An Iron(III)-Monoamidate Complex Catalyst for Selective Hydroxylation of Alkane CH Bonds with Hydrogen Peroxide

Selective oxidation: The success of the title reaction is caused by the strong electron donation from the amidate moiety of the dpaq ligand to the iron center (dpaq=2-[bis(pyridin-2-ylmethyl)]amino-N-quinolin-8-yl-acetamidate). This process facilitates the O?O bond heterolysis of the intermediate Fe(III) OOH species to generate a selective oxidant without forming highly reactive hydroxyl radicals.     

Magnetic resonance differentiation between T2 and T1 gallbladder carcinoma: significance of subserosal enhancement on the delayed phase dynamic study

Purpose

The aim of this study is to investigate whether subserosal enhancement on the delayed-phase dynamic magnetic resonance (MR) study (SED) can differentiate T2 from T1 gallbladder carcinoma (GBC).

Methods

The institutional research board approved this retrospective study. Between 1997 and 2006, there were surgically proven 11 T1 and 21 T2 GBC in 30 patients, all of whom had undergone preoperative contrast enhanced dynamic MR study, either with a 2D sequence (n=17) or 3D sequences (n=15). All images were reviewed by two radiologists for the presence of SED, and receiver operating characteristic (ROC) curve analysis was performed. Sensitivity, specificity, positive and negative predictive values were calculated by consensus.

Results

The areas under the ROC curves of the two readers were 0.91 and 0.86, and the kappa value was 0.78. Of the 21 T2 GBC, 18 and 3 showed positive and negative SED, respectively. Of the 11 T1 GBC, 1 and 10 showed positive and negative SED, respectively. The sensitivity, specificity, positive and negative predictive values of SED for diagnosing T2 lesions were 86%, 88%, 91% and 77%, respectively.

Conclusions

In conclusion, SED may be a useful sign to differentiate T2 from T1 GBC, which would affect the preoperative surgical planning of the patients.     

A finite type invariant of order at most 4 for genus 2 handlebody-knots is a constant map

We show that a finite type invariant of order at most 4 for genus 2 handlebody-knots is a constant map. For this purpose, we give a concrete basis for the vector space of all finite type invariants of order at most 4 for spatial theta-curves, which makes a correction to Koike?s result. Each invariant of the basis is derived from the HOMFLYPT polynomial of the associated 3-component link of a spatial theta-curve.     

Selective Capture and Collection of Live Target Cells Using a Photoreactive Silicon Wafer Device Modified with Antibodies via a Photocleavable Linker

A device for the capture and recollection of live target cells is described. The platform was a silicon (Si) wafer modified with an anti-HEL antibody (anti-HEL-IgG, HEL = hen egg lysozyme) through a photocleavable 3-amino-3-(2-nitrophenyl)propionic acid (ANP) linker. The modification processes of the Si wafer surface were monitored by Fourier transform infrared spectroscopy-attenuated total reflection (FTIR-ATR) and fast-scanning atomic force microscopy (FS-AFM). The attachment of IgG and its release reaction on the Si surface via the photochemical cleavage of the ANP linker were observed directly by FS-AFM. The results of an enzyme-linked immunosorbent assay (ELISA) indicated that the photorelease of the complex of anti-HEL-IgG with the secondary antibody-alkaline phosphatase hybrid (secondary IgG-AP) from the Si surface occurs with minimum damage. Furthermore, it was possible to collect SP2/O cells selectively that express HEL on their cell membranes (SP2/O-HEL) on the Si wafer device. Photochemical cleavage of the ANP linker facilitated the effective release of living SP2/O cells whose viability was verified by staining experiments using tripan blue. Moreover, it was possible to reculture the recovered cells. This methodology represents an effective strategy for isolating intact target cells in the biological and medicinal sciences and related fields.     

ZIF-8 immobilized nickel nanoparticles: highly effective catalysts for hydrogen generation from hydrolysis of ammonia borane

Highly dispersed Ni nanoparticles have been successfully immobilized by the zeolitic metal-organic framework ZIF-8 via sequential deposition-reduction methods, which show high catalytic activity and long durability for hydrogen generation from hydrolysis of aqueous ammonia borane (NH(3)BH(3)) at room temperature.     

A Chemo-Enzymatic Expeditious Route to Racemic Dihexanoyl (2R*,3R*,4R*)-Dehydroxymethylepoxyquinomycin (DHMEQ), the Precursor for Lipase-Catalyzed Synthesis of the Potent Nuclear Factor-κB Inhibitor, (2S,3S,4S)-DHMEQ

In order to synthesize the potent nuclear factor (NF)-κB inhibitor, (2S,3S,4S)-dehydroxymethylepoxyquinomycin (DHMEQ), in a large scale, a new route for its corresponding racemic precursor, dihexanoyl (2R*,3R*,4R*)-DHMEQ, was developed. By employing both hydroquinone and benzoquinone intermediates, the total yield, reproducibility, and synthetic steps were improved and the synthetic cost was reduced.     

Almost Alternating Diagrams and Fibered Links in S3

Let R be a Seifert surface obtained by applying Seifert's algorithmto a connected diagram D for a link L. In this paper, lettingD be almost alternating, we give a practical algorithm to determinewhether L is a fibered link and R is a fiber surface. We furthershow that L is a fibered link and R is a fiber surface for Lif and only if R is a Hopf plumbing, that is, a successive plumbingof a finite number of Hopf bands. It has been known for sometime that this is true if D is alternating, and we show thatit is not always true if D is 2-almost alternating. In the appendix,we partially answer C. Adams's open question concerning almostalternating diagrams. 2000 Mathematical Subject Classification:57M25.     

Crosscap numbers of 2-bridge knots

We present a practical algorithm to determine the minimal genus of non-orientable spanning surfaces for 2-bridge knots, called the crosscap numbers. We will exhibit a table of crosscap numbers of 2-bridge knots up to 12 crossings (all 362 of them).