Novel Petasis boronic acid-Mannich reactions with tertiary aromatic amines

Tertiary aromatic amines can serve as amine substrates for the Petasis boronic acid-Mannich reaction, providing a practical synthetic route for the CC bond formation of α-(4-N,N-dialkylamino-2-alkyloxyphenyl)carboxylic acids. The scope and limitations of this method have been examined.     

Metal‐Modified Nucleic Acids: Metal‐Mediated Base Pairs,Triples, and Tetrads

The incorporation of metal ions into nucleic acids by means of metal‐mediated base pairs represents a promising and prominent strategy for the site‐specific decoration of these self‐assembling supramolecules with metal‐based functionality. Over the past 20 years, numerous nucleoside surrogates have been introduced in this respect, broadening the metal scope by providing perfectly tailored metal‐binding sites. More recently, artificial nucleosides derived from natural purine or pyrimidine bases have moved into the focus of Ag^I‐mediated base pairing, due to their expected compatibility with regular Watson–Crick base pairs. This minireview summarizes these advances in metal‐mediated base pairing but also includes further recent progress in the field. Moreover, it addresses other aspects of metal‐modified nucleic acids, highlighting an expansion of the concept to metal‐mediated base triples (in triple helices and three‐way junctions) and metal‐mediated base tetrads (in quadruplexes). For all types of metal‐modified nucleic acids, proposed or accomplished applications are briefly mentioned, too.     

Basic alumina supported one-pot synthesis of structurally diverse pyridine/quinolinine-fused novel diazepanium, diazocanium, imidazodilinium and tetrahydro-pyrimidiniums

Basic alumina supported solvent-free one-pot synthesis of pyridine-fused polycyclic diazepaniums was achieved under microwave irradiation. The process was successfully extended to the synthesis of pyridine-fused bicyclic imidazolidiniums and tetrahydro-pyrimidiniums and also of tri- and tetracyclic diaza-heterocycle-fused quinoliniums. The dual characteristic of basic alumina, a solid support as well as a base, was successfully employed in the current investigation. The method emerged to be an effective route in terms of product yield, reaction time, and ease of purification and most importantly for environment friendly protocols.     

Synthesis,characterization, electrochemical and theoretical study of substituted phenyl-terpyridine and pyridine-quinoline based mixed chelate ruthenium complexes

In the present work, we report two methoxy-substituted phenyl-terpyridine ruthenium complexes with pyridine carboxyquinoline and NCS as ancillary ligands, [Ru(OMePhtpy)(pcqH)(NCS)](PF₆) (1) and [Ru(triOMePhtpy)(pcqH)(NCS)](PF₆) (2) (where OMePhtpy = (4′-(4-methoxy)phenyl-2,2′:6′,2″-terpyridine, triOMePhtpy = (4′-(3,4,5-trimethoxy)phenyl-2,2′:6′,2″-terpyridine and pcqH = pyridine-carboxyquinoline). Both complexes have been characterized by spectroscopic techniques e.g., mass, ¹H-NMR and FTIR. UV–vis spectrophotometric and electrochemical studies for both complexes have been performed. The substitution pattern of the –OMe groups have been successfully utilized to tune the redox potential of the metal complexes. On the anodic side of cyclic voltammogram, 1 and 2 show an irreversible wave corresponding to Ru^II/III couple at 0.95 and 0.85 V, respectively. The lower Ru^II/III oxidation potential for 2 may be attributed to increased electron density on ruthenium due to three (+R) methoxy–groups appended to the phenyl moiety of triOMePhtpy. DFT optimization of structure and energy calculation reveals that in both complexes, HOMO is metal- and thiocyanate-based, whereas the LUMO is based on pcqH. Correlation of TDDFT results with experimental electronic spectrum indicates that bands at 502 nm (1) and 528 nm (2) are of MLLCT character from ruthenium-thiocyanate to pcqH.     

Montmorillonite K-10 clay catalyzed solvent-free synthesis of bis-indolylindane-1,3-dione, 2-(1′,3′-dihydro-1H-[2,3′]biindolyl-2′-ylidene)-indan-1,3-dione and bisindolylindeno[1,2-b]quinoxaline under microwave irradiation

An environmentally benign protocol has been described for the synthesis of novel 2-(1′,3′-dihydro-1H-[2,3′]biindolyl-2′-ylidene)-indan-1,3-diones/bis-indolylindane-1,3-diones from ninhydrin and 3-substituted/unsubstituted indoles. It uses montmorillonite K-10 as catalyst in a solvent-free condition under microwave irradiation. The method was also used for the synthesis of novel bisindolylindeno[1,2-b]quinoxaline derivatives.     

Syntheses,characterization, X-ray crystal structures and emission properties of copper(II), zinc(II) and cadmium(II) complexes of pyridyl–pyrazole derived Schiff base ligand – Metal selective ligand binding modes

The varying coordination modes of the title ligand, L [5-methyl-1-(pyridin-2-yl)-N′-[pyridin-2-ylmethylidene]pyrazole-3-carbohydrazide] towards the different metal centers is reported by preparation and characterization of Cu(II), Zn(II) and Cd(II) complexes, [Cu(L)NO₃.H₂O](NO₃) (1) [Zn(L)₂](ClO₄)₂·2DMF (2) and [Cd(L)(I)₂] (3) respectively. In 1, the neutral ligand serves as tetradentate 4 N donor where both pyridine and pyrazole nitrogen atoms of pyridyl–pyrazole part are coordinatively active, leaving the carbonyl oxygen of the carbohydrazide part inactive. The same pyridine and pyrazole N atoms remain abstained from the coordination process towards the Zn(II) and Cd(II) metal centers. For 2 and 3 the ligand behaves as a tridentate NNO donor where the two nitrogen atoms come from azomethine, pyridine of pyridine-2-carbaldehyde parts and O from carbonyl oxygen atoms (carbohydrazide part). The complex 1 and 2 are distorted octahedral while complex 3 adopts distorted square pyramidal geometry. All the complexes are X-ray crystallographically characterized.     

Synthesis,Crystal Structure and Spectroscopic Properties of an Oximato Bridged Cu(II) Dimer

Abstract  

Schiff-base condensation of a equimolar proportion of diacetyl-monoxime monohydrazone and 1-methylimidazole-2-carboxaldehyde in methanol gives rise to the imidazole azine, 3-(1-methylimidazol-2-yl)methylenehydrazonobutan-2-one oxime(HL). Reaction of 1:1 stoichiometric proportion of HL with copper(II)perchlorate hexahydrate in methanol yields a dimeric oximato bridged copper compound, [Cu₂L₂(H₂O)₂](ClO₄)₂ (1). The compound is characterized by C, H and N analyses, FT-IR, ESI–MS, conductivity measurement, UV–Vis spectra and X-ray single crystal diffraction. The title compound (1) crystallizes in the monoclinic space group P2₁/c with a = 6.8533 (8), b = 18.413 (2), c = 11.7399 (14) ?, β = 93.685 (2)°, V = 1478.4 (3) ?³ and Z = 2. The geometry around each copper center is distorted square pyramidal. The copper(II) dimer shows antiferromagnetic interaction mediated by symmetric disposition of oximato groups.     

Synthesis of polycyclic fused 2-quinolones in aqueous micellar system

A high yielding green protocol has been developed for the synthesis of tri-, tetra-, and pentacyclic fused 2-quinolones in micellar medium. The method is more effective compared to phase-transfer catalytic (PTC) method in terms of the yield of the product as well as the reaction time. It is operationally simple as well as environmentally benign.     

Exploring the effect of radiation crosslinking on the physico‐mechanical,dynamic mechanical and dielectric properties of EOC–PDMS blends for cable insulation applications

This work focuses on the effect of electron beam irradiation on the physico‐mechanical, dynamic mechanical and dielectric properties of blends based on ethylene octene copolymer (EOC) and poly dimethyl siloxane (PDMS) rubber. It is found that electron beam irradiation caused considerable improvement in the physico‐mechanical properties; the tensile strength was enhanced by nearly 35% for 70:30 EOC:PDMS blend. Phase morphology of the blends analyzed before irradiation by scanning electron microscopy (SEM) exhibited droplet/matrix morphology with sizes of the PDMS rubber domain varying from 0.55 µm to 0.47 µm as the amount of PDMS rubber decreased from 30 wt% to 10 wt%. This reduction in the PDMS rubber domain has been correlated with the physico‐mechanical properties of the blends. Further, the dynamic mechanical properties and creep behavior of these EOC:PDMS blends before and after irradiation has been studied. It is inferred that the 70:30 blend after radiation crosslinking shows a 17% decrease in the creep compliance, i.e. higher creep resistance compared to neat blends. All the radiation crosslinked blends exhibited lower dielectric constant, lower dielectric loss and higher electrical resistivity as compared to the virgin blends which makes it suitable for cable insulating application. Copyright © 2016 John Wiley & Sons, Ltd.     

Synthesis, crystal structure determination, spectroscopic and electrochemical studies of trans-[Ru(PPh3)2(bbpH2)Cl]Cl·CHCl3·H20 (bbpH2=2,6-bis(benzimidazolyl) pyridine) – an infinite double columnar supramolecule in the solid state

The synthesis, crystal structure, redox and spectroscopic properties of trans-[Ru(bbpH₂)(PPh₃)₂Cl]Cl are reported. In the crystalline solvate trans-[Ru(bbpH₂)(PPh₃)₂cCl]Cl CHCl₃ H₂O, the molecular components are connected by strong intermolecular hydrogen bonding to form an infinite double column.