) basis set to complement the experimental evidences. Copyright © 2015 John Wiley & Sons, Ltd.     

Participation of C-H Protons in the Dissociation of a Proton Deficient Dipeptide

The dissociation of anionic dipeptides Phe*Gly and GlyPhe*, where Phe* refers to sulfonated phenyl alanine, has been investigated by using ion trap mass spectrometry. The dipeptides undergo collision-induced dissociation (CID) to give the same products, indicating that they rearrange to a common structure before dissociation. The rearrangement does not occur with the dipeptide methyl esters. The structures of the b₂ ions were investigated to determine the effect that having a remote, anionic site has on product formation. Comparison with the CID spectra for authentic structures shows that the b₂ ion obtained from GlyPhe* has predominantly a diketopiperazine structure. The CID spectra for the Phe*Gly b₂ ion and the authentic oxazolone are similar, but differences in intensity suggest a two-component mixture. Isotopic labeling studies are consistent with the formation of two products, with one resulting from loss of a non-mobile proton on the Gly α-carbon. The results are attributed to the formation of an oxazole and oxazolone enol product. Electronic structure calculations predict that the enol structure of the Phe*Gly b₂ ion is lower in energy than the keto version due to intramolecular hydrogen bonding with the sulfonate group.

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Graphical Abstract ?

     

Improvement of some pharmaceutical properties of mycophenolate mofetil (MMF) by para sulphonatocalix[4]resorcinarene inclusion complex

As a part of our investigations to unfold the chemistry of calixresorcinarene, we have focused on the formation of inclusion complex of a poorly soluble (43 μg ml^?1 at pH 7) drug mycophenolate mofetil (MMF) an immunosuppressive agent and an inosine monophosphate dehydrogenase (IMPDH) inhibitor with para sulphonatocalix[4]resorcinarene (PSC4R). The complete complexation of the drug was achieved after 48 h of stirring with para sulphonatocalix[4]resorcinarene(PSC[4]R) in water and evaporation of water yield the solid complex. The interaction between para sulphonatocalix[4]resorcinarene(PSC[4]R) and MMF in solid state inclusion complexes was accomplished by aqueous phase solubility studies, Thermal Analysis, HPLC, PXRD, FT-IR, and UV–Vis spectroscopy. The results of the phase solubility experiments are in good conformity to signify the formation of 2:1 PSC4R: MMF complexes. The purpose of this study was to enhance solubility and resulting in high dissolution rate and bioavailability of this essentially water insoluble drug. The results of the in vivo study shows that there is a remarkable change in the toxicity of the pure drug MMF and complex did not produce any mortality up to 2200 mg kg^?1.     

Cost of power—the user's perspective

With the advent of fiber in the loop, transmission of power ceases to be through the traditional communications medium, and the objective of powering voice lines over fiber with the same reliability goals as plain old telephone service (POTS) raises several technological, regulatory, and business issues. In order to power the optical network unit (ONU) and provide backup power for it during commercial power outages, three strategies are identified: 1) providing loop powering from a -48 volt CO/CEV power plant; 2) providing power and backup power locally, from or near the end of the loop in proximity to the OW; and 3) providing power from the curb or a power node. This paper constructs economic models to determine the worth of a watt at the 5-volt logic level at an ONU for each of the powering strategies. By normalizing all costs to the worth of a watt, comparisons can be made and appropriate architectures can be selected for various applications.     

Mechanical deformations of a liquid crystal elastomer at director angles between 0° and 90°: Deducing an empirical model encompassing anisotropic nonlinearity

Despite the wealth of studies reporting mechanical properties of liquid crystal elastomers (LCEs), no theory can currently describe their complete mechanical anisotropy and nonlinearity. Here, we present the first comprehensive study of mechanical anisotropy in an all‐acrylate LCE via tensile tests that simultaneously track liquid crystal (LC) director rotation. We then use an empirical approach to gain a deeper insight into the LCE's mechanical responses at values of strain, up to 1.5, for initial director orientations between 0° and 90°. Using a method analogous to time–temperature superposition, we create master curves for the LCE's mechanical response and use these to deduce a model that accurately predicts the load curve of the LCE for stresses applied at angles between 15° and 70° relative to the initial LC director. This LCE has been shown to exhibit auxetic behavior for deformations perpendicular to the director. Interestingly, our empirical model predicts that the LCE will further demonstrate auxetic behavior when stressed at angles between 54° and 90° to the director. Our approach could be extended to any LCE; so it represents a significant step forward toward models that would aid the further development of LCE theory and the design and modeling of LCE‐based technologies. © 2019 The Authors. Journal of Polymer Science Part B: Polymer Physics published by Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2019, 57, 1367–1377     

A simple entry into nido-C2B10 clusters: HCl promoted cleavage of the C-C bond in ortho-carboranyl diphosphines

Treatment of the diphosphines ortho-B10H10C(P(t)Bu2)C(PR2) (R = Et, Cy, Ph) with HCl gives the zwitterionic, nido-12-vertex species B10H10C(PH(t)Bu2)C(PClR2); these reactions are reversed by the addition of NEt3.