Humulene derivatives from Zingiber zerumbet with the inhibitory effects on lipopolysaccharide-induced nitric oxide production

A new humulene sesquiterpene, 5-hydroxyzerumbone (5-hydroxy-2E,6E,9E-humulatrien-8-one) (1) and a known compound, zerumboneoxide (2) were isolated from the rhizomes of Zingiber zerumbet (Zingiberaceae), and found to inhibit lipopolysaccharide-induced nitric oxide production in murine macrophage RAW 264.7 cells with IC50 values of 14.1 and 23.5 microM, respectively, by bioassay-guided fractionation (positive control: N(omega)-monomethyl-L-arginine, IC50=21.3 microM). The structure of 1 was determined by spectroscopic methods including 1D and 2D-NMR.     

New cytotoxic cucurbitacins from the pericarps of Trichosanthes tricuspidata fruits

An extract of the fruits of Trichosanthes tricuspidata collected in North Vietnam was found cytotoxic in KB cells. A bioassay-guided fractionation led to the isolation of a series of cucurbitacins of which two are new: tricuspidatin and 2-O-glucocucurbitacin J. Their isolation and structure determination are described.     

Total synthesis of (±)-monomorine

An efficient, two-operation synthesis of the trail ant pheromone (±)-monomorine is reported. The synthesis features an aqueous Claisen-Schmidt condensation followed by the stereocontrolled installation of the three resident stereocenters in a single operation.     

A new benzofuran derivative from the leaves of Ficus pumila L.

A new benzofuran derivative, pumiloside (1), together with seven known flavonoid glycosides, afzelin (2), astragalin (3), quercitrin (4), isoquercitrin (5), kaempferol 3-O-rutinoside (6), rutin (7) and kaempferol 3-O-sophoroside (8) were isolated from the leaves of Ficus pumila. Their structures were established by spectroscopic data and comparison with the literature values.     

Some Properties of Local Cohomology Modules Defined by a Pair of Ideals

Mathematical Notes - Let $$R$$ be a commutative Noetherian ring with identity and $$I,J$$ two ideals of $$R.$$ We introduce the concept of $$(I,J)$$ -coweakly Laskerian module and study the...     

The Ramsey number of paths with respect to wheels

For graphs G and H, the Ramsey numberR(G,H) is the smallest positive integer n such that every graph F of order n contains G or the complement of F contains H. For the path P_n and the wheel W_m, it is proved that R(P_n,W_m)=2n-1 if m is even, m?4, and n?(m/2)(m-2), and R(P_n,W_m)=3n-2 if m is odd, m?5, and n?(m-1/2)(m-3).     

Synthesis of Some Novel Norbornene‐Fused Pyridazines as Potent Inhibitors of Carbonic Anhydrase and Acetylcholinesterase

The reaction of benzocyclic norbornene derivatives with tetrazines provided the 1,3‐dihydropyridazine derivatives as a single product. The dihydropyridazine derivatives have been dehydrogenated with phenyliodine bis(trifluoroacetate) to yield the corresponding pyridazines in a high yield. Two stable diazines, primary product of corresponding 1,4‐dihydropyridazine, were also isolated. Structures were then determined by ¹H‐NMR, and ¹³C‐NMR beside to elemental analyses. The novel pyridazine derivatives ( 8 , 9 ) efficiently inhibited the cytosolic human carbonic anhydrase isoenzymes I and II (hCA I and II). In addition, these novel pyridazine derivatives ( 8 , 9 ) were evaluated for their in vitro acetylcholinesterase inhibitory activity. Ligand–receptor interactions are tested using molecular docking simulations. Obtained docking scores are in good agreement with in vitro results.     

One-loop formulas for H → Zνlνl for l = e, μ, τ in 't Hooft-Veltman gauge

In this paper, we present analytical results for one-loop contributions to the decay processes \begin{document}$ H\rightarrow Z \nu_l\bar{\nu}_l $\end{document} (for \begin{document}$ l = e, \mu, \tau $\end{document}). The calculations are performed within the Standard Model framework in the 't Hooft-Veltman gauge. One-loop form factors are then written in terms of scalar one-loop functions in the standard notations of \begin{document}$ {\tt LoopTools}$\end{document}. As a result, one-loop decay rates for the decay channels can be evaluated numerically by using the package. Furthermore, we analyze the signals of \begin{document}$ H\rightarrow Z \nu_l\bar{\nu}_l $\end{document} via the production processes \begin{document}$ e^-e^+ \rightarrow ZH^* \rightarrow Z (H^* \rightarrow Z \nu_l\bar{\nu}_l) $\end{document}, including the initial beam polarizations at future lepton colliders. The Standard Model backgrounds, such as the processes \begin{document}$ e^-e^+ \rightarrow \nu_l\bar{\nu}_l ZZ $\end{document}, are also examined in this study. Numerical results indicate that one-loop corrections make contributions of approximately 10% to the decay rates. These are sizeable contributions and should be taken into account at future colliders. We show that the signals \begin{document}$ H\rightarrow Z\nu_l\bar{\nu}_l $\end{document} are clearly visible at the center-of-mass energy \begin{document}$ \sqrt{s}=250 $\end{document} GeV and are difficult to probe in higher-energy regions owing to the dominant backgrounds.     

A reduced mechanism for primary reactions of coal volatiles in a plug flow reactor

In the present paper, the authors study the primary reactions of coal volatiles and a detailed mechanism has been made for three different environments: thermal decomposition (pyrolysis), partial oxidation (O₂) and O₂/CO₂ gasification in a plug flow reactor to analyze the combustion component. The computed results have similar trend for three different environments with the experimental data. A systematically reduced mechanism for O₂/CO₂ gasification has also been derived by examination of Rate of Production (ROP) analysis from the detailed mechanism (255 species and 1095 reactions). The reduced mechanism shows similar result and has been validated by comparing the calculated concentrations of H₂, CH₄, H₂O, CO, CO₂ and polycyclic aromatic hydrocarbon (PAH) with those of the detailed mechanism in a wide range of operating conditions. The authors also predicted the concentration profiles of H₂, CO, CO₂ and PAH at high temperature and high pressure.