全文获取类型
收费全文 | 51137篇 |
免费 | 9931篇 |
国内免费 | 1442篇 |
专业分类
化学 | 53006篇 |
晶体学 | 410篇 |
力学 | 682篇 |
数学 | 4052篇 |
物理学 | 4360篇 |
出版年
2023年 | 107篇 |
2022年 | 145篇 |
2021年 | 669篇 |
2020年 | 1516篇 |
2019年 | 2897篇 |
2018年 | 1278篇 |
2017年 | 859篇 |
2016年 | 3791篇 |
2015年 | 3923篇 |
2014年 | 3838篇 |
2013年 | 4876篇 |
2012年 | 3767篇 |
2011年 | 3110篇 |
2010年 | 3422篇 |
2009年 | 3356篇 |
2008年 | 3169篇 |
2007年 | 2525篇 |
2006年 | 2108篇 |
2005年 | 2243篇 |
2004年 | 1965篇 |
2003年 | 1749篇 |
2002年 | 2441篇 |
2001年 | 1557篇 |
2000年 | 1477篇 |
1999年 | 532篇 |
1998年 | 212篇 |
1997年 | 194篇 |
1996年 | 225篇 |
1995年 | 181篇 |
1994年 | 189篇 |
1993年 | 191篇 |
1992年 | 152篇 |
1991年 | 139篇 |
1990年 | 119篇 |
1989年 | 120篇 |
1988年 | 108篇 |
1986年 | 112篇 |
1985年 | 126篇 |
1984年 | 133篇 |
1982年 | 119篇 |
1980年 | 122篇 |
1978年 | 113篇 |
1967年 | 108篇 |
1966年 | 190篇 |
1965年 | 155篇 |
1964年 | 166篇 |
1963年 | 150篇 |
1962年 | 141篇 |
1961年 | 155篇 |
1960年 | 147篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
A series of KF/Al2O3 catalyzed Michael-addition reactions between malononitrile and α,β-unsaturated cycloketones in DMF solution were studied. At room temperature, 2-cyano-3-aryl-3-(1,2,3,4-tetrahydronaphthalen-1-one-2-yl) propionitrile derivatives were synthesized by the reaction between 2-arylmethylidene-1,2,3,4-tetra-hydronaphthalen-1-one and malononitrile. However, if the temperature was increased to 80℃, 2-amino-3-cyano-4-aryl-4H-benzo[h]chromene derivatives were obtained in high yields. When the α,β-unsaturated ketones were replaced by 2,6-biarylmethylidenecyclohexanone or 2,5-biarylmethylidenecyclopentanone, another series of 2-amino-3-cyano-4H-pyran derivatives was isolated successfully. The structures of the products were confirmed by X-ray diffraction analysis. 相似文献
992.
Maurício Cavicchioli Antonio Carlos Massabni Luciana Rebelo Guilherme Eduardo Ernesto Castellano Armando Paduan-Filho Ana Maria da Costa Ferreira 《Transition Metal Chemistry》2007,32(3):355-361
Structural, electrochemical and spectroscopic data of a new dinuclear copper(II) complex with (±)-2-(p-methoxyphenoxy)propionic acid are reported. The complex {tetra-μ-[(±)-2-(p-methoxyphenoxy)propionato-O,O′]-bis(aqua)dicopper(II)} crystallizes in the monoclinic system, space group P21/n with a = 14.149(1) ?, b = 7.495(1) ?, c = 19.827(1) ?, β = 90.62(1) and Z = 4. X-ray diffraction data show that the two copper(II) ions are held together through four carboxylate bridges, coordinated
as equatorial ligands in square pyramidal geometry. The coordination sphere around each copper ion is completed by two water
molecules as axial ligands. Thermogravimetric data are consistent with such results. The ligand has an “L” type shape due
to the angle formed by the β-carbon of the propionic chain and the linked p-methoxyphenoxy group. This conformation contributes to the occurrence of a peculiar structure of the complex. The complex
retains its dinuclear nature when dissolved in acetonitrile, but it decomposes into the corresponding mononuclear species
if dissolved in ethanol, according to the EPR measurements. Further, cyclic voltammograms of the complex in acetonitrile show
that the dinuclear species maintains the same structure, in agreement with the EPR data in this solvent. The voltammogram
shows two irreversible reduction waves at E
pc = −0.73 and −1.04 V vs. Ag/AgCl assigned to the Cu(II)/Cu(I) and Cu(I)/Cu° redox couples, respectively, and two successive oxidation waves at E
pa =− 0.01 and +1.41 V vs. Ag/AgCl, assigned to the Cu°/Cu(I) and Cu(I)/Cu(II) redox couples, respectively, in addition to the oxidation waves of the
carboxylate ligand. 相似文献
993.
Hai‐Yang Liu Shi‐Jin Li Yi Zhao Wei Ni Xiao‐Jiang Hao Jun‐Zhu Li Yan Hua Bai‐Bo Xie Chen Qing Chang‐Xiang Chen 《Helvetica chimica acta》2007,90(10):2017-2023
Four new podocarpane‐type trinorditerpenenes, (5β,10α)‐12,13‐dihydroxypodocarpa‐8,11,13‐trien‐3‐one ( 1 ), (5β,10α)‐12‐hydroxy‐13‐methoxypodocarpa‐8,11,13‐trien‐3‐one ( 2 ), (5β,10α)‐13‐hydroxy‐12‐methoxypodocarpa‐8,11,13‐trien‐3‐one ( 3 ), and (3α,5β,10α)‐13‐methoxypodocarpa‐8,11,13‐triene‐3,12‐diol ( 4 ), together with four known diterpenes, 12‐hydroxy‐13‐methylpodocarpa‐8,11,13‐trien‐3‐one ( 5 ), spruceanol ( 6 ), ent‐3α‐hydroxypimara‐8(14),15‐dien‐12‐one ( 7 ), and ent‐3β,14α‐hydroxypimara‐7,9(11),15‐triene‐12‐one ( 8 ), were isolated from the twigs and leaves of Aleurites moluccana. Their structures were elucidated by means of comprehensive spectroscopic analyses, including NMR and MS. Except 8 , all compounds were evaluated for their cytotoxicity; compound 4 exhibited moderate inhibitory activity against Raji cells with an IC50 value of 4.24 μg/ml. 相似文献
994.
Two new ent‐abietane diterpenoids, macrophynin E ( 1 ) and macrophynin F ( 2 ), and a known related ent‐abietanoid (?)‐lambertic acid ( 3 ), together with four known ent‐kauranoids, were isolated from the roots and aerial parts of Isodon macrophylla, respectively. The structures of the new compounds were elucidated on the basis of spectroscopic‐data analysis and chemical correlations. 相似文献
995.
A new tocopherol derivative, 7a‐methoxy‐α‐tocopherol ( 1 ), and a new taraxastane triterpene, taraxast‐1,20(30)‐dien‐3‐one ( 5 ), together with four known compounds, β‐tocopherol ( 2 ), α‐tocopherol ( 3 ), α‐tocospiro B ( 4 ) and taraxasterone ( 6 ) were isolated from the whole plant of Sida acuta. Their structures were elucidated by spectral analysis including MS, 1D and 2D‐NMR spectroscopy. Among those compounds, compounds 1 , 2 , and 3 showed significant antioxidant effect (EC50 = 86.9, 68.2, and 70.9 μM, respectively) in the DPPH radicals scavenging activity assay. 相似文献
996.
This paper presents a simple, rapid and reproducible method of analysis of salbutamol in pharmaceutical products, utilizing batch injection analysis (BIA) associated with amperometric detection. A study of salbutamol oxidation demonstrated a strong dependence between electrode fouling and pH. All determinations were done utilizing a glassy carbon electrode in presence of 3.0 mol l−1 NaOH. A large linear dynamic range from 8×10−7 to 2×10−4 mol l−1 was obtained by using an injected volume of 100 μl with a detection limit of 2.5×10−7 mol l−1. R.S.D. of 0.92% for 50 successive injections of 4×10−6 mol l−1 of salbutamol and a sample throughput of 60 samples per hour were achieved. The method was applied for salbutamol quantification in syrups. 相似文献
997.
Anderson KW Mendez-Perez M Priego J Buchwald SL 《The Journal of organic chemistry》2003,68(25):9563-9573
The first detailed study of the palladium-catalyzed amination of aryl nonaflates is reported. Use of ligands 2-4 and 6 allows for the catalytic amination of electron-rich and -neutral aryl nonaflates with both primary and secondary amines. With use of Xantphos 5, the catalytic amination of a variety of functionalized aryl nonaflates resulted in excellent yields of anilines; even 2-carboxymethyl aryl nonaflate is effectively coupled with a primary alkylamine. Moderate yields were obtained when coupling halo-aryl nonaflates with a variety of amines, where in most cases the aryl nonaflate reacted in preference to the aryl halide. Overall, aryl nonaflates are an effective alternative to triflates in palladium-catalyzed C-N bond-forming processes due to their increased stability under the reaction conditions. 相似文献
998.
Novel linear poly(NIPA‐co‐CL) copolymers have been synthesized by radical copolymerization of N‐isopropylacrylamide (NIPA) and 2‐methylene‐1,3‐dioxepane (MDO). The structure of copolymers was confirmed by 1H NMR and IR spectroscopy. Cross‐linked poly(NIPA‐co‐CL) hydrogels have also been prepared in toluene using N,N′‐methylenebisacrylamide as cross‐linking agent. The hydrogels thus obtained exhibit good temperature response and are biodegradable in the presence of proteinase K.
999.
Monfrecola G Procaccini EM D'Onofrio D Roberti G Liuzzi R Staibano S Manco A De Rosa G Santoianni P 《Journal of photochemistry and photobiology. B, Biology》2002,68(2-3):147-155
Photodynamic therapy (PDT) with 5-aminolaevulinic acid (ALA) is an alternative tool for the treatment of superficial non-melanoma skin cancers. Recently ALA-PDT has been employed with encouraging results also for warts, condylomata and psoriasis. In this study the effects of topical ALA plus irradiation with visible light on intact human skin have been evaluated. Five skin areas (A, B, C, D, and E) on the inner upper part of the arms of five healthy volunteers (skin types III and IV) were treated with (A) ALA 20% in base cream without irradiation, (B) only the vehicle (base cream) without ALA, (C, D and E) ALA cream at the concentrations of 5, 10 and 20%, respectively; all treatments were applied with an occlusive dressing. Four hours after ALA or vehicle application areas B, C, D and E were irradiated with a fixed dose of 40 J/cm(2). ALA penetration through the intact skin was evaluated by in vivo fluorescence determination. The effects on healthy skin were evaluated by clinical and chromometric examinations, light microscopy, immunohistochemistry and electron microscopy. RESULTS: (1) in vivo fluorescence demonstrated that ALA is able to penetrate through the intact skin, when applied with occlusive dressing and induces a classical fluorescence peak due to Protoporphyrin IX (PpIX) formation, which is the active photosensitiser. (2) Skin areas receiving ALA plus irradiation showed erythema and swelling just after the irradiative session and hyperpigmentation 48-72 h later. (3) Colourimetric data confirmed significant skin colour changes: values a* (representing the erythematous changes) increased only on the skin areas where ALA+irradiation were applied and during the 48 h after irradiation, thereafter a* began to decrease; values L* (pigmentation) increased during the 2 weeks following treatment. (4) Histopathological, immunohistochemical (S100, HMB-45) and electron microscopic findings showed an absolute increment of the number of melanocytes, which appeared clearly activated. In conclusion the application of ALA cream followed by irradiation is able to induce a pigmentation response in healthy human skin, at least in skin types III and IV. This melanocytic activation could have a potential for the treatment of skin disorders characterised by hypopigmentation. 相似文献
1000.
Bigoli F Deplano P Mercuri ML Pellinghelli MA Pilia L Pintus G Serpe A Trogu EF 《Inorganic chemistry》2002,41(20):5241-5248
New [M(R(2)pipdt)(2)](BF(4))(2) salts [R(2)pipdt = N,N'-dialkyl-piperazine-2,3-dithione; M = Pd(II), R = Me and M = Pt(II), R = Me, Et, Pr(i)] bearing redox-active cationic dithiolene complexes have been prepared and characterized. These cations react with the redox-active [M(mnt)(2)](2-) [M = Pd(II), Pt(II); mnt = maleonitrile-2,3-dithiolate] anionic dithiolenes to form salts describable as ion pair charge-transfer complexes. X-ray crystallographic studies have shown that [M(Me(2)pipdt)(2)][M(mnt)(2)] complexes, with M = Pd(II) and Pt(II), are isomorphous. Crystal data of the Pt salt (3a): triclinic, Ponemacr; (No. 2); Z = 1; T = 293(2) K; a = 6.784(7) A, b = 8.460(6) A, c = 13.510(5) A, alpha = 100.63(2) degrees, beta = 104.04(2) degrees, gamma = 96.90(2) degrees; R1 = 0.0691 [wR2 = 0.2187 (all data)]. Structural data show that approximately square-planar [Pt(Me(2)pipdt)(2)] dications and regular square-planar [Pt(mnt)(2)] dianions form an infinite anion-cation one-dimensional stack along axis a with a Pt...Pt a/2 distance of 3.392 A and a Pt...Pt...Pt angle of 180 degrees. Anions and cations arrange themselves face-to-face so as to take on a staggered arrangement. These salts exhibit strong absorptions in the visible-near-infrared region assigned to ion pair charge-transfer transitions. A relation between the optical and thermal electron transfer in the solid state is obtained using a "Marcus-Hush model", and a solid-state electrical conductivity in agreement with expectations is observed. Vibrational spectroscopy is in agreement with the existence of charge-transfer interactions between the cationic and anionic components of the salts. 相似文献