A new class of isoquinoline alkaloids: The indenobenzazepines

The dark yellow indenobenzazepine alkaloids lahorine ($\text{1}$) and lahoramine ($\text{2}$) have been found in $\text{Fumaria}$$\text{parviflora}$ Lam. (Fumariaceae). In a transformation with biogenetic implications, treatment of the spirobenzylisoquinolines dihydrofumariline ($\text{4}$) and dihydroparfumidine ($\text{7}$) with methanesulfonyl chloride and triethylamine in dry THF, followed by iodine oxidation, provided $\text{1}$ and $\text{2}$, respectively.     

CSE-MECC two-dimensional capillary electrophoresis analysis of proteins in the mouse tumor cell (AtT-20) homogenate

Two-dimensional capillary electrophoresis was used for the separation of proteins and biogenic amines from the mouse AtT-20 cell line. The first-dimension capillary contained a TRIS–CHES–SDS–dextran buffer to perform capillary sieving electrophoresis, which is based on molecular weight of proteins. The second-dimension capillary contained a TRIS–CHES–SDS buffer for micellar electrokinetic capillary chromatography. After a 61-s preliminary separation, fractions from the first-dimension capillary were successively transferred to the second-dimension capillary, where they further separated by MECC. The two-dimensional separation required 60 min.     

Hypercomplex analysis and integration of systems of ordinary differential equations

We review the theory of hypercomplex numbers and hypercomplex analysis with the ultimate goal of applying them to issues related to the integration of systems of ordinary differential equations (ODEs). We introduce the notion of hypercomplexification, which allows the lifting of some results known for scalar ODEs to systems of ODEs. In particular, we provide another approach to the construction of superposition laws for some Riccati‐type systems, we obtain invariants of Abel‐type systems, we derive integrable Ermakov systems through hypercomplexification, we address the problem of linearization by hypercomplexification, and we provide a solution to the inverse problem of the calculus of variations for some systems of ODEs. Copyright © 2016 John Wiley & Sons, Ltd.     

Parviflorine,a glycosidic spirobenzylisoquinoline alkaloid

(+)-Parviflorine ($\text{1}$), found in $\text{Fumaria parviflora}$ Lam. (Fumariaceae), is the first known glycosidic spirobenzylisoquinoline alkaloid. Its acid hydrolysis yields (+)-parfumine ($\text{4}$) and D-glucose. Klyne's rule indicates that $\text{1}$ is a β-D-glucoside. The absolute configuration shown in expressions $\text{1-11}$ is predominant among spirobenzylisoquinolines. A generalization has been drawn between plant source and the oxygenation pattern of ring C for the spirobenzylisoquinoline alkaloids.     

Low temperature magnetic properties of Cr0.25Co0.25Zn0.5Fe2O4 nano particles

Low temperature Mössbauer and AC susceptibility have been used to study relaxation phenomena in nano-sized particles of Cr_0.25Co_0.25Zn_0.5Fe₂O₄. From these studies, the energy density constant for this system has been estimated to be 4 x 10⁶ erg/cm³. Cation distribution has also been determined and the observed results are correlated to calculated relaxation times.     

A review on <Superscript>90</Superscript>Y-labeled compounds and biomolecules

The field of therapeutic nuclear medicine is emerging rapidly as choice of treatment in oncology and other cellular malignancies. The growth of this branch of nuclear medicine is greatly facilitated by the introduction of a number of new radiopharmaceuticals and radionuclides. ⁹⁰Y-radiopharmaceuticals have confirmed their worth in medical and clinical areas in a very short span of time. The ⁹⁰Y is a radioisotope widely used for therapeutic purposes and considerable perfection has been made to understand the chemistry of ⁹⁰Y-labeled radiopharmaceuticals. The development of these radiopharmaceuticals can be made favorable by using appropriate buffer, incubation period, optimal pH, specific activity and reaction temperature. In this review, we have discussed the preparation of range of ⁹⁰Y transporting biological molecules such as antibodies radiolabeled peptides, antigens and microsphere with their clinical applications.     

Mixed-ligand complexes of copper(I) with diimines and phosphines: Effective catalysts for the coupling of phenylacetylene with halobenzene

New copper(I) mixed-ligand complexes 1–4 of the formula Cu(N–N)PR₃X, where N–N = 1,10-phenanthroline (phen), 2,2′-bipyridine (bpy), 5,5′-dimethyl-2,2′-bipyridine (5,5′dimbpy) and PR₃ = tricyclohexylphosphine, tris(2-cyanoethyl)phosphine and isopropyldiphenylphosphine, have been synthesized. The complexes were characterized by EA, IR, NMR and single crystal X-ray diffraction. The solution fluorescence emission spectra were measured. The single crystal X-ray analysis showed that the copper(I) ion is four-coordinate with a distorted tetrahedral geometry. The complexes catalyze the formation of diphenylacetylene from the coupling of halobenzene with phenylacetylene. The complex Cu(5,5′-dimethylbpy)P{(cyhexyl)₃}I showed the highest catalytic activity. At room temperature all four complexes exhibit, in dichloromethane, emission maxima in the 329–344 nm range, corresponding to intra-ligand excited states.     

Photodamage and Photoprotection: An In vivo Approach Using Noninvasive Probes

Solar radiations trigger the physiological alteration in skin which progress toward photoaging. Sunscreens are known to be effective against the photodamaging effects of sunlight. The purpose of this study was to evaluate the extent to which aging signs caused by real‐life sunlight exposure could be avoided by comparing various parameters between sun‐exposed and sun‐protected skin using noninvasive probes. Female volunteers (n = 11) after getting their consent were provided with marketed sunscreen product to apply onto their skin for 6 months. Measurements were scheduled every 15 days from the baseline reading for 6 months. Cutometer, Mexameter and Corneometer were used for evaluation of facial skin parameters. Clinical evaluations showed the effects of sunlight exposure on different skin parameters by comparing sun‐protected and unprotected skin, where Gross elasticity (R2), Net elasticity (R5), Viscoelasticity (R6) and Biological elasticity (R7) showed insignificant results, while Hydration, Melanin and Erythema showed significant results. Sun‐exposed skin presented 0.72%, 0.66%, 0.77%, 1.39%, 1.99%, 2.01% and 3.15% changes in R2, R5, R6 and R7, melanin, erythema and hydration, respectively, which were potentially prevented by sunscreen application. Premature aging is inhibited by following photoprotective regimen on routine basis, emphasizing the potential benefit of sunscreen against early aging signs.